Re: how do bacteria become resistant to certain antibiotics?

[Guest guest]

Your doctor prescribes a specific drug for you based on what kind of infection you have. He or she also selects a specific dose and length for your treatment. The old antibiotic you have may not work at all against the infection you have, so it's best to seek a doctor's advice before trying to treat yourself. LOL! This is hilarious. Like the docs have any real basis for treatment or duration other than what the drug companies tell them. Unless it's an i.d. doc or someone treating based on cultures and sensitivities, I wouldn't trust them at all. It's their complete lack of identifying organisms and resistances, then treating generically, and often undertreating, that's causing this problem in the first place. penny

[Guest guest]

Cool so what is the answer?? how do

bacteria become resistant to certain antibiotics?

From:

infections

[mailto:infections ] On Behalf Of Penny Houle

Sent: Monday, May 15, 2006 6:15 PM

To:

infections

Subject: Re: [infections]

how do bacteria become resistant to certain antibiotics?

Your doctor prescribes a specific drug for you based on

what kind of infection you have. He or she also selects a specific dose and

length for your treatment. The old antibiotic you have may not work at all

against the infection you have, so it's best to seek a doctor's advice before

trying to treat yourself.

LOL! This is hilarious. Like the docs have any real basis for treatment

or duration other than what the drug companies tell them. Unless it's an i.d.

doc or someone treating based on cultures and sensitivities, I wouldn't

trust them at all. It's their complete lack of identifying organisms and

resistances, then treating generically, and often undertreating, that's causing

this problem in the first place.

penny

[Guest guest]

I thikn the question is how do bacteria NOT become resistant. Doc's misuse of abx certainly doesn't help. i'm sorry, but I'm too tired right now to go into all the ways bacteria outwit abx. But you can do some searches and find many many answers. Almost poetic...how do I count the ways... I thought your article was good other than the part about patients misusing abx and docs treating correctly. It's a joke because it's the docs who are creating the problem by not testing our organisms in the first place and treating us with guess work. Then they lecture US for "misusing" antibiotics. I so wish I could be treated by a vet. Hey, I wish I were married to a vet! Some people want to marry rich, but I'd rather marry a vet, or a sympathetic lab tech. We should be on the look out for matchmaking sites designed specifically for

vets. lol! pennyjulie levitt <knightshotter@...> wrote: Cool so what is the answer?? how do bacteria become resistant to certain antibiotics? From: infections [mailto:infections ] On Behalf Of Penny HouleSent: Monday, May 15, 2006 6:15 PMinfections Subject: Re: [infections] how do bacteria become resistant to certain antibiotics? Your doctor prescribes a specific drug for you based on what kind of infection you have. He or she also selects a specific dose and length for your treatment. The old antibiotic you have may not work at all against the infection you have, so it's best to seek a doctor's advice before trying to treat yourself. LOL! This is hilarious. Like the docs have any real basis for treatment or duration other than what the drug companies tell them. Unless it's an i.d. doc or someone treating based on cultures and sensitivities, I wouldn't trust them at all. It's their complete lack of identifying organisms and resistances, then treating generically, and often undertreating, that's causing this problem in the first place. penny

[Guest guest]

> Cool so what is the answer?? how do bacteria

> become resistant to certain antibiotics?

>

The fundemental distinction is between genomic (genetic) and

phenotypic resistence.

Phenotypic resistence comes from an unusual physical state of the

bacterium, such as very slow growth. It is not too well understood.

In my opinion phenotypic resistence is probably the main problem in

CFS (my situation) and other diseases where bacterial infection seems

likely to figure. I dont have strong proof of this; its an opinion

about what seems most plausible to me.

In phenotypic resistence there is nothing genetic going on that

causes the resistence.

Genomic resistence, in contrast, comes from genetic mutation. DNA

(the genes) code for proteins, so a mutation (change) in DNA lets a

bacterium make a different variant of a normal protein, or a totally

new kind of protein. And proteins, in turn, carry out almost all of

the action in biology. Via antibiotic resistence proteins, genetic

mutations can:

- break down or change the antibiotic molecule so it is inactivated

- expell the antibiotic molecule from the cell

- permit 'detour' biochemical pathways to be used when a normal

biochemical pathway is blocked by an antibiotic

- prevent the binding of an antibiotic that works by binding to and

inactivating the normal protein

I feel like I'm forgetting one of the major ones. And there are

several minor ones.