Guest guest Posted December 9, 2005 Report Share Posted December 9, 2005 Rats, this paper says the ELISA is 88% sensitive for clinically diseased cattle. Its the subclinical cases that cant be serodiagnosed. http://jds.fass.org/cgi/reprint/81/1/283.pdf It also says there is a strong cell-mediated response in the subclinical disease, but an anergy of cell-mediated immunity in the clinical disease. > > Wow, it looks like es disease is possibly seronegative? Tell me > more, o propitious guardians of knowledge. > > " A diagnostic test that is both sensitive and specific has not yet > been found. " > > > > Adv Vet Sci Comp Med. 1983;27:481-506. > > Diagnosis and control of bovine paratuberculosis (e's disease). > > Riemann HP, Abbas B. > > The literature on e's disease is quite extensive. The disease has > been diagnosed throughout the world in a wide range of domestic and > wild animals, but mainly ruminants. It is of economic importance only > in cattle, sheep, and goats. A diagnostic test that is both sensitive > and specific has not yet been found. This failure may be due either > to the spectral nature of the immune response in an affected animal > or to the impurities of the antigen preparations utilized in the > various tests. Control and eradication of the disease is still in the > research stage. Vaccination has been adopted mainly in Europe, with > apparently satisfactory results. Vaccine evaluation has not always > been correctly carried out. Several other control strategies have > been attempted or suggested. None has been finally evaluated, and the > disease is still a challenging problem. > > Publication Types: > Review > > PMID: 6359837 [PubMed - indexed for MEDLINE] > Quote Link to comment Share on other sites More sharing options...
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