Creatine and Training

[Guest guest]

Kalman writes:

With respect to creatine and these " new " forms of creatine such as

CEE, it should be pointed out that there are NO published studies of

safety, efficacy, absorption, pharmacokinetics or anything close to

what these marketers claim. In fact, the FDA has rejected two or three

New Dietary Ingredient submissions by Ed Byrd's company ( " MRI " , makers

of NO2) last I checked.

Doug:

In my past academic career, I was involved in drug synthesis (making and

testing such things as glutathione derivatives such as glutathione ethyl ester

etc. as scavengers of free radical created either by ionizing radiation and/or

drug metabolism). One thing that I haven't seen addressed by these

companies is the byproduct of creatine ethyl ester metabolism is ethanol

(that's why

you won't see such things and CM (methyl) ester ie. methanol is toxic). So

if you're taking CEE in sufficient quantities, you could conceivably have a

sizable amount of ethanol created as a metabolic byproduct!

I personally have had success with Actijube (there was a recent article

noting its efficacy in JSCR) and it has proven beneficial in my O-L. Basically

one thing one must be concerned with when using creatine is its pH instability.

Some liquid unbuffered forms have been shown to have no activity because all

the creatine has been broken down to creatinine.

Myles B. Astor, PhD

Personal Trainer

Equinox Fitness Clubs

New York, NY US