Guest guest Posted January 30, 2006 Report Share Posted January 30, 2006 > > http://gasp.med.harvard.edu/micro200/Rubin/TB%20persistence% > > 20review.pdf > I like the quotation at the top from the YALE guy. > > - Kate D. Word! Cept the theoretic scope of what he said should probably be extended to include not only relapse, but also treatment failure. Do you remember posting that news article about using a protein to wake up dormant Mtb? Long time ago. You dont still have that do you? I think that article must have been about something called resuscitation factor, which is sort of a bacterial hormone. I just want to make sure its not about something else. I am hugely interested in this whole area now. Tho they are colossally active in changing Mtb from a non-replicating to a replicating phenotype, I'm not sure gram positive bacterias resuscitation factors have much therapy value. Whether they could be versatile treatments probably hinges on whether they diffuse across biomembranes, and only a few proteins/peptides do so. However, resuscitation factors of gram negatives are not proteins, but small molecules, according to one reference. Therefore, even if they happen to be the sort of small molecules that dont cross biomembranes well, its not unlikely that one can fix that right up by tacking a big hydrophobic group onto one corner of the molecule. Quote Link to comment Share on other sites More sharing options...
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