Possible transmission of sarcoidosis via allogeneic bone marrow transplantation

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Bone Marrow Transplant. 1994 Jul;14(1):161-4. Related Articles,

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Possible transmission of sarcoidosis via allogeneic bone marrow

transplantation.

Heyll A, Meckenstock G, Aul C, Sohngen D, Borchard F, Hadding U,

Modder U, Leschke M, Schneider W.

Department of Internal Medicine, University of Dusseldorf, Germany.

Allogeneic bone marrow transplantation (BMT) was performed in a 34-

year-old man for non-Hodgkin's lymphoma. Two years before bone

marrow harvest, pulmonary sarcoidosis was diagnosed in the donor.

After steroid therapy, disease of the donor was in clinical

remission with only minor radiological signs at the time of BMT. On

day 90 after BMT, active sarcoidosis was diagnosed in the recipient.

Besides radiologic signs and increased angiotensin converting enzyme

levels, diagnosis was proved by characteristic histologic changes in

lung and liver biopsies. Immunosuppressive therapy was changed from

high dose cyclosporine to high dose methylprednisolone and symptoms

promptly resolved within 10 weeks. This case indicates the

possibility of transmission of sarcoidosis by marrow transplantation.

Publication Types:

Case Reports

PMID: 7951107 [PubMed - indexed for MEDLINE]

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Goes to show how deep these infections truly are?

tony

>

> Bone Marrow Transplant. 1994 Jul;14(1):161-4. Related Articles,

> Links

>

>

> Possible transmission of sarcoidosis via allogeneic bone marrow

> transplantation.

>

> Heyll A, Meckenstock G, Aul C, Sohngen D, Borchard F, Hadding U,

> Modder U, Leschke M, Schneider W.

>

> Department of Internal Medicine, University of Dusseldorf, Germany.

>

> Allogeneic bone marrow transplantation (BMT) was performed in a 34-

> year-old man for non-Hodgkin's lymphoma. Two years before bone

> marrow harvest, pulmonary sarcoidosis was diagnosed in the donor.

> After steroid therapy, disease of the donor was in clinical

> remission with only minor radiological signs at the time of BMT.

On

> day 90 after BMT, active sarcoidosis was diagnosed in the

recipient.

> Besides radiologic signs and increased angiotensin converting

enzyme

> levels, diagnosis was proved by characteristic histologic changes

in

> lung and liver biopsies. Immunosuppressive therapy was changed

from

> high dose cyclosporine to high dose methylprednisolone and

symptoms

> promptly resolved within 10 weeks. This case indicates the

> possibility of transmission of sarcoidosis by marrow

transplantation.

>

> Publication Types:

> Case Reports

>

> PMID: 7951107 [PubMed - indexed for MEDLINE]

>