Guest guest Posted June 13, 2006 Report Share Posted June 13, 2006 Robyn are you saying you picked up a symptom exacerbation from tini, and it did not resolve even tho you stopped tini? Sorry to hear it. I just wanted to verify that for my information, as I dont exactly promote nitroimidazoles, but I do tell people about their advantages and how they seemed to cause my remission from severe disease, and I try at the same time to tell everything I know about the disadvantages (for example I know Sues daughter experienced lasting adverse effects from it). Hmm Jelly I read your description. Are you saying you are off abx most of the time, and just recently did these 4 doses? And now you say you feel better after your brief usages of these low doses - once the accompanying exacerbations are over, that is? It all does sound rather herxy to me. I cant give you that biochem-based opinion, as I mentioned, because I havent found a consensus Kd value. But even if I do eventually make that calculation, its just a model and its answer would not be a final one. There could certainly be things we dont understand about the pathogenesis or the biochem of the antibiotics/bacteria. For example, I dont know whether it is still believed, or not, that tetracyclines are actively concentrated by bacteria. But the latest source I read (not very late) said they probably were, and that no one knows what the bacterial pump protein that takes them up is " supposed " to take up (its obviously not intended to take up tetracyclines). If, say, you were to have an infection with bacteria that have 10x excess amounts of that pump, that might cause them to die at low concentrations of mino. And whether that speculation is a plausible one, no one really knows, because no one knows what that pump is there for. I mean, I wouldnt bet on it, but I could also pour myself a coke and sit and think of 5 more scenarios of that sort in a couple hours. Are any of them true, no idea, maybe in 100 years all this stuff will be sorted out. I cant wait to see what we find out by the time I'm 70. Till then, we all just try to fit to the facts and do the most reasonable things we can to squoosh our putative gross lil enemies (or universal native blood bacteria which our lymphocytes tragically hyperreact to, or both, or neither, or whatever crazy thing a particular one of us has). My point is just that theres alot we dont know - more than I implied in my first post on this thread, I must say. Last summer I used to have major reactions (extreme sleepiness, etc) to low doses of antidepressants that at least some people (apparantly including my doctor at the time) dont consider possible. I dont know whether those people have a close biochemical workup of that view or are just asserting " common sense. " Close workup or no, obviously no one understands every move that can be made by the brain, and therefore no perfect or even nearly-perfect workup is possible. And I know I've fooled myself about a few things before in the past like almost anyone has, but also that I definitely wasnt fooling myself about these particular experiences. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 13, 2006 Report Share Posted June 13, 2006 > Hmm Jelly I read your description. Are you saying you are off abx most > of the time, and just recently did these 4 doses? And now you say you > feel better after your brief usages of these low doses - once the > accompanying exacerbations are over, that is? Yes, yes, YES, that is EXACTLY what I am saying. > > It all does sound rather herxy to me. I cant give you that > biochem-based opinion, as I mentioned, because I havent found a > consensus Kd value. But even if I do eventually make that calculation, > its just a model and its answer would not be a final one. There could > certainly be things we dont understand about the pathogenesis or the > biochem of the antibiotics/bacteria. For example, I dont know whether > it is still believed, or not, that tetracyclines are actively > concentrated by bacteria. But the latest source I read (not very late) > said they probably were, and that no one knows what the bacterial pump > protein that takes them up is " supposed " to take up (its obviously not > intended to take up tetracyclines). If, say, you were to have an > infection with bacteria that have 10x excess amounts of that pump, > that might cause them to die at low concentrations of mino. And > whether that speculation is a plausible one, no one really knows, > because no one knows what that pump is there for. If you ever get anything in the way of a brain storm from the Coke bubbles, let us know:} Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 13, 2006 Report Share Posted June 13, 2006 > Robyn are you saying you picked up a symptom exacerbation from tini, > and it did not resolve even tho you stopped tini? Sorry to hear it. I > just wanted to verify that for my information, as I dont exactly > promote nitroimidazoles, but I do tell people about their advantages > and how they seemed to cause my remission from severe disease, and I > try at the same time to tell everything I know about the disadvantages > (for example I know Sues daughter experienced lasting adverse effects > from it). Hi ... Yes, at the time, I had minimal inflammation in both knees. Within a couple of hours of the first dose of Tini, I had a marked increase in pain and swelling which was even worse the following day. I did take a second dose but things plummeted even more. I was unable to walk etc. While my knees did improve a small amount, they never have been even close to the shape they were in pre-Tini...over 3 years now. Robyn Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 14, 2006 Report Share Posted June 14, 2006 Interesting. Just talked to someone today who said she took flagyl and two things happened. One, drainage of pus subsided, but her joints started hurting like crazy. penny Hi ...Yes, at the time, I had minimal inflammation in both knees. Within a couple of hours of the first dose of Tini, I had a marked increase in pain and swelling which was even worse the following day. I did take a second dose but things plummeted even more. I was unable to walk etc. While my knees did improve a small amount, they never have been even close to the shape they were in pre-Tini...over 3 years now.Robyn Quote Link to comment Share on other sites More sharing options...
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