Guest guest Posted October 21, 2006 Report Share Posted October 21, 2006 Thanks, Barb. I don't understand this one very well, but it is interesting in that the young foals fare worse. This fits with the fact that young people on quinolones get the ruptures while older people get the pain. Of course, the young ones may be more active. I am happy to say that my tendons are improving a lot. The Recuperation and magnesium taurinate seem to be the key. Also, the balance therapy has strengthened my muscles. I still have the vertigo and a sense of brain swelling. Tony's comments have encouraged me to call my doctor back and see if any detailed record of that throat culture exists. Thanks Barb and Tony, a > > a: > > Here's the best description I've found describing the mechanism behind > the tendon damage from this abx class. > > Barb > > > > 1: Cell Biol Toxicol. 2004 Feb;20(1):41-54. > Links > The effect of enrofloxacin on cell proliferation and proteoglycans in > horse tendon cells.Yoon JH, RL Jr, Khan A, Pan H, J, > Zhang J, Budsberg SC, Mueller PO, Halper J. > > The Soft Tissue Center, Department of Pathology, College of > Veterinary Medicine, University of Georgia, Athens, GA 30602-7388, > USA. > > Fluoroquinolone antibiotics have been used widely in humans and > domestic animals, including horses, because of their broad-spectrum > bactericidal activity, and relative safety. The use of > fluoroquinolones, however, is not without risk. Tendonitis and > spontaneous tendon rupture have been reported in people during or > following therapy with fluoroquinolones. We have studied the effects > of enrofloxacin, a fluoroquinolone antibiotic used commonly in > domestic animals, on tendon cell cultures established from equine > superficial digital flexor tendons. Effects on cell proliferation and > morphology were studied using cell counting and scanning electron > microscopy. Monosaccharide content and composition was determined by > gas chromatography-mass spectrometry analysis. Western and Northern > blot analyses were utilized to evaluate the synthesis and expression > of two proteoglycans, biglycan and decorin. Our data demonstrate that > enrofloxacin inhibits cell proliferation, induces morphological > changes, decreases total monosacharide content and alters small > proteoglycan synthesis at the glycosylation level in equine tendon > cell cultures. These effects are more pronounced in juvenile tendon > cells than in adult equine tendon cells. We hypothesize that > morphological changes and inhibition of cell proliferation are a > result of impaired production of biglycan and decorin, proteoglycans > involved in fibrillogenesis of collagen, the most important > structural component of the tendon of enrofloxacin-treated tendon > cells. Our findings suggest that fluoroquinolones should be used with > caution in horses, especially in foals. > > PMID: 15119847 [PubMed - indexed for MEDLINE] > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 21, 2006 Report Share Posted October 21, 2006 a Thank god you finally got it.It doesn't hurt to gather as much information as possable when you go into battle against the unknown. cheers > > Thanks, Barb. I don't understand this one very well, but it is > interesting in that the young foals fare worse. This fits with the > fact that young people on quinolones get the ruptures while older > people get the pain. Of course, the young ones may be more active. > > I am happy to say that my tendons are improving a lot. The > Recuperation and magnesium taurinate seem to be the key. Also, the > balance therapy has strengthened my muscles. > > I still have the vertigo and a sense of brain swelling. Tony's > comments have encouraged me to call my doctor back and see if any > detailed record of that throat culture exists. > > Thanks Barb and Tony, > a > > > > > > a: > > > > Here's the best description I've found describing the mechanism > behind > > the tendon damage from this abx class. > > > > Barb > > > > > > > > 1: Cell Biol Toxicol. 2004 Feb;20(1):41-54. > > Links > > The effect of enrofloxacin on cell proliferation and proteoglycans > in > > horse tendon cells.Yoon JH, RL Jr, Khan A, Pan H, J, > > Zhang J, Budsberg SC, Mueller PO, Halper J. > > > > The Soft Tissue Center, Department of Pathology, College of > > Veterinary Medicine, University of Georgia, Athens, GA 30602- 7388, > > USA. > > > > Fluoroquinolone antibiotics have been used widely in humans and > > domestic animals, including horses, because of their broad- spectrum > > bactericidal activity, and relative safety. The use of > > fluoroquinolones, however, is not without risk. Tendonitis and > > spontaneous tendon rupture have been reported in people during or > > following therapy with fluoroquinolones. We have studied the > effects > > of enrofloxacin, a fluoroquinolone antibiotic used commonly in > > domestic animals, on tendon cell cultures established from equine > > superficial digital flexor tendons. Effects on cell proliferation > and > > morphology were studied using cell counting and scanning electron > > microscopy. Monosaccharide content and composition was determined > by > > gas chromatography-mass spectrometry analysis. Western and Northern > > blot analyses were utilized to evaluate the synthesis and > expression > > of two proteoglycans, biglycan and decorin. Our data demonstrate > that > > enrofloxacin inhibits cell proliferation, induces morphological > > changes, decreases total monosacharide content and alters small > > proteoglycan synthesis at the glycosylation level in equine tendon > > cell cultures. These effects are more pronounced in juvenile tendon > > cells than in adult equine tendon cells. We hypothesize that > > morphological changes and inhibition of cell proliferation are a > > result of impaired production of biglycan and decorin, > proteoglycans > > involved in fibrillogenesis of collagen, the most important > > structural component of the tendon of enrofloxacin-treated tendon > > cells. Our findings suggest that fluoroquinolones should be used > with > > caution in horses, especially in foals. > > > > PMID: 15119847 [PubMed - indexed for MEDLINE] > > > Quote Link to comment Share on other sites More sharing options...
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