a - Mg/quinos

[Guest guest]

a do you have any refs/elaboration on quinolone tendon damage

possibly being at least in part a function of Mg status?

I used to have muscle twitches (1000s/day) that would completely stop

immediately (for a month or so) whenever I recieved an intravenous

Meyers cocktail, which I understand contains alot of Mg. This

phenomenon *may not* represent correction of Mg deficiency, as it

could also be that my Mg status was perfectly fine, but that the

presence of *super-normal* Mg was somehow able to stop the twitching.

Nevertheless, I think correction of Mg deficiency has a much greater

ring of plausibility.

At that point in my history, oral Mg did not affect my twitches

discernably. After much strong abx treatment got rid of most of my

illness, I now have only a dozen twitches a day, and these are

suppressed as long as I take ~200 mg of oral Mg a couple times a

week. Thus, if in fact I did have Mg deficiency in the past, it might

well be that my Mg status remains marginal at present.

I finally looked into intracellular Mg status in CFS. Pubmed yields

various findings on red cell Mg. This JCFS paper claims (p 17) that

red cell Mg testing may not be valid, and gives 2 refs on that which

I may or may not look up sometime. The same paper cites unpublished

claims that CFSers are Mg deficient according to a different assay.

(Without further info I cannot assume that unpublished results have

high validity.) Retention of Mg after IV loading seems to be the gold

standard test according to this JCFS paper.

http://www.exatest.com/PDF%20Files/15.%20Chronic%20Fatigue%20Syndrome%

20.PDF

Also interesting re that gold standard is this rather confusing

pubmed abstract, and the one after:

97 patients (25 per cent males, ages ranging from 14 to 73 years,

median 38 years) with complaints of chronic fatigue (chronic fatigue

syndrome, fibromyalgia or/and spasmophilia) have been enrolled in a

prospective study to evaluate the Mg status and the dietary intake of

Mg. An IV loading test (performed following the Ryzen protocol)

showed a Mg deficit in 44 patients. After Mg supplementation in 24

patients, the loading test showed a significant decrease (p = 0.0018)

in Mg retention. Mean values of serum Mg, red blood cell Mg and

magnesuria showed no significant difference between patients with or

without Mg deficiency. No association was found between Mg

deficiency, CFS or FM. However serum Mg level was significantly lower

in the patients with spasmophilia than in the other patients.

PMID: 9513929 [PubMed - indexed for MEDLINE]

Red blood cell magnesium concentrations were measured in samples from

89 patients who fulfilled the diagnostic criteria for chronic fatigue

syndrome and the results compared to those found in an age and sex

matched group selected from the normal population. No significant

difference was found. Six patients were further investigated using a

magnesium loading test to determine if there was any evidence of

magnesium deficiency associated with this disorder. None was found.

There is therefore no indication for the use of magnesium therapy in

the management of this condition.

PMID: 7832571 [PubMed - indexed for MEDLINE]

Further papers on Mg status in CFS/etc, and further work on the

validity of the Mg lodaing/retention assay, are here:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

db=pubmed & cmd=Display & dopt=pubmed_pubmed & from_uid=9513929