CROHNS AND PEUDOMONAS

[Guest guest]

ALL,

Just read this article:

Pseudomonas fluorescens encodes the Crohn's disease-associated I2

sequence and T-cell superantigen.

Commensal bacteria have emerged as an important disease factor in

human Crohn's disease (CD) and murine inflammatory bowel disease (IBD)

models. We recently isolated I2, a novel gene segment of microbial

origin that is associated with human CD and that encodes a T-cell

superantigen. To identify the I2 microorganism, BLAST analysis was

used to identify a microbial homologue, PA2885, a novel open reading

frame (ORF) in the Pseudomonas aeruginosa genome. PCR and Southern

analysis identified Pseudomonas fluorescens as the originating species

of I2, with homologues detectable in 3 of 13 other Pseudomonas

species. Genomic cloning disclosed a locus containing the full-length

I2 gene (pfiT) and three other orthologous genes, including a

homologue of the pbrA/pvdS iron response gene. CD4(+) T-cell responses

to recombinant proteins were potent for I2 and pfiT, but modest for

PA2885. pfiT has several features of a virulence factor: association

with an iron-response locus, restricted species distribution, and

T-cell superantigen bioactivity. These findings suggest roles for pfiT

and P. fluorescens in the pathogenesis of Crohn's disease.

Link follows:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & dopt=Abstra\

ct & list_uids=12438326

Given that I have both, Crohns and a sinus pseudomona infection, if I

take care of the pseudomona infection, would that mean Crohn's would

also be cured????

Anyone experienced both anf the AB therapy?

I am seeing my ID doc in a few hours to see about IV antibiotic for

the pseudomona infection, which is getting quite problematic.

Thanks to all who have sent suggestions: I will ask about the BETADYNE

solution irrigation and see what she says. I am going armed with all

your printed comments...!!!!

Best to all,

ny