RE: Re: CROHNS AND PEUDOMONAS

[Guest guest]

was it any particular combo of triple abx or did it vary? <usenethod@...> wrote: Hi,Youve probably heard that M. avium complex has also been suggested as a cause of Crohns.I dont have much to contribute regarding your paper. But searching "related articles" showed some interesting other papers.There are like 100 abstracts in pubmed on the treatment of crohns with abx. Some report statistically significant changes in symptoms, others dont. It may be that the reason

for this is that the therapies are on the borderline between being aggressive enough to make a measurable difference, and not being so. Or maybe there is some other reason. This one is the most dramatic I am aware of: a triple therapy tried out in Australia. Maybe you are already aware of this.1: Dig Liver Dis. 2002 Jan;34(1):29-38. Treatment of severe Crohn's disease using antimycobacterial triple therapy--approaching a cure?Borody TJ, Leis S, Warren EF, Surace R. Centre for Digestive Diseases, Sydney, Australia. PMID: 11926571 Despite the title, the authors treat the mycobacterial theory as only a theory. They are sold on bacteria tho, and the results in the paper are fairly staggering, tho the number of patients is only 12 as I recall. This phase II study has led to a phase III study, led by P Gibson as I recall, which should be published anytime. If you register at pubmed you can

get pubmed to email you whenever a new paper comes up under the search [gibson p]. Phase III means a ~100-patient study, the results of which, if conclusive, would probably mean the use of the therapy would start to spread pretty appreciably. But not all therapies that look hot in phase N continue to look hot in phase [N+1].

[Guest guest]

Back in 1999 The Mayo clinic published their findings on a study carried out to identify the causes of chronic sinusitis .They found that even though bacteria could be cultured the actual cause was an unexpected response to fungi ..the fungi downgraded the immune system allowing other pathogens to grow …some info …Allergies are an inappropriate responses to stealth pathogens ..the IS is pushed into wound response ..listen to the audio section of my site ..,,

Many studies here at the Mayo Clinic have added evidence to our thinkingthat chronic rhinosinusitis is caused by an immune reaction to fungi in thenose. Our original study linking chronic rhinosinusitis to fungi in thenose, which was published in the Mayo Clinic Proceedings in September 1999,has been reproduced and confirmed by a sinus center in Europe (ENTUniversity Hospital in Graz, Austria).There are currently 16 studies at Mayo Clinic Rochester to furtherinvestigate the role of fungi in inflammatory diseases of the respiratorytract.In addition, researchers from the Allergic Diseases Research Laboratory at the Mayo Clinic in Rochester found that certain white blood cells

called T-Lymphocytes are reacting to the fungi and were producing the kind of inflammation we see in the sinuses, and that healthy people did

not react in that way. This work was presented at the 2001 Annual Meeting of the American Academy of Allergy, Asthma and Immunology

.

If you have chronic sinusitis—that is, a sinus inflammation that persistsfor three months or longer—we recommend that you see your personalphysician or an ear, nose and throat specialist (otorhinolaryngologist) forthe appropriate treatment for this disease. Many times the disease isassociated with asthma or allergies and treatment of those associatedproblems tends to help the chronic sinusitis.Antibiotics don’t help chronic sinusitis in the long run because they targetbacteria, which are not usually the cause of chronic sinusitis.Anti-histamines, nasal steroid sprays and systemic steroids are themainstays of treatment today, depending on the symptoms of the patient.Over-the-counter medications, including salt-water nasal washes and mistsprays, are useful in treating the symptoms of chronic sinusitis, but do noteliminate the inflammation.Dept of OtorhinolaryngologyMayo ClinicRochester, Minnesota

This latest report supports the link with CFS [ME] an

d fungal infectionhttp://news.bbc.co.uk/1/hi/health/3141773.stm

Stop press information http://www.sciencedaily.com/releases/2004/03/040324072619.htm

See Medline 12464951 for results of a study using antifungal drugs to treat sinusitis.

-----Original Message-----From: infections [mailto:infections ]On Behalf Of J VSent: 17 August 2006 13:34infections Subject: [infections] Re: CROHNS AND PEUDOMONAS

So I saw the ID doc yesterday. She said my pseudomona culture onlyshowed up on broth and the Staph Aureus showed only scant growth. Shethinks this is not unusual that most people have both of these bugs inthe sinus, and that my problem is more chronic sinusistis due toallergies. She offered however to put me on an IV AB (starts with aCY... I forget the other syllables) for two weeks to see if symptomsimprove. Then if they do, go for another week but not more than 3 weeks.She said that because I don't have a fever she is not overlyconcerned. She struck me as a bit flippant throughout the visit.My ENT did not provide bone culture from my recent surgery but she wasunconcerned about getting a biopsy. Overall I did not feel reassured. I am tempted to go ahead with the IV AB for two weeks. I do have allergies and I am taking allergy shots weekly. Sinus dry upa bit for the first 4 days after injection but then they slowly becomerunny again and bloody at the same time... I can understand runny butbloody??? This is why I am puzzled by the ID Doc. She seems to think abloody nose due to allergies is not uncommon... Any thoughts?Thanks and best to all,ny> >> > ALL,> > > > Just read this article:> > > > Pseudomonas fluorescens encodes the Crohn's disease-associated I2> > sequence and T-cell superantigen.> > > > Commensal bacteria have emerged as an important disease factor in> > human Crohn's disease (CD) and murine inflammatory bowel disease > (IBD)> > models. We recently isolated I2, a novel gene segment of microbial> > origin that is associated with human CD and that encodes a T-cell> > superantigen. To identify the I2 microorganism, BLAST analysis was> > used to identify a microbial homologue, PA2885, a novel open reading> > frame (ORF) in the Pseudomonas aeruginosa genome. PCR and Southern> > analysis identified Pseudomonas fluorescens as the originating > species> > of I2, with homologues detectable in 3 of 13 other Pseudomonas> > species. Genomic cloning disclosed a locus containing the full-> length> > I2 gene (pfiT) and three other orthologous genes, including a> > homologue of the pbrA/pvdS iron response gene. CD4(+) T-cell > responses> > to recombinant proteins were potent for I2 and pfiT, but modest for> > PA2885. pfiT has several features of a virulence factor: association> > with an iron-response locus, restricted species distribution, and> > T-cell superantigen bioactivity. These findings suggest roles for > pfiT> > and P. fluorescens in the pathogenesis of Crohn's disease.> > > > Link follows: > > > > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?> cmd=Retrieve & db=PubMed & dopt=Abstract & list_uids=12438326> > > > Given that I have both, Crohns and a sinus pseudomona infection, if > I> > take care of the pseudomona infection, would that mean Crohn's would> > also be cured????> > > > Anyone experienced both anf the AB therapy?> > > > I am seeing my ID doc in a few hours to see about IV antibiotic for> > the pseudomona infection, which is getting quite problematic.> > > > Thanks to all who have sent suggestions: I will ask about the > BETADYNE> > solution irrigation and see what she says. I am going armed with all> > your printed comments...!!!!> > > > Best to all,> > > > ny> >>