doxycline long term; what about developing resistency issues; Re: Anaphylactic shock, etc

May 14, 2006

Tony: My question has to do with any

concerns I should have about becoming resistant to doxy as well if taken long

term as it is one of the few classes that I am still susceptible to (re MRSA).

My peak flows are back up above yellow zone and I’m breathing much

better. Albubuterol nebulizer now 4x per day.

My RX for the moment for doxycline is for

10 days and was started Friday. I am also using bactroban ointment in my

nostrils because that is what I have on hand. I see the PCP who put me on it

tomorrow am again to f/u from Friday and Wed’s visits. I can get an antifungal

but she won’t be ‘in the mood” to prescribe long term but I

will ask/persuade her at least for one refill. I see my natural minded neuro

the following day Tuesday and he was already talking about putting me on long

term antibiotcs. When I saw him last month, I didn’t know I’d be

able to tolerate the doxy but I am. But then my gut is in much better shape

than it was the last time doxy was tried a year ago and dx due to immediate and

severe diarrhea. At the time we were discussing IV antibx which would mean

putting in another central line catheter which I want to avoid (they keep

getting too infected) but my plan is to have him keep me on the doxy longer as

well as the anti-fungal as long as I continue to tolerate.

In seeing the discussions on liver

function, I already have well elevated liver enzymes past years and now for no

apparent reason. I assume part of flaws in my detox pathways………..

From: infections [mailto:infections ] On Behalf Of dumbaussie2000

Sent: Sunday, May 14, 2006 6:02 PM

infections

Subject:

[infections] Re: Anaphylactic shock, Electrolytes, Salt/C,

Ampehotericine B, Benicar etc.

Don't back off the doxy if it is really having a major impact. Try

add a antifungal since most abx don't agree, I believe you'll have

less problems with all drugs when your pathogens are being

quietened.There's nothing dangerous about doing doxy for a year.

tony

>

> I have had anaphylactic reactions to penicillin

> and sulfa since I was a teen (both requiring tubes

> down my throat due to reaction) . In recent years

> , I began reacting to many more meds and later

> supps and having allergic reactions of severe

> asthma, severe hives, short of breath and in some

> cases " just " severe diarrhea or medication induced

> anorexia.

>

> My electrolyte studies last month and even my hair

> test show that I am very low in both potassium and

> magnesium and yet I was supplementing both and

> still do and eat foods very high in both.

> Something isn't working right. Some changes made

> in the past few weeks under direction of my

> natural minded neuro and natural minded ENT

> working together were first to try mag sulfate

> injections which worsened symptoms dramatically

> and now am supplementing potassium as well as

> taking magnesium malate tablets and transdermal

> mag citrate. My walking and EDSS numbers have

> improved dramatically in the past 10 days (score

> used to define degree of disability related to MS)

> after continued progression since 2003 and being

> in and out of a wheelchair or walker since 2004.

> They are also tinkering to get my thyroid under

> control. Been on synthroid for 13 years but still

> not testing right and am currently on both levoxyl

> and armour and see Neuro Tues to continue his plan

> to either migrate to armour entirely or some combo

> of both. He believes my thyroid issues started all

> my health problems.

>

> My asthma and breathing issues are improving

> dramatically since starting doxycline and

> administration of bactroban in my nostrils (gave

> up on the idea of putting the bactroban in my

> nebulizer) and doing albuterol treatments every 4

> hour around the clock. My ENT had previously had

> me using bactroban nasal irrigation but I was

> swallowing and choking on the stuff and PCP thinks

> may have aspirated some causing my initial

> breathing problems. I am very interested in what

> I've read about the Welden protocol although my

> MRSA is resistant to some of the things suggested

> in the protocol. I will discuss with my PCP, ENT,

> and Neuro (all of whom I see next week) regarding

> staying longer on the antibiotic and/or adding

> another and adding antifungal. Also waiting for

> results of sputum analysis from Friday (although

> we know how those go but they were going to use

> the infectious disease lab to analyze)..

>

> Thanks for the reminder re liver issues as I like

> some others have elevated liver enzymes and amino

> acid test and organic acid test done in last 3

> weeks reflects the same issues. Waiting to discuss

> results with my docs but I have copies and have

> reviewed both reports and understand the

> implications.

>

> _____

>

> From: infections

> [mailto:infections ]

> On Behalf Of Colourbleu

> Sent: Sunday, May 14, 2006 4:51 AM

> infections

> Subject: [infections] Anaphylactic

> shock, Electrolytes, Salt/C, Ampehotericine B,

> Benicar etc.

>

> Anaphylactic shock, Electrolytes, Salt/C,

> Ampehotericine B, Benicar etc.

>

> got me thinking, as she has been having so

> many problems with

> anaphylactic shock reactions and breathing crises.

> Im wondering what is

> going on?

>

> I have personally had what I think were

> anaphylactic shocks (2), after

> administering b12 shots. This is a rare possible

> side effect of B12

> shots. This is one frightening symptom.

>

> I came to the conclusion that actually what caused

> this was a low blood

> potassium level. I could not handle the shots and

> continued with b12

> tablets and added potassium. This seemed to help

> allot.

>

> The bodies electrolyte system works on a fine

> balance and when out of

> sync the symptoms can be sudden and drastic. Many

> of the drugs that we

> take, work by robing the body of potassium in one

> way or another. Or by

> another mechanism disrupting the electrolyte

> system.

>

> Many of us that are close to the edge and have

> seriously hampered

> bodies which can be tilted over the edge very

> easily when taking these

> drugs.

>

> It does not make 100% sense that is allergic

> to lots of different

> drugs and I suspect that maybe another problem is

> lurking in the

> background (potassium loss?) that is the

> underlying problem.

>

> It would seem that this problem (if there) and

> discovered would open

> the flood gates for treatments that seem to be so

> badly needed (abx/

> a/f).

>

> If I were you I think I would consider

> having a basic electrolyte

> test, and keeping an eye on these in the future.

> These electrolytes can

> cause havoc if out of whack and make us very ill

> very quickly. Hence

> the administration of electrolytes when you go

> into emergency in

> hospital (very often).

>

> Penny as your on Benicar and had problems with the

> kidneys in the past,

> I think you should be especially careful when

> taking amp b, and over

> time watch your electrolytes as I think the oral

> form does enter the

> system and does rob the body of potassium.

>

> Salt / C

> I have spoken to some of the main advocates of the

> salt/c treatment,

> and while clearly it has benefits, they seemed

> totally ignorant of the

> possible of side effects from taking too much salt

> thus lowering the

> potassium levels. If anyone is doing the Salt/C I

> would also suggest

> potassium is monitored and possible added into the

> regime too.

>

> If anyone comes over very iffy, very quickly, the

> electrolytes should

> be considered as a potential cause of this sudden

> attack.

>

> Bleu

>

May 15, 2006

This ignores the fact that I must find one

of my docs to continue me on the drug. Doxycline isn’t OTC here but I

understand what you are saying. The antifungal I can do tomorrow….The

antibiotic ; goal is getting her to refill cause want to be sure we are rid of infection

i.e. get me to 28 days and then get more refills from neuro or ent I see in

following days.

I don’t understand the answer to the

question re resistency: about becoming resistant to doxy as

> well if taken long term since for the moment it and vancomycin are all

that show susceptible on my mrsa culture.

From: infections [mailto:infections ] On Behalf Of dumbaussie2000

Sent: Sunday, May 14, 2006 7:22 PM

infections

Subject:

[infections] doxycline long term; what about developing

resistency issues; Re: Anaphylactic shock, etc

You want to keep the doxy going and add a couple of other agents-

antifungals? The idea that you can keep using the drug everytime you

get floored is silly cause you lost resistance to another 12

antimicrobials in a flash why you'd want your next antibiotioc

challenge to be more difficult is beyond commonsense. bascially it

just doesn't work that way.PLUS the big PLus in your case is your

heading towards total inability and all the positive treatments in a

row are the order of the day.

I also had elevated liver readings when on nothing and actually was

within range when feeling good.Toxins are obviously a huge part of

this problem not some unimagenable wippy doo thing your docs pull

out there rare.

tony

> >

> > I have had anaphylactic reactions to penicillin

> > and sulfa since I was a teen (both requiring

> tubes

> > down my throat due to reaction) . In recent

> years

> > , I began reacting to many more meds and later

> > supps and having allergic reactions of severe

> > asthma, severe hives, short of breath and in

> some

> > cases " just " severe diarrhea or medication

> induced

> > anorexia.

> >

> > My electrolyte studies last month and even my

> hair

> > test show that I am very low in both potassium

> and

> > magnesium and yet I was supplementing both and

> > still do and eat foods very high in both.

> > Something isn't working right. Some changes made

> > in the past few weeks under direction of my

> > natural minded neuro and natural minded ENT

> > working together were first to try mag sulfate

> > injections which worsened symptoms dramatically

> > and now am supplementing potassium as well as

> > taking magnesium malate tablets and transdermal

> > mag citrate. My walking and EDSS numbers have

> > improved dramatically in the past 10 days (score

> > used to define degree of disability related to

> MS)

> > after continued progression since 2003 and being

> > in and out of a wheelchair or walker since 2004.

> > They are also tinkering to get my thyroid under

> > control. Been on synthroid for 13 years but

> still

> > not testing right and am currently on both

> levoxyl

> > and armour and see Neuro Tues to continue his

> plan

> > to either migrate to armour entirely or some

> combo

> > of both. He believes my thyroid issues started

> all

> > my health problems.

> >

> > My asthma and breathing issues are improving

> > dramatically since starting doxycline and

> > administration of bactroban in my nostrils (gave

> > up on the idea of putting the bactroban in my

> > nebulizer) and doing albuterol treatments every

> 4

> > hour around the clock. My ENT had previously had

> > me using bactroban nasal irrigation but I was

> > swallowing and choking on the stuff and PCP

> thinks

> > may have aspirated some causing my initial

> > breathing problems. I am very interested in what

> > I've read about the Welden protocol although my

> > MRSA is resistant to some of the things

> suggested

> > in the protocol. I will discuss with my PCP,

> ENT,

> > and Neuro (all of whom I see next week)

> regarding

> > staying longer on the antibiotic and/or adding

> > another and adding antifungal. Also waiting for

> > results of sputum analysis from Friday (although

> > we know how those go but they were going to use

> > the infectious disease lab to analyze)..

> >

> > Thanks for the reminder re liver issues as I

> like

> > some others have elevated liver enzymes and

> amino

> > acid test and organic acid test done in last 3

> > weeks reflects the same issues. Waiting to

> discuss

> > results with my docs but I have copies and have

> > reviewed both reports and understand the

> > implications.

> >

> > _____

> >

> > From: infections

> >

> [mailto:infections ]

> > On Behalf Of Colourbleu

> > Sent: Sunday, May 14, 2006 4:51 AM

> > infections

> > Subject: [infections]

> Anaphylactic

> > shock, Electrolytes, Salt/C, Ampehotericine B,

> > Benicar etc.

> >

> > Anaphylactic shock, Electrolytes, Salt/C,

> > Ampehotericine B, Benicar etc.

> >

> > got me thinking, as she has been having so

> > many problems with

> > anaphylactic shock reactions and breathing

> crises.

> > Im wondering what is

> > going on?

> >

> > I have personally had what I think were

> > anaphylactic shocks (2), after

> > administering b12 shots. This is a rare possible

> > side effect of B12

> > shots. This is one frightening symptom.

> >

> > I came to the conclusion that actually what

> caused

> > this was a low blood

> > potassium level. I could not handle the shots

> and

> > continued with b12

> > tablets and added potassium. This seemed to help

> > allot.

> >

> > The bodies electrolyte system works on a fine

> > balance and when out of

> > sync the symptoms can be sudden and drastic.

> Many

> > of the drugs that we

> > take, work by robing the body of potassium in

> one

> > way or another. Or by

> > another mechanism disrupting the electrolyte

> > system.

> >

> > Many of us that are close to the edge and have

> > seriously hampered

> > bodies which can be tilted over the edge very

> > easily when taking these

> > drugs.

> >

> > It does not make 100% sense that is

> allergic

> > to lots of different

> > drugs and I suspect that maybe another problem

> is

> > lurking in the

> > background (potassium loss?) that is the

> > underlying problem.

> >

> > It would seem that this problem (if there) and

> > discovered would open

> > the flood gates for treatments that seem to be

> so

> > badly needed (abx/

> > a/f).

> >

> > If I were you I think I would consider

> > having a basic electrolyte

> > test, and keeping an eye on these in the future.

> > These electrolytes can

> > cause havoc if out of whack and make us very ill

> > very quickly. Hence

> > the administration of electrolytes when you go

> > into emergency in

> > hospital (very often).

> >

> > Penny as your on Benicar and had problems with

> the

> > kidneys in the past,

> > I think you should be especially careful when

> > taking amp b, and over

> > time watch your electrolytes as I think the oral

> > form does enter the

> > system and does rob the body of potassium.

> >

> > Salt / C

> > I have spoken to some of the main advocates of

> the

> > salt/c treatment,

> > and while clearly it has benefits, they seemed

> > totally ignorant of the

> > possible of side effects from taking too much

> salt

> > thus lowering the

> > potassium levels. If anyone is doing the Salt/C

> I

> > would also suggest

> > potassium is monitored and possible added into

> the

> > regime too.

> >

> > If anyone comes over very iffy, very quickly,

> the

> > electrolytes should

> > be considered as a potential cause of this

> sudden

> > attack.

> >

> > Bleu

> >

May 15, 2006

, You might want to check the P450 pathway charts in the links section at the home page. Make sure you don't inadvertently combine any drugs that could add to your liver woes. pennyjulie levitt <knightshotter@...> wrote: Tony: My question has to do with any concerns I should have about becoming resistant to doxy as well if taken long term as it is one of the few classes that I am still susceptible to (re MRSA). My peak flows are back up above yellow zone and I’m breathing much better. Albubuterol nebulizer now 4x per day. My RX for the moment for doxycline is for 10 days and was started Friday. I am also using bactroban ointment in my nostrils because that is what I have on hand. I see the PCP who put me on it tomorrow am again to f/u from Friday and Wed’s visits. I can get an antifungal but she won’t be ‘in the mood” to prescribe long term but I will ask/persuade her at least for one refill. I see my natural minded neuro the following day Tuesday and he was already talking about putting me on long term antibiotcs. When I saw him last month, I didn’t know I’d be able to tolerate the doxy but I am. But then my gut is in much better shape than it was the last time doxy was tried a year ago and dx due to immediate and severe diarrhea. At the time we were discussing IV antibx which would mean putting in another central line catheter which I want to avoid (they keep getting too infected) but my plan is to have him

keep me on the doxy longer as well as the anti-fungal as long as I continue to tolerate. In seeing the discussions on liver function, I already have well elevated liver enzymes past years and now for no apparent reason. I assume part of flaws in my detox pathways……….. From: infections [mailto:infections ] On Behalf Of dumbaussie2000Sent: Sunday, May 14, 2006 6:02 PMinfections Subject: [infections] Re: Anaphylactic shock, Electrolytes, Salt/C, Ampehotericine B, Benicar etc. Don't back off the doxy if it is really having a major impact. Try add a antifungal since most abx don't agree, I believe you'll have less problems with all drugs when your pathogens are being quietened.There's nothing dangerous about doing doxy for a year.tony>> I have had anaphylactic reactions to penicillin> and sulfa since I was a teen (both requiring tubes> down my throat due to reaction) . In recent years> , I began reacting to many more meds and later> supps and having allergic reactions of severe> asthma, severe hives, short of breath and in some> cases "just" severe diarrhea or medication induced> anorexia.> > >

> My electrolyte studies last month and even my hair> test show that I am very low in both potassium and> magnesium and yet I was supplementing both and> still do and eat foods very high in both.> Something isn't working right. Some changes made> in the past few weeks under direction of my> natural minded neuro and natural minded ENT> working together were first to try mag sulfate> injections which worsened symptoms dramatically> and now am supplementing potassium as well as> taking magnesium malate tablets and transdermal> mag citrate. My walking and EDSS numbers have> improved dramatically in the past 10 days (score> used to define degree of disability related to MS)> after continued progression since 2003 and being> in and out of a wheelchair or walker since 2004.> They are also tinkering to get my thyroid under> control. Been on synthroid for 13

years but still> not testing right and am currently on both levoxyl> and armour and see Neuro Tues to continue his plan> to either migrate to armour entirely or some combo> of both. He believes my thyroid issues started all> my health problems. > > > > My asthma and breathing issues are improving> dramatically since starting doxycline and> administration of bactroban in my nostrils (gave> up on the idea of putting the bactroban in my> nebulizer) and doing albuterol treatments every 4> hour around the clock. My ENT had previously had> me using bactroban nasal irrigation but I was> swallowing and choking on the stuff and PCP thinks> may have aspirated some causing my initial> breathing problems. I am very interested in what> I've read about the Welden protocol although my> MRSA is resistant to some of the things suggested>

in the protocol. I will discuss with my PCP, ENT,> and Neuro (all of whom I see next week) regarding> staying longer on the antibiotic and/or adding> another and adding antifungal. Also waiting for> results of sputum analysis from Friday (although> we know how those go but they were going to use> the infectious disease lab to analyze)..> > > > Thanks for the reminder re liver issues as I like> some others have elevated liver enzymes and amino> acid test and organic acid test done in last 3> weeks reflects the same issues. Waiting to discuss> results with my docs but I have copies and have> reviewed both reports and understand the> implications.> > > > _____ > > From: infections > [mailto:infections ]> On Behalf Of Colourbleu> Sent: Sunday, May 14, 2006 4:51 AM> infections > Subject: [infections] Anaphylactic> shock, Electrolytes, Salt/C, Ampehotericine B,> Benicar etc.> > > > Anaphylactic shock, Electrolytes, Salt/C,> Ampehotericine B, Benicar etc.> > got me thinking, as she has been having so> many problems with > anaphylactic shock reactions and breathing crises.> Im wondering what is > going on?> > I have personally had what I think were> anaphylactic shocks (2), after > administering b12 shots. This is a rare possible> side effect of B12 > shots. This is one frightening symptom.> > I came to the conclusion that actually

what caused> this was a low blood > potassium level. I could not handle the shots and> continued with b12 > tablets and added potassium. This seemed to help> allot.> > The bodies electrolyte system works on a fine> balance and when out of > sync the symptoms can be sudden and drastic. Many> of the drugs that we > take, work by robing the body of potassium in one> way or another. Or by > another mechanism disrupting the electrolyte> system.> > Many of us that are close to the edge and have> seriously hampered > bodies which can be tilted over the edge very> easily when taking these > drugs.> > It does not make 100% sense that is allergic> to lots of different > drugs and I suspect that maybe another problem is> lurking in the > background (potassium loss?) that is the> underlying

problem.> > It would seem that this problem (if there) and> discovered would open > the flood gates for treatments that seem to be so> badly needed (abx/ > a/f).> > If I were you I think I would consider> having a basic electrolyte > test, and keeping an eye on these in the future.> These electrolytes can > cause havoc if out of whack and make us very ill> very quickly. Hence > the administration of electrolytes when you go> into emergency in > hospital (very often).> > Penny as your on Benicar and had problems with the> kidneys in the past, > I think you should be especially careful when> taking amp b, and over > time watch your electrolytes as I think the oral> form does enter the > system and does rob the body of potassium.> > Salt / C> I have spoken to some of the main

advocates of the> salt/c treatment, > and while clearly it has benefits, they seemed> totally ignorant of the > possible of side effects from taking too much salt> thus lowering the > potassium levels. If anyone is doing the Salt/C I> would also suggest > potassium is monitored and possible added into the> regime too.> > If anyone comes over very iffy, very quickly, the> electrolytes should > be considered as a potential cause of this sudden> attack.> > Bleu> > > > > > > > > > > > > > > >

May 15, 2006

I have reviewed the P450 pathway chart

before and don’t take any of these that I can tell. Some other links on

this topic are here:

P450 phytochrome 450

http://www.anaesthetist.com/physiol/basics/metabol/cyp/cyp.htm

Here's a table of drugs that interact with

the P450 in ways that are outside

" normal " and if the tests are

indicating this is an area to explore based on

the organic acid results, it may help you

detox better if you know what can

be affecting you adversely...although this

is getting a bit out of my

league, Great Plains

does give a consult (free) with the testing, so finding

out if there are indications of a genetic

condition that affects drug

metabolism might be really important to

letting your system operate more

efficiently by removing or substituting

the pharmaceuticals that can be

stressing you:

http://medicine.iupui.edu/flockhart/table.htm

From:

infections

[mailto:infections ] On Behalf Of Penny Houle

Sent: Sunday, May 14, 2006 11:58

PM

infections

Subject: RE:

[infections] doxycline long term; what about developing

resistency issues; Re: Anaphylactic shock, etc

,

You might want to check the P450 pathway charts in the links section at

the home page. Make sure you don't inadvertently combine any drugs that could

add to your liver woes.

penny

julie levitt

<knightshotter@...> wrote: