Guest guest Posted May 31, 2006 Report Share Posted May 31, 2006 I'm interested in maybe combining quinolones with nitroimidazoles, as DNA damage is probably an important mechanism of the latter, and I hear DNA gyrase is needed for the SOS polymerase to scan the chromosome for DNA damage. (I havent confirmed this yet.) DNA gyrase I understand to be the target of quinolone abx. I havent looked into the possible safety of this combo at all yet. If anyone has reason to think it might be a bad idea, let me know. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 31, 2006 Report Share Posted December 31, 2006 Happy New Year, a! The reason people object is that you put all kinds of drugs and substances in the same basket as if they ALL almost inevitably cause tendon damage. Mefloquine (Lariam for eg) is not a quinolone but a quinolone derivative and I have never seen tendon damage listed as a potential side effect. You are so emotive about it, you talk of HUGE RISKS as if you had figures to back up your claims and I don't think you do. Note: I am not saying people should NOT be aware that some people experience tendon problems when on fluoroquinolone abx but I just don't think your campaign against ALL quinolones (especially the derivatives and the other substances related to quinolones) is soundly based on facts re: their potential for tendon damage. Nelly [infections] Re: Yasko, infection, antibiotics attn Bob Hi Barb,I agree with you. I didn't say no one should ever take quinolones. I said all quinolones are toxic. So is all aspirin. The crime is that MDs are not aware of the huge risks and do not try other antibiotics first, nor do they adequately warn their patients.The only reason I waste my time posting and reposting about quinolones is that I would hate for what happened to me and thousands of other patients to happen to anyone whom I could warn of the risk.Buyer beware. If you must take quinolones, including samento and Lariam, try to increase your magnesium which research seems to indicate is the missing predictor of damage. Quinolone damage is CELL damage, not liver damage. Those who are harmed are those with low magnesium levels, as far as we now know. This puts cfs and Lyme patients at increased risk, especially when joint pain and CNS damage are already the signs of LYME and CFS. This makes the risks of quinolones much greater, as they cannot be spotted. Also, remember that some of us with even a few days of quinolones do not recover for years.If you are sick of me posting this, then just agree with me. LOLa Carnes>> a:> > Some people can take them- some can't. There are some people who > think all abx are toxic to the body.> > Maybe someday we'll have the technology to run a P450 panel on > everyone before they take abx- so we'll know which ones will be > detrimental to us BEFORE we take them.> Right now it's a crap shoot- and everyone must decide the risks for > themselves. I've taken plenty - but am vigilant when I do so > hopefully stop something before it's too late.> > Not everyone's body metabolizes the same.> > P450 profiles would be a great thing. I know they can do it now, but > it's not a wide spread practice.> > ALL ANTIBIOTICS have a side effect. You have to weigh them all.> > Barb Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 1, 2007 Report Share Posted January 1, 2007 Let me restate that I never say a patient should never take a quinolone. What I try to do is repeat the warnings I wish to God someone had told me before I took 2 months of quinolones and ended up in a wheel chair at times and almost unable to walk. Do I group things together that are not the same? I have heard from many patients like myself who are unable to tolerate samento, cat's claw, or, in my case, even quinine water. No, there are no studies because the studies on non prescription products are few and far between. These herbals seem to cause tendon pain and damage in SOME patients. But far more serious is the CNS damage that quinolones and their relatives can cause. Is Lariam dangerous? Is plaquinil dangerous? Yes, but not because they cause tendon damage. Their risk is Lariam can harm the central nervous system. Plaquinil can cause blindness. So, I will continue to post on this. If you want far more detailed explanations of risks for these quinolone RELATED drugs do your own google search. I try not to waste people's time or bore people. Here is a brief email I posted a year or so ago to a doctors' list Nelly and I are both on. It is in regard to Lariam damage to the CNS and a report on CNN. You may not have seen it in France as it pertained to US soldiers in the Iraq War. (I can email the transcript to anyone who is interested, but it is long, and I would rather not post it here for that reason.) -a Carnes The CNN segment on a Zahn this evening was on CNS damage caused by Lariam, a quinolone from Roche used to treat malaria. The soldiers were given this once a week for several months. Lariam, made by Roche, carries a warning on its insert regarding CNS damage. This latest report by CNN news is stunning. I will forward the transcript as soon as it is posted at CNN. This sad news is just another piece in the horrifying puzzle of quinolone Russian roulette. Our problem, as I see it, is to be sure that we are not seeing anxiety attacks, " Lyme rage, " and severe suicidal depression - not caused by Lyme at all but by the quinolones we are taking to treat the Lyme or babesia. Don't write me back with any Lyme rage attacks until you see the transcript. Please. a Carnes > > Happy New Year, a! > > The reason people object is that you put all kinds of drugs and substances in the same basket as if they ALL almost inevitably cause tendon damage. > > Mefloquine (Lariam for eg) is not a quinolone but a quinolone derivative and I have never seen tendon damage listed as a potential side effect. > > You are so emotive about it, you talk of HUGE RISKS as if you had figures to back up your claims and I don't think you do. Note: I am not saying people should NOT be aware that some people experience tendon problems when on fluoroquinolone abx but I just don't think your campaign against ALL quinolones (especially the derivatives and the other substances related to quinolones) is soundly based on facts re: their potential for tendon damage. > > Nelly > > > [infections] Re: Yasko, infection, antibiotics attn Bob > > > Hi Barb, > I agree with you. I didn't say no one should ever take quinolones. I > said all quinolones are toxic. So is all aspirin. The crime is that > MDs are not aware of the huge risks and do not try other antibiotics > first, nor do they adequately warn their patients. > > The only reason I waste my time posting and reposting about > quinolones is that I would hate for what happened to me and thousands > of other patients to happen to anyone whom I could warn of the risk. > > Buyer beware. If you must take quinolones, including samento and > Lariam, try to increase your magnesium which research seems to > indicate is the missing predictor of damage. Quinolone damage is CELL > damage, not liver damage. Those who are harmed are those with low > magnesium levels, as far as we now know. This puts cfs and Lyme > patients at increased risk, especially when joint pain and CNS damage > are already the signs of LYME and CFS. This makes the risks of > quinolones much greater, as they cannot be spotted. Also, remember > that some of us with even a few days of quinolones do not recover for > years. > > If you are sick of me posting this, then just agree with me. LOL > > a Carnes > > > > a: > > > > Some people can take them- some can't. There are some people > who > > think all abx are toxic to the body. > > > > Maybe someday we'll have the technology to run a P450 panel on > > everyone before they take abx- so we'll know which ones will be > > detrimental to us BEFORE we take them. > > Right now it's a crap shoot- and everyone must decide the risks for > > themselves. I've taken plenty - but am vigilant when I do so > > hopefully stop something before it's too late. > > > > Not everyone's body metabolizes the same. > > > > P450 profiles would be a great thing. I know they can do it now, > but > > it's not a wide spread practice. > > > > ALL ANTIBIOTICS have a side effect. You have to weigh them all. > > > > Barb > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 2, 2007 Report Share Posted January 2, 2007 Speaking of quinolones and adverse effects, how does a torn tendon on the top of the foot look and feel like? I've been taking Levaquin for about 3-4 weeks via IV and I noticed today the top of my foot is swollen. It has been hurting somewhat, and I attributed it to arthritis pains. It's right where the toes meet the top of the foot. Bp Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 2, 2007 Report Share Posted January 2, 2007 Bp Your docs treating your bone infection with levaquin? Tony --- In infections , " BP " <zaafira@...> wrote: > > Speaking of quinolones and adverse effects, how does a torn tendon on the > top of the foot look and feel like? I've been taking Levaquin for about 3-4 > weeks via IV and I noticed today the top of my foot is swollen. It has been > hurting somewhat, and I attributed it to arthritis pains. It's right where > the toes meet the top of the foot. > > Bp > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 2, 2007 Report Share Posted January 2, 2007 Yes, as I mentioned in my previous email, I'm taking Levaquin for a bone infection. I was on Vancomycin and Fortaz, but had allergic reactions to those. :-( So, I was wondering: Speaking of quinolones and adverse effects, how does a torn tendon on the > top of the foot look and feel like? I've been taking Levaquin for about 3-4 > weeks via IV and I noticed today the top of my foot is swollen. It has been > hurting somewhat, and I attributed it to arthritis pains. It's right where > the toes meet the top of the foot. > > Bp Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 3, 2007 Report Share Posted January 3, 2007 Is fortaz also known as meripenam(spelling)...I'm not sure I got the name right it's in the Imepenam class of drugs? tony --- In infections , " BP " <zaafira@...> wrote: > > Yes, as I mentioned in my previous email, I'm taking Levaquin for a bone > infection. I was on Vancomycin and Fortaz, but had allergic reactions to > those. :-( > > So, I was wondering: Speaking of quinolones and adverse effects, how does a > torn tendon > on the > > top of the foot look and feel like? I've been taking Levaquin for > about 3-4 > > weeks via IV and I noticed today the top of my foot is swollen. It > has been > > hurting somewhat, and I attributed it to arthritis pains. It's > right where > > the toes meet the top of the foot. > > > > Bp > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 5, 2007 Report Share Posted January 5, 2007 Why levaquin for bone infection? This seems very strange. Based on cultures? pennyBP <zaafira@...> wrote: Yes, as I mentioned in my previous email, I'm taking Levaquin for a bone infection. I was on Vancomycin and Fortaz, but had allergic reactions to those. :-( So, I was wondering: Speaking of quinolones and adverse effects, how does a torn tendonon the> top of the foot look and feel like? I've been taking Levaquin forabout 3-4> weeks via IV and I noticed today the top of my foot is swollen. Ithas been> hurting somewhat, and I attributed it to arthritis pains. It'sright where> the toes meet the top of the foot.>> Bp Quote Link to comment Share on other sites More sharing options...
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