Epigenetics: DNA methylation profiling of human chromosomes 6, 20 and 22

[Guest guest]

Impact of nearby Genes can be shut of by a methyl group.

This my result in malfunction or illness.

The metod used

http://www.nature.com/ng/journal/vaop/ncurrent/abs/ng1909.html

DNA methylation profiling of human chromosomes 6, 20 and 22.

Stephan Beck, one of the researcher

http://www.sanger.ac.uk/Teams/Team50/

HEP http://www.sanger.ac.uk/PostGenomics/epigenome/

Source: Ny Teknik 8 Nov 2006(In swedish)

http://www.nyteknik.se/art/47838

I may have used wrong words in my attempt to translate the swedish

newspaper.

I would accept a pdf of the orignale article(nature).

In December of Nature Genetics they publish the first part of a genemap

that

may explain how new inhirited 'illnes' can be without prior faults in

our genes.

From research in European project Human Epigenomic Project, HEP

They have profiled the chromosmes 6,20,22. And 1/6 of the genes may have

changed

their activity due to external factors and this change may be passed on

(inherited).

the metod they use is called methylation.

This is a chemical process and when the methyl group (CH3) is added

to DNA sequense this results in that genes nearby can't be read.

They are shut of. The result of a shut off gene may result in

illnes/malfunction.

After 2 000 000 mesurements of methylation i 12 different kind of tissue

Heart, liver, muscle ...

Teh researcher state that the change is not correlated to sex and age

but different kind

tissue behave different.

/Per