Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 I never got a noticable boost from doxy, but I felt that it was maybe holding things steady when I was on i.v. which meant it was in my blood stream for 6 hours a day or so. The problem was, I became so horribly photo sensitive. So badly sunburned even though I tried my best to stay covered in the sun, wore hats & gloves, etc. Just from driving with fingerless gloves, my finger tips were constantly blistered. And my nose was raw, and the tops of my feet we so painful, because who wants to wear socks all the time in San Diego? But anyway, I've thought about going on tetracyline for it's bone pentration potential, but know it's not even as powerful as doxy. Do you think taking it 4 times a day would make up for that? And do you think there's a possiblity that doxy could cause the photosensitivity but tetracycline wouldn't in some people? I just got sick of being crispy fried, and I still have some skin discolorations from it. It's one reason I haven't gotten really serious about the tetracycline. <usenethod@...> wrote: > Peopl spend 20, 30 50 thousand dollars on their own health care to > avoid death if they have to.> > In the case of animals- every owner has a finite $ amount they'll > spend.> They get put down if they get too expensive.Yeah. You can give a horse orals though, can't you? I mean at worst you could lace their fodder and keep them from grazing? I don't know if doxy's safe for horses, but I spent $150 for 50 g of it, 125 days' worth at 400 mg /d.I think tetracycline is far cheaper, but it doesn't have the sustained blood levels unless you administer it 4x a day; at least that's so for humans. To suppress physiologically abx resistant cells, you'd want high blood levels 24/7, like you get from doxy. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 29, 2006 Report Share Posted October 29, 2006 This orse was on large doses of IV Oxytetracycline to no avail. And DOxy is given orally to horses (in large doses) for an extended period for Lyme. (and yes that's cheaper) I'll ket you know how it goes on IV Baytril. Barb > > > > Peopl spend 20, 30 50 thousand dollars on their own health care to > > avoid death if they have to. > > > > In the case of animals- every owner has a finite $ amount they'll > > spend. > > They get put down if they get too expensive. > > > > Yeah. > > You can give a horse orals though, can't you? I mean at worst you > could lace their fodder and keep them from grazing? I don't know if > doxy's safe for horses, but I spent $150 for 50 g of it, 125 days' > worth at 400 mg /d. > > I think tetracycline is far cheaper, but it doesn't have the > sustained blood levels unless you administer it 4x a day; at least > that's so for humans. To suppress physiologically abx resistant > cells, you'd want high blood levels 24/7, like you get from doxy. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 29, 2006 Report Share Posted October 29, 2006 I'm not sure, but I think doxy may be reputed the worst as far as phototoxicity. There are even papers about how it works, but they are from the 70s and I havent dug up the full texts. I just use SPF 40 sun lotion... seems to help. Doxy and mino's superiority (over tet) in getting into the brain is I think pretty clear. But I don't think their longer half-life in the blood has much to do with that. Basically, as best I can figure out, tet is just cleared faster, so that taking ~300 mg of tet 4 times a day is just like taking 300 mg of doxy once a day - at least in terms of what's in your blood (brain, etc are another story). So, considering the way tet is taken (4x daily), it's as though the serum half life were " effectively " the same. What makes mino and doxy get into the brain so well might be different from what gets things into bone. I don't know what the barrier is to stuff getting into the bone, do you? I really don't get what the whole thing is about. If you can find any abstracts on which tetracyclines get into the bone best, I'd be glad to send you pdfs. > > I never got a noticable boost from doxy, but I felt that it was maybe holding things steady when I was on i.v. which meant it was in my blood stream for 6 hours a day or so. The problem was, I became so horribly photo sensitive. So badly sunburned even though I tried my best to stay covered in the sun, wore hats & gloves, etc. Just from driving with fingerless gloves, my finger tips were constantly blistered. And my nose was raw, and the tops of my feet we so painful, because who wants to wear socks all the time in San Diego? > > But anyway, I've thought about going on tetracyline for it's bone pentration potential, but know it's not even as powerful as doxy. Do you think taking it 4 times a day would make up for that? And do you think there's a possiblity that doxy could cause the photosensitivity but tetracycline wouldn't in some people? > > I just got sick of being crispy fried, and I still have some skin discolorations from it. It's one reason I haven't gotten really serious about the tetracycline. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 30, 2006 Report Share Posted October 30, 2006 I have this interesting book on a doctors experiences in treating infections.They alway's use tetyracycline because regardless of the organisms the small benefits that mino or doxy show in the antibiotic disc tests, the administration of upto 2 grams a day of tetra more than compensates. So it's a drug used in combo's in serious infections, with good results to show for it.Also a bone infection strictly growing ecoli sounds like someone is ignoring something IMO. It sounds like the avoidance of normal flora looking for the exotic .. This may explain why the results of the therapy are ifffy..I would also be tempted to give the horse some combo treatments as opposed to single agent therapy for a documented bone infection. > > > > I never got a noticable boost from doxy, but I felt that it was > maybe holding things steady when I was on i.v. which meant it was in > my blood stream for 6 hours a day or so. The problem was, I became > so horribly photo sensitive. So badly sunburned even though I tried > my best to stay covered in the sun, wore hats & gloves, etc. Just > from driving with fingerless gloves, my finger tips were constantly > blistered. And my nose was raw, and the tops of my feet we so > painful, because who wants to wear socks all the time in San Diego? > > > > But anyway, I've thought about going on tetracyline for it's > bone pentration potential, but know it's not even as powerful as > doxy. Do you think taking it 4 times a day would make up for that? > And do you think there's a possiblity that doxy could cause the > photosensitivity but tetracycline wouldn't in some people? > > > > I just got sick of being crispy fried, and I still have some > skin discolorations from it. It's one reason I haven't gotten really > serious about the tetracycline. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 30, 2006 Report Share Posted October 30, 2006 I'm surprised the sun block helped you. Didn't help me at all. I was obviously just extremely sensitive to the doxy. Unfortunately, I could never take mino long enough to see if I had photosensitivity issues with it. My reaction to mino was so severe, that's when I discovered that it can induce pseudotumor cerebri (ICH) in people, even causing blindness. I had the symptoms of PTC for sure when on mino, and the more I read about it, the more convinced I became that perhaps I already had some kind of mild case of it (and perhaps that's why I react so badly to the mino in the first place which aggravated and made it much worse). I don't know if Benicar actually affects the fluid, but the fact that it seems to help with brain inflammation in people with SARS, etc., seems to indicate it's removing pressure one way or another. And I'm sure that's why the Benicar seems to help my head so much, reducing anxiety, allowing me to think more clearly, etc..Unfortunately, other physical symptoms of inflammation seem to be increasing lately. Hip pain is the latest. And now recently the return of the migraines, although that may have something to do with my sinuses being more inflammed/infected. You know, I think the slightest change in pressure of any kind can really affect things. At least for me. Many years ago I had a herniated disc in my back, and it took me a long time to realize that my back got much worse when my digestion slowed down. Staying regular meant my back would stay okay. Constipation was sure to put it out. My doc said that it was impossible, no relationship between a spinal disc and the colon, but I know for a fact that there was a connection. Once I figured it out, from then on, during my PT & rehab and later, I made sure that I never allowed myself to get constipated, because the severity of the back pain that came with it was something I definitely wanted to avoid. My back's been great ever since. Only recently, with some of the drugs I'm on, things have slowed down again, and I have already had some minor back episodes. All I have to do is get myself regular and the back pain goes away. The body's a very sensitive balance, apparently. It's funny to me, because something like a slightest change in pressure, either barometric pressure, or inflammation from a monthly hormonal surge, or inflammation in my head and sinuses, can have such a huge impact on how I feel, and yet I can take massive amounts of numerous abx, and they don't seem to hurt me at all. Really weird. penny <usenethod@...> wrote: I'm not sure, but I think doxy may be reputed the worst as far as phototoxicity. There are even papers about how it works, but they are from the 70s and I havent dug up the full texts. I just use SPF 40 sun lotion... seems to help. Doxy and mino's superiority (over tet) in getting into the brain is I think pretty clear. But I don't think their longer half-life in the blood has much to do with that. Basically, as best I can figure out, tet is just cleared faster, so that taking ~300 mg of tet 4 times a day is just like taking 300 mg of doxy once a day - at least in terms of what's in your blood (brain, etc are another story). So, considering the way tet is taken (4x daily), it's as though the serum half life were "effectively" the same.What makes mino and doxy get into the brain so well might be different from what gets things into bone. I don't know what the barrier is to stuff getting into the bone, do you? I really don't get what the whole thing is about. If you can find any abstracts on which tetracyclines get into the bone best, I'd be glad to send you pdfs.>> I never got a noticable boost from doxy, but I felt that it was maybe holding things steady when I was on i.v. which meant it was in my blood stream for 6 hours a day or so. The problem was, I became so horribly photo sensitive. So badly sunburned even though I tried my best to stay covered in the sun, wore hats & gloves, etc. Just from driving with fingerless gloves, my finger tips were constantly blistered. And my nose was raw, and the tops of my feet we so painful, because who wants to wear socks all the time in San Diego?> > But anyway, I've thought about going on tetracyline for it's bone pentration potential, but know it's not even as powerful as doxy. Do you think taking it 4 times a day would make up for that? And do you think there's a possiblity that doxy could cause the photosensitivity but tetracycline wouldn't in some people?> > I just got sick of being crispy fried, and I still have some skin discolorations from it. It's one reason I haven't gotten really serious about the tetracycline.> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 30, 2006 Report Share Posted October 30, 2006 Penny: What was your dose, and your weight.? The phototoxicity effect rises when the dose exceeds the therapeutic dose/Kg of body weight... or duration is extended. Which in Doxy's case is 5mg/Kg of body weight. I was on Doxy- managed to take the therapeutic dose for almost a month before I got the phototoxicity.. but it was the nioght mares- progressing into daymare that really made me stop. Barb > > > > > > > I never got a noticable boost from doxy, but I felt that it was > maybe holding things steady when I was on i.v. which meant it was in > my blood stream for 6 hours a day or so. The problem was, I became > so horribly photo sensitive. So badly sunburned even though I tried > my best to stay covered in the sun, wore hats & gloves, etc. Just > from driving with fingerless gloves, my finger tips were constantly > blistered. And my nose was raw, and the tops of my feet we so > painful, because who wants to wear socks all the time in San Diego? > > > > But anyway, I've thought about going on tetracyline for it's > bone pentration potential, but know it's not even as powerful as > doxy. Do you think taking it 4 times a day would make up for that? > And do you think there's a possiblity that doxy could cause the > photosensitivity but tetracycline wouldn't in some people? > > > > I just got sick of being crispy fried, and I still have some > skin discolorations from it. It's one reason I haven't gotten really > serious about the tetracycline. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 30, 2006 Report Share Posted October 30, 2006 I don't remember. I was doing doxy in the i.v. balls, administered automatically. I was on it for quite a long time, like 3 months or so. It's possible I was taking too much. Had never heard of that possibility. I had no adverse effects other than the sunburn. To be honest, it didn't seem to have any great effect, other than I didn't backslide while on it. I do know that many drugs I take regularly seem to build up in my system or tissue, so that could make things worse over time. Like the mino. It stayed with me a long time. Even simple drugs like decongestants will have an effect on me way past the 4 hours they're supposed to work for, and if I take them every day for a few days, the effects are cumulative and last way longer. I've always been ultra sensitive to drugs like that, anything that says "may cause excitability in young children", lol! Antihistamines and sedatives make me completely wired, believe it or not. Something definitely backwards in my brain or somewhere. That's why I find it odd sometimes, that I can take SO much penicillin and other abx and feel so much better when other drugs affect me so adversely. The only abx I can't take are mino, imipenim, bactrim. I wonder sometimes if perhaps dehydration is partially partially responsible? Just speculation, but I.V. Imipenim made me deathly ill. Horrible, but I later learned that it should have been administered much more slowly with a lot more fluid and I might not have experienced those negative effects. But so many other drugs are bad news for me too. 2 days of Zoloft just about made me nuts. Actos made me very sick and took a month to recover. But most abx are nothing but good for me. That makes me wonder if I have such a high bacteria count that the abx just keep the balance somewhat normalized so that I'm functioning a little more normally. I really don't know. I just know that I am miserable very quickly without antibiotics of some sort. I'm lucky I've got a strong stomach now (after years of IBS) and a strong liver, I guess (knock on wood). My fear is that my doc will quit practicing, and I'll lose my source of abx. That ties me to this town, too. That's why I've got to get to the bottom of this and get the source of the infection taken care of. Unfortunately, some people with bone infections have to stay on a maintenance dose of abx for the rest of their lives. I hope I'm not one of those people. I'm so sick of looking at the table full of pills next to my bed. penny Barb Peck <egroups1bp@...> wrote: Penny:What was your dose, and your weight.?The phototoxicity effect rises when the dose exceeds the therapeutic dose/Kg of body weight... or duration is extended. Which in Doxy's case is 5mg/Kg of body weight.I was on Doxy- managed to take the therapeutic dose for almost a month before I got the phototoxicity.. but it was the nioght mares- progressing into daymare that really made me stop.Barb > > > --- In infections , Penny Houle > <pennyhoule@> wrote:> >> > I never got a noticable boost from doxy, but I felt that it was > maybe holding things steady when I was on i.v. which meant it was in > my blood stream for 6 hours a day or so. The problem was, I became > so horribly photo sensitive. So badly sunburned even though I tried > my best to stay covered in the sun, wore hats & gloves, etc. Just > from driving with fingerless gloves, my finger tips were constantly > blistered. And my nose was raw, and the tops of my feet we so > painful, because who wants to wear socks all the time in San Diego?> > > > But anyway, I've thought about going on tetracyline for it's > bone pentration potential, but know it's not even as powerful as > doxy. Do you think taking it 4 times a day would make up for that? > And do you think there's a possiblity that doxy could cause the > photosensitivity but tetracycline wouldn't in some people?> > > > I just got sick of being crispy fried, and I still have some > skin discolorations from it. It's one reason I haven't gotten really > serious about the tetracycline.> >> Quote Link to comment Share on other sites More sharing options...
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