Guest guest Posted June 5, 2006 Report Share Posted June 5, 2006 Check this out. http://www.artemisandco.com/johnweb/bacteria.htm Anyone know Graham from Australia? Interesting stuff. a > and all, > > Do you have any studies that would suggest that any of the tick- borne > pathogens might disregulate stat 1? > > > > a No. Indeed, I havent seen many examples where the immune-derailing molecular acts of bacteria have been fully uncovered. For this reason, the new Yersinia molecule recently posted about here is interesting. Another known anti-immune molecule is CPAF, a protein secreted by chlamydiae that cuts up a human protein that figures in immune activation control. But more of these things seem to be unknown than known. For example, Zhong showed recently that chlamydiae actively prevent apoptosis of the cells they infect, but so far he cant find the molecule that does it. Presumably it is some protein that chlamydiae secrete into the host cell. Similarly, macrophages infected by M. tuberculosis arent as immunoactivated as they should be. Mtb " soothes " them, which helps Mtb survive. But no one knows exactly how Mtb accomplishes this. I just started learning about the STAT1 stuff last week, and have been discussing it with ne at cfs_research. I dont really know enough to say whether the 91/84-STAT1 deficiency is " microbe- directed " - ie, a result of an immune-system-blocking microbial molecule. As far as I know (which is not very far at all), the STAT deficiency conceivably could instead be a host-directed response to a microbe (or to something else). Quote Link to comment Share on other sites More sharing options...
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