Guest guest Posted July 31, 2006 Report Share Posted July 31, 2006 Curr Eye Res (1992) 11: 843-8. The effect of chlorpromazine on endotoxin-induced uveitis in the rat. L Kasner, CC Chan, E Cordella-Miele, I GeryLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892. Chlorpromazine (CPZ) has been used extensively in the treatment of psychiatric disorders, and has recently been shown to possess systemic anti-inflammatory properties as well. To investigate the potential effects of CPZ on ocular inflammation, we evaluated its action on endotoxin-induced uveitis (EIU) in rats. At three different dosage levels, CPZ produced highly significant reductions in the mean aqueous aspirate inflammatory cell counts and histological inflammatory scores as compared to controls treated with vehicle only. Analysis of aqueous fluid demonstrated a similar decrease in protein concentration and phospholipase A2 (PLA-2) activity in the treated animals. The ability of CPZ to inhibit the development of EIU may be related to its properties as a calcium channel blocker and inhibitor of the enzyme phospholipase A2.[Pubmed Record - new window] Browse via Keywords: Chlorpromazine, CPZ, endotoxin-induced, uveitis, , EIU, psychiatric, inflammatori, aqueous, anti-inflammatori, disorders, ocular, possess, extensively, inflammatory, dosage, phospholipase, highli, potential, recently, treatment, evaluated, aspirate, phospholipas a2, scores, shown, A2, vehicle, reductions, histological, counts, treatment, PLA-2, fluid, rats, significant, blocker, decrease, channels, concentration, animals, calcium, Analysis, similar, ability, demonstrated, compared, inhibitor, inhibit, enzyme, cell, protein, Quote Link to comment Share on other sites More sharing options...
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