Guest guest Posted December 24, 2006 Report Share Posted December 24, 2006 If you are in america or canada you can order DMSO from jeffersequine.com that some of here use. They are inexpensive too. They sell a 90% gel, a 99% roll on, and 99% by the pint or larger. Some may find the roll on to be drying and too strong for some skin but i use it directly on some areas, like legs and feet for arthritis. If you are mixing DMSO into EIS/CS, then you want the liquid DMSO, not MSM which if you mix into CS it will dissolve but won't have the same ability to go through the skin. I have 50% CS and 50% DMSO in small spray bottles for topical use. These spray bottles I use for cuts, burns and the like. It handled some nasty dog bites quickly, after a small but bloody fight with a big frienly lab. Ross DMSO I read a lot about mixing dmso into cs am interested give it a try fortopical use - arthritis and skin problems. If I cant get dsmo can Iuse MSM powder out of the capsules? Will appreciate any help here No virus found in this incoming message.Checked by AVG Free Edition.Version: 7.5.432 / Virus Database: 268.15.26/598 - Release Date: 12/22/2006 3:22 PM Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 14, 2007 Report Share Posted October 14, 2007 Dimethyl sulfoxide IUPAC name Dimethyl sulfoxide Other names Methyl sulfoxide methylsulfinylmethane DMSO Identifiers CAS number 67-68-5 RTECS number PV6210000 SMILES CS©=O Properties Molecular formula C2H6OS Molar mass 78.13 g/mol Appearance Clear, colorless liquid Density 1.1004 g/cm3, liquid Melting point 18.5 ‹C (292 K) Boiling point 189 ‹C (462 K) Solubility in water Miscible Acidity (pKa) 35 Refractive index (nD) 1.479 ƒÃr = 48 Viscosity 1.996 cP at 20 ‹C Structure Dipole moment 3.96 D Hazards MSDS External MSDS MSDS DMSO Material Safety Data Sheet Main hazards Irritant (Xi) NFPA 704 110 R-phrases R36/37/38 S-phrases S26, S37/39 Flash point 95 ‹C Related Compounds Related sulfoxides diethyl sulfoxide Related compounds sodium methylsulfinylmethylide, dimethyl sulfide, dimethyl sulfone, acetone Supplementary data page Structure and properties n, ƒÃr, etc. Thermodynamic data Phase behaviour Solid, liquid, gas Spectral data UV, IR, NMR, MS Except where noted otherwise, data are given for materials in their standard state (at 25 ‹C, 100 kPa) Infobox disclaimer and references Dimethyl sulfoxide (DMSO) is the chemical compound with the formula (CH3)2SO. This colorless liquid is an important polar aprotic solvent that dissolves both polar and nonpolar compounds and is miscible in a wide range of organic solvents as well as water. It has a distinctive property of penetrating the skin very readily, allowing the handler to taste it. Its taste has been described as oyster- or garlic-like. Production Dimethyl sulfoxide is a by-product of wood pulping. One of the leading suppliers of DMSO is the Gaylord Chemical Corporation in the USA. Solvent DMSO is an important polar aprotic solvent. It is less toxic than other members of this class such as dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, HMPA. Because of its excellent solvating power, DMSO is frequently used as solvent for chemical reactions involving salts. Because DMSO is only weakly acidic, it tolerates relatively strong bases. A practical problem with DMSO as a solvent is its high boiling point, thus its solutions are not typically evaporated. Instead, reactions conducted in DMSO are often diluted with water to isolate organic products. DMSO is an effective paint stripper, being safer than many of the others such as nitromethane and dichloromethane. In its deuterated form, i.e. DMSO-d6, it is a useful but expensive solvent for NMR spectroscopy, again due to its ability to dissolve a wide range of analytes and its own simple spectrum. Disadvantages to the use of DMSO-d6 are its high viscosity, which broadens signals, and high boiling point, which interferes with sample recovery from the NMR solvent. Often it is used with deuterochloroform, because the 1:1 mixture has a low viscosity. Reactions The sulfur center in DMSO is nucleophilic toward soft electrophiles and the oxygen is nucleophilic toward hard electrophiles. The methyl groups of DMSO are somewhat acidic in character (pKa=35) due to the stabilization of the resultant carbanion by the S(O)R group. DMSO reacts with methyl iodide to form a sulfoxonium salt [(CH3)3SO] I, which can be deprotonated with sodium hydride to form the sulfur ylide: (CH3)2SO + CH3I ¨ [(CH3)3SO]I [(CH3)3SO]I + NaH ¨ [(CH3)2CH2SO + NaI + H2 In organic synthesis, DMSO is used as an oxidant,[1] such as the Pfitzner-Moffatt oxidation and the Swern oxidation.[2] Products of ozonolysis, trioxolanes, are quenched with dimethyl sulfide to produce aldehydes and DMSO. Biology DMSO is used in the PCR reaction to inhibit secondary structures in the DNA template or the DNA primers. It is added to the PCR mix before reacting, where it interferes with the self-complementarity of the DNA, allowing otherwise troublesome reactions to occur. However, use of DMSO in PCR increases the mutation rate. DMSO also sees use as a cryoprotectant, added to cell media in order to prevent the cells dying as they are frozen. Approximately 10% may be used with a slow-freeze method, and the cells may be frozen at -20‹ C or stored in liquid nitrogen safely. Medicine In cryobiology DMSO has been used as a cryoprotectant and is still an important constituent of cryoprotectant vitrification mixtures used to preserve organs, tissues, and cell suspensions. Without it, up to 90 percent of frozen cells will become inactive. It is particularly important in the freezing and long-term storage of embryonic stem cells and hematopoietic stem cells, which are often frozen in a mixture of 10% DMSO and 90% fetal calf serum. As part of an autologous bone marrow transplant the DMSO is re-infused along with the patient's own hematopoietic stem cells. Use of DMSO in medicine dates from around 1963, when a University of Oregon Medical School team, headed by Stanley , discovered it could penetrate the skin and other membranes without damaging them and could carry other compounds into a biological system. In a 1978 study at the Cleveland Clinic Foundation in Cleveland, Ohio, researchers concluded that DMSO brought significant relief to the majority of the 213 patients with inflammatory genitourinary disorders that were studied. They recommended DMSO for all inflammatory conditions not caused by infection or tumor in which symptoms were severe or patients failed to respond to conventional therapy. Some people report an onion- or garlic-like taste after touching DMSO. (Onion and garlic also derive their stinginess from sulfoxides syn-propanethial-S-oxide and allicin.) In the medical field DMSO is predominantly used as a topical analgesic, a vehicle for topical application of pharmaceuticals, as an anti-inflammatory and an antioxidant. It has been examined for the treatment of numerous conditions and ailments. The Food and Drug Administration (FDA) has approved DMSO usage only for the palliative treatment of interstitial cystitis. Also, DMSO is commonly used in the veterinary field as a liniment for horses. Because DMSO increases the rate of absorption of some compounds through organic tissues including skin, it can be used as a drug delivery system. Dimethyl sulfoxide dissolves a variety of organic substances, including carbohydrates, polymers, peptides, as well as many inorganic salts and gases. Loading levels of 50-60 wt.% are often observed vs 10-20 wt.% with typical solvents. For this reason DMSO plays a role in sample management and High-throughput screening operations in drug design.[3] History in Medicine On September 9, 1965, the Wall Street Journal reported the death of an Irish woman after undergoing DMSO treatment for a sprained wrist [4] Clinical research using DMSO halted and did not begin again until the National Academy of Sciences (NAS) published findings in favor of DMSO in 1972.[citation needed] In 1978, the FDA approved DMSO for treating interstitial cystis. In 1980, Congress held hearings on claims that the FDA was slow in approving DMSO for other medical uses. In 2007, the FDA granted " fast track " designation on clinical studies of DMSO's use in reducing brain tissue swelling following traumatic brain injury. > > what is dmso > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 3, 2008 Report Share Posted March 3, 2008 > > Now wait a minute Daddybob! DMSO is a bi-product of the paper industry but it is derived from PINE trees. It is considered a solvent, No reason to jump on DB Micki, let's calm down and back up the bus here please. Also please keep in mind that WATEr is a SOLVENT, so is ALCOHOL. So even though it sounds impressive and has great shock value, the term solvent is not to be thought of as anything more than a substance in which some, not all, other substances will dissolve. A Wkipedia serach will help with terminology. Garnet Quote Link to comment Share on other sites More sharing options...
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