Re: CFS is associated with diminished intracellular perforin

[Guest guest]

That is kind of a strange finding. I'm at home right now (no full-text

access) but remind me if I dont get back to you.

There has been a large review of CFS immune parameters, but, it is by

Simon Wessely. Still, its hard to say there has been all that much

consistency in such studies.

>

> Hi ,

>

> You've offered to get full papers in the past and I wonder if this

> study would be a candidate. The authors say, " A significant reduction

> in the NK cell associated perforin levels in samples

> from CFS patients, compared to healthy controls, was observed. " But

> they don't give any numbers in the abstract.

>

> " ...its analysis may prove useful as a biomarker in the study of CFS. "

> I keep waiting for some research that puts all these biomarkers

> together in one study.

>

> Sue ,

> Upstate New York

> ------------------------

> Date: Wed, 23 Nov 2005 00:11:19 -0500

> From: Fred Springfield <fredspringfield@v...>

> Subject: RES: Chronic fatigue syndrome is associated with diminished

> intracellular perforin

>

> Chronic fatigue syndrome is associated with diminished intracellular

> perforin.

>

> Journal: Clin Exp Immunol. 2005 Dec;142(3):505-11.

>

> Authors: Maher KJ, Klimas NG, Fletcher MA.

>

> Affiliation: Department of Medicine, University of Miami School

> of

> Medicine, Miami, FL, USA.

>

> NLM Citation: PMID: 16297163

>

>

> Summary:

> Chronic fatigue syndrome (CFS) is an illness characterized by

> unexplained

> and prolonged fatigue that is often accompanied by abnormalities of

> immune,

> endocrine and cognitive functions. Diminished natural killer cell

> cytotoxicity (NKCC) is a frequently reported finding. However, the

> molecular basis of this defect of in vitro cytotoxicy has not been

> described.

>

> Perforin is a protein found within intracellular granules of NK and

> cytotoxic T cells and is a key factor in the lytic processes mediated by

> these cells. Quantitative fluorescence flow cytometry was used to the

> intracellular perforin content in CFS subjects and healthy controls. A

> significant reduction in the NK cell associated perforin levels in

> samples

> from CFS patients, compared to healthy controls, was observed. There was

> also an indication of a reduced perforin level within the cytotoxic T

> cells

> of CFS subjects, providing the first evidence, to our knowledge, to

> suggest

> a T cell associated cytotoxic deficit in CFS.

>

> Because perforin is important in immune surveillance and homeostasis of

> the

> immune system, its deficiency may prove to be an important factor in the

> pathogenesis of CFS and its analysis may prove useful as a biomarker in

> the

> study of CFS.

>