Guest guest Posted November 20, 2005 Report Share Posted November 20, 2005 This is from a Candida forum , it very much relates to the chronically ill..It's back to gut flora ..The symbiotic relationship with our gut flora drives our Immune system. In addition to balancing our immunologic act, bacteria perform countless other physiologic tasks .. When you take medicine, it needs to be metabolised in the body. Some medicines work directly on the body, while others need to be converted to another compound (metabolised) because its actually the metabolite that's biologically active. Because most drugs are foreign substances, the body eventually needs to excrete them. Before drugs are brought to market, scientists elicidate its pharmacological pathway...i.e how is it absorbed, transported, how does it interact with the target cells and how is it excreted. Any conversion of 1 compound to another within the body is done by enzymes. The liver can produce literally hundreds of different enzymes to convert various nutrients, chemicals, drugs etc. The raw materials for conversion are enzymes plus nutrients like vitamins and trace minerals If the body doesn't have a detoxification pathway for a particular substance or if the pathway is impaired, then that particular substance will accumulate. That's what makes certain environmental toxins so dangerous....the body simply cannot get rid of them once absorbed, so they remain in the body, blocking receptors, mimicking hormones, deactivating enzymes etc. Genetically, enzyme production is controlled by genes. The more genes are activated, the higher the production capacity of certain enzymes. So by understanding a drug's metabolic pathway, you understand which enzymes are required to metabolise and detoxify the body. If you then look at the rate of expression of the gene responsible for that enzyme, you understand how well the patient is able to process a particular drug. But there's another very key observation to make from all this. Like drugs, enzymes are required to process environmental toxins and the same mechanisms that apply to drugs, apply to environmental toxins. Depending on whether a person makes a particular enzyme will depend on how well they process certain xenobiotics (biologically active compounds absorbed from outside the body). A healthy person with plenty of the right enzyme may have no problem with a relatively high concentration of a particular environmental toxin, while another healthy person who genetically makes far less of the enzyme may find that the toxin quickly accumulates and generates chronic illness. -- No virus found in this outgoing message. Checked by AVG Free Edition. Version: 7.1.362 / Virus Database: 267.13.4/175 - Release Date: 18/11/2005 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 20, 2005 Report Share Posted November 20, 2005 I like it- it makes real good sense. -- In infections , " Jaep " <Jaep@L...> wrote: > > This is from a Candida forum , it very much relates to the chronically > ill..It's back to gut flora ..The symbiotic relationship with our gut flora > drives our Immune system. In addition to balancing our immunologic act, > bacteria perform countless other physiologic tasks .. > > When you take medicine, it needs to be metabolised in the body. Some > medicines work directly on the body, while others need to be converted to > another compound (metabolised) because its actually the metabolite that's > biologically active. Because most drugs are foreign substances, the body > eventually needs to excrete them. Before drugs are brought to market, > scientists elicidate its pharmacological pathway...i.e how is it absorbed, > transported, how does it interact with the target cells and how is it > excreted. Any conversion of 1 compound to another within the body is done by > enzymes. The liver can produce literally hundreds of different enzymes to > convert various nutrients, chemicals, drugs etc. The raw materials for > conversion are enzymes plus nutrients like vitamins and trace minerals If > the body doesn't have a detoxification pathway for a particular substance or > if the pathway is impaired, then that particular substance will accumulate. > That's what makes certain environmental toxins so dangerous....the body > simply cannot get rid of them once absorbed, so they remain in the body, > blocking receptors, mimicking hormones, deactivating enzymes etc. > > Genetically, enzyme production is controlled by genes. The more genes are > activated, the higher the production capacity of certain enzymes. So by > understanding a drug's metabolic pathway, you understand which enzymes are > required to metabolise and detoxify the body. If you then look at the rate > of expression of the gene responsible for that enzyme, you understand how > well the patient is able to process a particular drug. > > But there's another very key observation to make from all this. Like drugs, > enzymes are required to process environmental toxins and the same mechanisms > that apply to drugs, apply to environmental toxins. Depending on whether a > person makes a particular enzyme will depend on how well they process > certain xenobiotics (biologically active compounds absorbed from outside the > body). A healthy person with plenty of the right enzyme may have no problem > with a relatively high concentration of a particular environmental toxin, > while another healthy person who genetically makes far less of the enzyme > may find that the toxin quickly accumulates and generates chronic illness. > -- > No virus found in this outgoing message. > Checked by AVG Free Edition. > Version: 7.1.362 / Virus Database: 267.13.4/175 - Release Date: 18/11/2005 > Quote Link to comment Share on other sites More sharing options...
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