Cimetidine Update

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Hello, well, after 7 days of cimetidine 400mg 2 x daily I can report that the results have been quite spectacular. First thing to report is that the effect of the drug was immediate . I awoke the second day with my eyes gummed shut, same third & fourth day then diminishing , I see that it is probably addressing an allergic reaction that the bugs hide behind [below] The fact that the effect was immediate indicates that it is a direct action not indirect through bacteria ..So for my money the drug re-sets the immune system, initially anyway.the histamine being the catalyst that can push the IS into an allergy type TH2 response . With the effects of cimetidine I have been able to stop taking antibiotics , well almost I took one 250mg Lamisil this morning ..the effect of cimetine is the same as when infected with an additional virus or similar. The IS is without doubt stimulated ..The question now is would I benefit from small doses of Abx's what exactly is the best protocol to go with this new found wonder drug?? Absorbsion is a problem , especially with tetracyclines [below] So there it is, one week of discovery , in short, so far, the drug is living up to the medline reports, its reputation as an immune booster is well deserved . The situation does pose a few questions, like how does the stealth aspect fit into this?

There are many pathogens that are intracellular , the immune system gets them in the end [well most] with luck , this drug could give the IS the edge over these stealth tactics..Curr Opin Allergy Clin Immunol. 2005 Oct;5(5):437-40. Related Articles, Links Histamine receptors and the conjunctiva.Bielory L, Ghafoor S.UMDNJ, New Jersey Medical School, Newark, New Jersey 07103, USA. bielory@...PURPOSE OF REVIEW: The purpose of this review is to evaluate the effect of histamine on various receptors in the conjunctiva. A Medline search from 1980 was performed on the histamine receptor subtypes H1, H2 and H3 in the human conjunctiva. RECENT FINDINGS: In the conjunctiva, histamine has been shown to induce various physiological and immunological changes through both H1 and H2 receptor stimulation. Histamine binding to conjunctival H1 receptors through the phospholipase C-dependent inositol phosphate pathway leads to the symptom of pruritus while histamine stimulation of the conjunctival H2 receptors has been indirectly shown to cause vasodilation. SUMMARY: The effect of histamine on conjunctival H1 receptors appears to be the primary target for ocular allergy treatment as it is primarily involved in ocular pruritus. The exact interaction of the conjunctival H2 receptors appears to work in a complementary fashion to the H1 receptor in controlling other features of ocular allergy such as vasodilation and injection. Thus, oral and topical antihistamines with multiple histamine receptor binding activities may provide an improved treatment paradigm for the various signs and symptoms of ocular allergy. The histamine H1, H2 and H3 receptor affinities of ketotifen, pyrilamine, and epinastine appear to have the strongest H1 and H2 affinities.Publication Types:· ReviewPMID: 16131920 [PubMed - indexed for MEDLINE]Cell Mol Biol (Noisy-le-grand). 1994 May;40(3):275-81. Related Articles, LinksPharmacological properties of histamine receptor subtypes.Arrang JM.Unite de Neurobiologie et Pharmacologie, U.109 de l'INSERM, Centre Broca, Paris, France.Histamine, a ubiquitous cell-to-cell messenger, exerts its numerous actions through interaction with three pharmacologically distinct receptor subtypes, termed H1, H2 and H3. The design of selective agonists and antagonists has allowed to establish their respective pharmacological profile. Radioligand binding studies and, very recently, molecular biological studies have shown that they all belong to the superfamily of G-protein coupled receptors. H1 and H2-receptor antagonists have been successfully used for a long time in the treatment of allergy and ulcer, respectively. Some of them have been designed as highly potent and selective radioligands and have allowed to analyze the precise distribution of H1 and H2 receptors in various tissues including the brain. Recently, H1- and H2-receptor genes have been cloned in various animal species. Transfection of mammalian cells with these intronless genes has confirmed the respective coupling of H1 and H2 receptors with phospholipase C and adenylylcyclase. However, other known or unknown intracellular signals, could also be triggered by the stimulation in a transfected cell of a single H1 or H2 receptor through coupling to different G-proteins. A third histamine receptor subtype, the H3 receptor was evidenced in rodent and human brain by the inhibition of histamine release and synthesis it mediates in various areas. Thus, H3 receptors were considered as autoreceptors localized on histaminergic terminals. With the design of several potent and selective H3-receptor agonists and of an antagonist thioperamide, the critical role of H3 receptors in the control of histaminergic neurons in vivo was established.(ABSTRACT TRUNCATED AT 250 WORDS)Publication Types:· ReviewPMID: 7920174 [PubMed - indexed for MEDLINE]Pak J Pharm Sci. 2005 Apr;18(2):55-60. Related Articles, LinksIn vitro release of tetracyclines in presence of H2-receptor antagonists.Iftikhar A, Arayne MS, Sultana N.Faculty of Pharmacy, Hamdard University, Karachi.There are a number of drug interactions reported for tetracyclines with many other drugs. In present study in vitro release of five different tetracyclines i.e., tetracycline, demeclocycline, oxytetracycline, methacycline and doxycycline in presence of cimetidine and ranitidine has been studied by USP XX dissolution method. The release of almost all tetracyclines was depressed in presence of cimetidine and ranitidine while in some cases the value were greatly increased due to the formation of charge transfer complexes of the antibiotic with H2-receptor antagonists, which gave absorbance at same wavelengths but with much higher molar absorptivity. An attempt was made to elucidate the mechanism of this effect.PMID: 16431401 [PubMed - indexed for MEDLINE]Gan To Kagaku Ryoho. 2005 Oct;32(11):1576-7. Related Articles, Links [The effect of cimetidine mainly increases CD4+ cells of peripheral blood T lymphocytes][Article in Japanese]Asakage M, Tsuno NH, Kitayama J, Yamada J, Tsuchiya T, Yoneyama S, Takahashi K, Nagawa H.Dept of Surgical Oncology, University of Tokyo.Cimetidine, one of the most popular histamine-2 receptor antagonists, has been reported to improve survival in gastrointestinal cancer patients and to activate cell-mediated immune response in surgical patients. NKT cells are a population of T cells that share characteristics with natural killer cells, and their main functions are production of immunoregulatory cytokines and cytolytic activities. In this study, we aimed to investigate the effect of cimetidine on the cell-mediated immunoresponse. Six healthy adult volunteers were given 800 mg of cimetidine per day orally, and their blood samples were taken prior to and at days 1, 3, 5, and 7 days post-administration of cimetidine. Leukocyte counts and differentials were obtained by the conventional hemogram, and the leukocyte subsets were analyzed by flow cytometry. Cimetidine administration caused leukocytosis, dependent on the increase of neutrophils, as well as of the CD3-positive T lymphocytes, and the subset of CD4-positive cells among them. On the other hand, the NK cell subpopulation was decreased, and the NKT cell subpopulation was not affected. The present results suggest that cimetidine is a modulator of the cellular immunity, and may be used as the activator of the tumor specific immunoresponse.PMID: 16315874 [PubMed - indexed for MEDLINE]