Re: Ceftriaxone therapy of chronic inflammatory arthritis. A double-blind placebo co

[Guest guest]

I was in hospital last year, and was given IV ceftin.

It helped quit a bit. So I started to take 250mg

twice daily, and it seems my arthritis is retreating.

I do that for 10 days then switch to cipro for 10

days. The cipro does not help near as much, it seems

my ostiomylitis has gotten used to the cipro.

--- <usenethod@...> wrote:

> Arch Intern Med. 1990 Aug;150(8):1677-82. Related

> Articles, Links

>

>

> Ceftriaxone therapy of chronic inflammatory

> arthritis. A double-

> blind placebo controlled trial.

>

> Caperton EM, Heim-Duthoy KL, Matzke GR, PK,

> RC.

>

> Arthritis Associates of Minnesota, P.A., Minneapolis

> 55404.

>

> To determine whether chronic inflammatory arthritis

> may respond to

> antibiotic therapy (implying a bacterial origin), we

> conducted a

> placebo-controlled, double-blind study. Sixty

> patients with

> inflammatory arthritis and antibody titers to

> Borrelia burgdorferi

> 1:64 or more were randomized to receive placebo (n =

> 20) or 2 g/d of

> ceftriaxone intravenously (n = 40) for 2 weeks. Two

> of 20 placebo-

> and 19 of 40 antibiotic-treated patients improved.

> At 1 month, the

> placebo-treated patients could elect to receive

> ceftriaxone.

> Altogether, 58 patients were treated with

> ceftriaxone and followed

> up for 13 to 24 months. Improvement was noted in 27

> of the 58

> antibiotic-treated patients. Patients with a wide

> diversity of

> inflammatory arthritis were studied. Response to

> ceftriaxone was

> seen in all groups, including 5 of 12 with

> rheumatoid arthritis, 5

> of 8 with psoriatic arthritis, 3 of 5 with

> vasculitis, and 14 of 33

> with less well-differentiated chronic inflammatory

> arthritis. In 16

> of the 27 who responded to the antibiotic, the

> arthritis worsened 6

> to 18 months after the initial response to

> ceftriaxone. Previous

> improvement of arthritis after oral antibiotic was a

> better

> predictor of response to ceftriaxone than either

> duration of disease

> or Lyme antibody titer. Side effects to ceftriaxone

> were frequent

> and included diarrhea (29/60) and acute allergic

> reactions (9/58).

> We conclude that some patients may have an occult

> bacterial

> infection underlying their chronic inflammatory

> arthritis, and may

> respond to antibiotic therapy. The response to

> ceftriaxone in

> patients with even weakly reactive Lyme titers

> encourages further

> prospective placebo-controlled studies of

> antibiotics in various

> subsets of chronic arthritis.

>

> Publication Types:

> Clinical Trial

> Randomized Controlled Trial

>

> PMID: 2383162 [PubMed - indexed for MEDLINE]

>

>

>

>

>

__________________________________________________

[Guest guest]

Wow. For once they actually conclude that the abx might work against

arthritis because of an underlying infection, not because of some

miraculous byproduct of the abx!!! I like these Minnesota guys.

I responded well to ceftin for 2 to 3 months. Then it lost it's

effectiveness, or I should say the bugs got stronger. Maybe I'll try

it again, see what happens, since my pencillin VK combo seems to be

turning now as well.

penny

" " <usenethod@...> wrote:

>

> Arch Intern Med. 1990 Aug;150(8):1677-82. Related Articles, Links

>

>

> Ceftriaxone therapy of chronic inflammatory arthritis. A double-

> blind placebo controlled trial.

>

> Caperton EM, Heim-Duthoy KL, Matzke GR, PK, RC.

>

> Arthritis Associates of Minnesota, P.A., Minneapolis 55404.

>

>

> We conclude that some patients may have an occult bacterial

> infection underlying their chronic inflammatory arthritis, and may

> respond to antibiotic therapy. The response to ceftriaxone in

> patients with even weakly reactive Lyme titers encourages further

> prospective placebo-controlled studies of antibiotics in various

> subsets of chronic arthritis.

>

> Publication Types:

> Clinical Trial

> Randomized Controlled Trial

>

> PMID: 2383162 [PubMed - indexed for MEDLINE]

>

[Guest guest]

That 'stract is a relic of another age...

> Wow. For once they actually conclude that the abx might work against

> arthritis because of an underlying infection, not because of some

> miraculous byproduct of the abx!!! I like these Minnesota guys.

>