keep an eye out for daptomycin

[Guest guest]

Daptomycin, branded Cubicin, has apparantly been FDA approved since

2003. Its conceived as a last-line treatment for things like VRSA

(vanco-resistant MRSA).

This molecule apparantly causes ion fluxes across the bacterial

membrane. Its way too large to pass by the outer membrane of typical

gram-negatives, tho that may or may not be practicably " patchable " in

some way eg PMID 7868392.

Because this molecule is equally lethal to resting bacteria, its

possible it could be a real hammer as far as any disease that might be

caused by low-metabolic bacteria. We should all keep an eye out on

news/forums for unexpected results from people recovering from chronic

diseases after getting this in the hospital, or, on the other hand,

possibly getting very ill or even dying of a massive herx while

receiving it.

[Guest guest]

Good catch! <usenethod@...> wrote: Daptomycin, branded Cubicin, has apparantly been FDA approved since2003. Its conceived as a last-line treatment for things like VRSA(vanco-resistant MRSA).This molecule apparantly causes ion fluxes across the bacterialmembrane. Its way too large to pass by the outer membrane of typicalgram-negatives, tho that may or may not be practicably "patchable" insome way eg PMID 7868392. Because this molecule is equally lethal to resting bacteria, itspossible it could be a real hammer as

far as any disease that might becaused by low-metabolic bacteria. We should all keep an eye out onnews/forums for unexpected results from people recovering from chronicdiseases after getting this in the hospital, or, on the other hand,possibly getting very ill or even dying of a massive herx whilereceiving it.