Guest guest Posted November 21, 2005 Report Share Posted November 21, 2005 Doxy and Plaquenil mix OK in most people. Mino and Plaq is another story- as there's definitely an interaction, depending on individual P450 genetics. But you won't find much about it on the web - this is info from my experience and the 2 other people I know who also took Mino and Plaq. Mino can reach toxic levels in the presence of Plaquenil - so both dosages may have to adjusted downward. This combo also depletes B vitamins to the point where my RA friend developed mouth and gum sores- and the flesh of her gums actually peeled away - Sublingual B vits reversed it. (She may have a B vit absorption problem- as oral B didn't aleviate her mouth symptoms, but sublingual did). Plaq. has a very long half life- and after one stops it, there's still detectable amounts in the tissues months later. Fluconazole also has a long half life - and I don't know how that mixes with your drug list without doing more research. I think I remember they both (Fluc & Plaq) inhibit the same pathway- so definitelt check out with enzyme pathways those are for both drugs Doxy and Mino? - is that so you can start with Doxy and work up to Mino (I've never heard of anyone mixing them together) Nystatin doesn't go beyond the intestines- so that's probably OK. I've never taken Malarone- you'll have to reseach that. Also- be carefull if she's on any antidepressants- or any anti- anexiety meds- they interact with alot of other drugs. I assume you Doc knows everything she's on- and has researched these possible interactions? I would definitely consult him or her. Barb PS- this message was edited - to correct repitition. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 22, 2005 Report Share Posted November 22, 2005 Hi Barb, > Mino and Plaq is another story- as there's definitely an interaction, > depending on individual P450 genetics. But you won't find much about > it on the web - this is info from my experience and the 2 other > people I know who also took Mino and Plaq. > > Mino can reach toxic levels in the presence of Plaquenil - so both > dosages may have to adjusted downward. Another worry! She'll talk to the PA and the doctor, and see how it goes. Thanks, Barb. Sue , Upstate New York Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.