Guest guest Posted January 6, 2003 Report Share Posted January 6, 2003 I previously stated that I find it a bit lame to suggest that reduced blood flow in the CNS as a consequence of is a cause of autism but I may need to eat my words: J Radiol 2002;83(121):1829-1833 [Temporal lobe dysfonction in childhood autism: a PET study] [Article in French] Boddaert N, Chabane N, Barthelemy C, Bourgeois M, Poline J, Brunelle F, Samson Y, Zilbovicius M. Service Hospitalier Frederic Joliot, ER-M INSERM 0205, DSV, DRM, CEA, Orsay, 4, place du General Leclerc 91406, Orsay, France. PURPOSE: Childhood autism is a severe developmental disorder that impairs the acquisition of some of the most important skills in human life. Progress in understanding the neural basis of childhood autism requires clear and reliable data indicating specific neuroanatomical or neurophysiological abnormalities. The purpose of the present study was to research localized brain dysfunction in autistic children using functional brain imaging. PATIENTS AND METHODS: Regional cerebral blood flow (rCBF) was measured with positron emission tomography (PET) in 21 primary autistic children and 10 age-matched non autistic children. RESULTS: A statistical parametric analysis of rCBF images revealed significant bilateral temporal hypoperfusion in the associative auditory cortex (superior temporal gyrus) and in the multimodal cortex (superior temporal sulcus) in the autistic group (p<0.001). In addition, temporal hypoperfusion was detected individually in 77% of autistic children. CONCLUSION: These findings provide robust evidence of well localized functional abnormalities in autistic children located in the superior temporal lobe. Such localized abnormalities were not detected with the low resolution PET camera,. This study suggests that high resolution PET camera combined with statistical parametric mapping is useful to understand developmental disorders. PMID: 12511838 [PubMed - as supplied by publisher] I do still think there is a bit more to it than just that but I am prepared to be wrong. Jon. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2003 Report Share Posted January 7, 2003 Similar findings with NeuroSpects. Weight for I previously stated that I find it a bit lame to suggest that reduced blood flow in the CNS as a consequence of is a cause of autism but I may need to eat my words: J Radiol 2002;83(121):1829-1833 [Temporal lobe dysfonction in childhood autism: a PET study] [Article in French] Boddaert N, Chabane N, Barthelemy C, Bourgeois M, Poline J, Brunelle F, Samson Y, Zilbovicius M. Service Hospitalier Frederic Joliot, ER-M INSERM 0205, DSV, DRM, CEA, Orsay, 4, place du General Leclerc 91406, Orsay, France. PURPOSE: Childhood autism is a severe developmental disorder that impairs the acquisition of some of the most important skills in human life. Progress in understanding the neural basis of childhood autism requires clear and reliable data indicating specific neuroanatomical or neurophysiological abnormalities. The purpose of the present study was to research localized brain dysfunction in autistic children using functional brain imaging. PATIENTS AND METHODS: Regional cerebral blood flow (rCBF) was measured with positron emission tomography (PET) in 21 primary autistic children and 10 age-matched non autistic children. RESULTS: A statistical parametric analysis of rCBF images revealed significant bilateral temporal hypoperfusion in the associative auditory cortex (superior temporal gyrus) and in the multimodal cortex (superior temporal sulcus) in the autistic group (p<0.001). In addition, temporal hypoperfusion was detected individually in 77% of autistic children. CONCLUSION: These findings provide robust evidence of well localized functional abnormalities in autistic children located in the superior temporal lobe. Such localized abnormalities were not detected with the low resolution PET camera,. This study suggests that high resolution PET camera combined with statistical parametric mapping is useful to understand developmental disorders. PMID: 12511838 [PubMed - as supplied by publisher] I do still think there is a bit more to it than just that but I am prepared to be wrong. Jon. Quote Link to comment Share on other sites More sharing options...
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