Guest guest Posted August 16, 2006 Report Share Posted August 16, 2006 Get your Id doctor to keep running cultures.I personally don't think anyone on the planet succesfully clears up a pseudomonas infection.I think without a doubt if your doing the correct therapy for the appropriate time frame you will fix your crohn's or should notice a huge improvement..there's possably a lot of necrotic sections of intestinal tract that needs attention, or long term you may turn over enough damaged cells IMO.. tony --- In infections , " J V " <jvitali@...> wrote: > > ALL, > > Just read this article: > > Pseudomonas fluorescens encodes the Crohn's disease-associated I2 > sequence and T-cell superantigen. > > Commensal bacteria have emerged as an important disease factor in > human Crohn's disease (CD) and murine inflammatory bowel disease (IBD) > models. We recently isolated I2, a novel gene segment of microbial > origin that is associated with human CD and that encodes a T-cell > superantigen. To identify the I2 microorganism, BLAST analysis was > used to identify a microbial homologue, PA2885, a novel open reading > frame (ORF) in the Pseudomonas aeruginosa genome. PCR and Southern > analysis identified Pseudomonas fluorescens as the originating species > of I2, with homologues detectable in 3 of 13 other Pseudomonas > species. Genomic cloning disclosed a locus containing the full- length > I2 gene (pfiT) and three other orthologous genes, including a > homologue of the pbrA/pvdS iron response gene. CD4(+) T-cell responses > to recombinant proteins were potent for I2 and pfiT, but modest for > PA2885. pfiT has several features of a virulence factor: association > with an iron-response locus, restricted species distribution, and > T-cell superantigen bioactivity. These findings suggest roles for pfiT > and P. fluorescens in the pathogenesis of Crohn's disease. > > Link follows: > > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? cmd=Retrieve & db=PubMed & dopt=Abstract & list_uids=12438326 > > Given that I have both, Crohns and a sinus pseudomona infection, if I > take care of the pseudomona infection, would that mean Crohn's would > also be cured???? > > Anyone experienced both anf the AB therapy? > > I am seeing my ID doc in a few hours to see about IV antibiotic for > the pseudomona infection, which is getting quite problematic. > > Thanks to all who have sent suggestions: I will ask about the BETADYNE > solution irrigation and see what she says. I am going armed with all > your printed comments...!!!! > > Best to all, > > ny > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 16, 2006 Report Share Posted August 16, 2006 Hi, Youve probably heard that M. avium complex has also been suggested as a cause of Crohns. I dont have much to contribute regarding your paper. But searching " related articles " showed some interesting other papers. There are like 100 abstracts in pubmed on the treatment of crohns with abx. Some report statistically significant changes in symptoms, others dont. It may be that the reason for this is that the therapies are on the borderline between being aggressive enough to make a measurable difference, and not being so. Or maybe there is some other reason. This one is the most dramatic I am aware of: a triple therapy tried out in Australia. Maybe you are already aware of this. 1: Dig Liver Dis. 2002 Jan;34(1):29-38. Treatment of severe Crohn's disease using antimycobacterial triple therapy--approaching a cure? Borody TJ, Leis S, Warren EF, Surace R. Centre for Digestive Diseases, Sydney, Australia. PMID: 11926571 Despite the title, the authors treat the mycobacterial theory as only a theory. They are sold on bacteria tho, and the results in the paper are fairly staggering, tho the number of patients is only 12 as I recall. This phase II study has led to a phase III study, led by P Gibson as I recall, which should be published anytime. If you register at pubmed you can get pubmed to email you whenever a new paper comes up under the search [gibson p]. Phase III means a ~100- patient study, the results of which, if conclusive, would probably mean the use of the therapy would start to spread pretty appreciably. But not all therapies that look hot in phase N continue to look hot in phase [N+1]. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 17, 2006 Report Share Posted August 17, 2006 > Youve probably heard that M. avium complex has also been suggested as > a cause of Crohns. In case I confused anybody, its specifically M avium variety paratuberculosis that has been a suspect in Crohn's. Thats known as MAP. I assume that MAP is probably a proper subset of MAC, which is the M avium - M intracellulare complex. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 17, 2006 Report Share Posted August 17, 2006 So I saw the ID doc yesterday. She said my pseudomona culture only showed up on broth and the Staph Aureus showed only scant growth. She thinks this is not unusual that most people have both of these bugs in the sinus, and that my problem is more chronic sinusistis due to allergies. She offered however to put me on an IV AB (starts with a CY... I forget the other syllables) for two weeks to see if symptoms improve. Then if they do, go for another week but not more than 3 weeks. She said that because I don't have a fever she is not overly concerned. She struck me as a bit flippant throughout the visit. My ENT did not provide bone culture from my recent surgery but she was unconcerned about getting a biopsy. Overall I did not feel reassured. I am tempted to go ahead with the IV AB for two weeks. I do have allergies and I am taking allergy shots weekly. Sinus dry up a bit for the first 4 days after injection but then they slowly become runny again and bloody at the same time... I can understand runny but bloody??? This is why I am puzzled by the ID Doc. She seems to think a bloody nose due to allergies is not uncommon... Any thoughts? Thanks and best to all, ny > > > > ALL, > > > > Just read this article: > > > > Pseudomonas fluorescens encodes the Crohn's disease-associated I2 > > sequence and T-cell superantigen. > > > > Commensal bacteria have emerged as an important disease factor in > > human Crohn's disease (CD) and murine inflammatory bowel disease > (IBD) > > models. We recently isolated I2, a novel gene segment of microbial > > origin that is associated with human CD and that encodes a T-cell > > superantigen. To identify the I2 microorganism, BLAST analysis was > > used to identify a microbial homologue, PA2885, a novel open reading > > frame (ORF) in the Pseudomonas aeruginosa genome. PCR and Southern > > analysis identified Pseudomonas fluorescens as the originating > species > > of I2, with homologues detectable in 3 of 13 other Pseudomonas > > species. Genomic cloning disclosed a locus containing the full- > length > > I2 gene (pfiT) and three other orthologous genes, including a > > homologue of the pbrA/pvdS iron response gene. CD4(+) T-cell > responses > > to recombinant proteins were potent for I2 and pfiT, but modest for > > PA2885. pfiT has several features of a virulence factor: association > > with an iron-response locus, restricted species distribution, and > > T-cell superantigen bioactivity. These findings suggest roles for > pfiT > > and P. fluorescens in the pathogenesis of Crohn's disease. > > > > Link follows: > > > > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? > cmd=Retrieve & db=PubMed & dopt=Abstract & list_uids=12438326 > > > > Given that I have both, Crohns and a sinus pseudomona infection, if > I > > take care of the pseudomona infection, would that mean Crohn's would > > also be cured???? > > > > Anyone experienced both anf the AB therapy? > > > > I am seeing my ID doc in a few hours to see about IV antibiotic for > > the pseudomona infection, which is getting quite problematic. > > > > Thanks to all who have sent suggestions: I will ask about the > BETADYNE > > solution irrigation and see what she says. I am going armed with all > > your printed comments...!!!! > > > > Best to all, > > > > ny > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 17, 2006 Report Share Posted August 17, 2006 Your lucky you even got as far as you did with your ID doctor. Most of them send a bus to your place with guys that put you in a straight jacket for suggesting what you just did. Most doctors ID in particular are really not stepping up and treating anyone, and when they do it's a pathetic attempt at treatment.They go with there favourite drug, which is absolutely useless 'ceftriaxone'..not good for pseudonomas, and only upsets staphs- basically resistance is built in 3 days with satphs and ceftriaxone. The fact that she buys your treatment of your allergies, 'surprises me'? Anyway's learn all you can and trust me when I say that the majority of autoimune people have pseudonomas/staph areus/or staph epi in the sinus. A healthy person has pretty much a wide spectrum of organisms, similar to what you'd find in a soil sample.I have seen over 100 cfs nasal bacteria samples, and the only fungus which you find occasionally is capable of standing the heat of a bad bacterium. > > > > > > ALL, > > > > > > Just read this article: > > > > > > Pseudomonas fluorescens encodes the Crohn's disease-associated I2 > > > sequence and T-cell superantigen. > > > > > > Commensal bacteria have emerged as an important disease factor in > > > human Crohn's disease (CD) and murine inflammatory bowel disease > > (IBD) > > > models. We recently isolated I2, a novel gene segment of microbial > > > origin that is associated with human CD and that encodes a T- cell > > > superantigen. To identify the I2 microorganism, BLAST analysis was > > > used to identify a microbial homologue, PA2885, a novel open reading > > > frame (ORF) in the Pseudomonas aeruginosa genome. PCR and Southern > > > analysis identified Pseudomonas fluorescens as the originating > > species > > > of I2, with homologues detectable in 3 of 13 other Pseudomonas > > > species. Genomic cloning disclosed a locus containing the full- > > length > > > I2 gene (pfiT) and three other orthologous genes, including a > > > homologue of the pbrA/pvdS iron response gene. CD4(+) T-cell > > responses > > > to recombinant proteins were potent for I2 and pfiT, but modest for > > > PA2885. pfiT has several features of a virulence factor: association > > > with an iron-response locus, restricted species distribution, and > > > T-cell superantigen bioactivity. These findings suggest roles for > > pfiT > > > and P. fluorescens in the pathogenesis of Crohn's disease. > > > > > > Link follows: > > > > > > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi? > > cmd=Retrieve & db=PubMed & dopt=Abstract & list_uids=12438326 > > > > > > Given that I have both, Crohns and a sinus pseudomona infection, if > > I > > > take care of the pseudomona infection, would that mean Crohn's would > > > also be cured???? > > > > > > Anyone experienced both anf the AB therapy? > > > > > > I am seeing my ID doc in a few hours to see about IV antibiotic for > > > the pseudomona infection, which is getting quite problematic. > > > > > > Thanks to all who have sent suggestions: I will ask about the > > BETADYNE > > > solution irrigation and see what she says. I am going armed with all > > > your printed comments...!!!! > > > > > > Best to all, > > > > > > ny > > > > > > Quote Link to comment Share on other sites More sharing options...
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