Guest guest Posted November 8, 2005 Report Share Posted November 8, 2005 I also think that a valid hypothesis is for dual infections or even more. There is the complexity of the host MHC, immune system function, nutritional status that interplay with multiple infective agents mainifesting as MS, ALS, Lyme, RA, AI, CFIDS/FM, Alzheimers..... Each pathogenic genome having it's own unique mechanism for coexisting with the host. When the host immune system has multiple pathogenic defenses active comtemporaneously, a syndrome manifests. That's why you can find Candida, EBV, Borellia, Babisisa, Cpn, Staph, mycoplasma and God knows what else in the same sick host. And these little bastards are all talking, or sharing plasmids and other genetic information and tending to their own piece of the real estate. Good luck trying to prove the Koch hypothesis, it's too complex of an interaction. As for binary antibiotic therapy, the approach needs more play and fine tuning from the ID community. I like the idea of throwing a block on protein synthesis and cell wall synthesis at the same time or whatever else works. However, when you take out the bad, you have to put back the good and they do a pretty good job of defending their terf with their own biochemical warfare. Unfortunately, I have found it easier to introduce anerobes to my septic system then it is to find the proper flora for myself. > > I just noticed 2 things. One, rifampin and zith were used in this > study. Isnt rifampin one of the most immunotropic of all abx? Perhaps > that is an empty dogma... I dont have time to chase it down just now. > > Two, rifampin is inactive against all spirochetes. Insofar as evidence > stands today, spiros are as important in MS as Cpn is, and I think > dual infection could be the rule. With respect to any spirochetal > contribution to their illnesses, these subjects were on azithromycin > monotherapy. It would have been preferable to use two drugs active > against borrelia, if possible. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 8, 2005 Report Share Posted November 8, 2005 " I like the idea of throwing a block on protein synthesis and cell wall synthesis at the same time " Yes I do too , so I take Zithromax & Terbinafine [Lamisil] it works very well ..I take 250mg Lamisil for two days then nothing for three days alongside I take 250 Zith every four days, It's not a predicable outcome so its guesswork what's happening.... Lamisil works against the fungal cell wall and zith [they guess] as below ...It's Early days but so far so very very good ... TreatmentUpdate 87 Amphotericin B and azithromycin for aspergillosis? Created on: 1998 May 24 Last Modified on: 1999 August 11 Hosein SR 1998 May Volume 10 Issue 3 Some people with AIDS develop a fungal infection of the lungs called aspergillosis. This disease is not easy to treat and only some people recover when treated with itraconazole. New approaches are clearly needed. Researchers in Florida have been conducting laboratory experiments with the fungus that causes aspergillosis and various drugs. They found that exposure to amphotericin B (AmB) damaged the fungus. When they used a combination of the antibiotic azithromycin (Zithromax) and AmB then there was even greater anti-fungal activity. Apparently azithromycin stops the fungus from building proteins that it needs to survive. By itself, azithromycin had no antifungal activity. The next step, according to the researchers, is to test the combination for safety and effectiveness in animals with aspergillosis. REFERENCES: 1. Nguyen MH, Clancy CJ, Yu YC and AS. Potentiation of antifungal activity of amphotericin B by azithromycin against aspergillus species. European Journal of Clinical Microbiology and Infectious Diseases 1997;16:846-848. [infections] Dual infections I also think that a valid hypothesis is for dual infections or even more. There is the complexity of the host MHC, immune system function, nutritional status that interplay with multiple infective agents mainifesting as MS, ALS, Lyme, RA, AI, CFIDS/FM, Alzheimers..... Each pathogenic genome having it's own unique mechanism for coexisting with the host. When the host immune system has multiple pathogenic defenses active comtemporaneously, a syndrome manifests. That's why you can find Candida, EBV, Borellia, Babisisa, Cpn, Staph, mycoplasma and God knows what else in the same sick host. And these little bastards are all talking, or sharing plasmids and other genetic information and tending to their own piece of the real estate. Good luck trying to prove the Koch hypothesis, it's too complex of an interaction. As for binary antibiotic therapy, the approach needs more play and fine tuning from the ID community. I like the idea of throwing a block on protein synthesis and cell wall synthesis at the same time or whatever else works. However, when you take out the bad, you have to put back the good and they do a pretty good job of defending their terf with their own biochemical warfare. Unfortunately, I have found it easier to introduce anerobes to my septic system then it is to find the proper flora for myself. > > I just noticed 2 things. One, rifampin and zith were used in this > study. Isnt rifampin one of the most immunotropic of all abx? Perhaps > that is an empty dogma... I dont have time to chase it down just now. > > Two, rifampin is inactive against all spirochetes. Insofar as evidence > stands today, spiros are as important in MS as Cpn is, and I think > dual infection could be the rule. With respect to any spirochetal > contribution to their illnesses, these subjects were on azithromycin > monotherapy. It would have been preferable to use two drugs active > against borrelia, if possible. > Quote Link to comment Share on other sites More sharing options...
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