Re: Aspirin Tames Staph Bug's Aggressiveness

[Guest guest]

Penny

That is so correct, alot of these inflammatories have the power to

some degree to switch on and off genes that cause havoc.I stumbled

into this by observing that all antinflammatories actucally have

antimicrobial characteristics.One of the agents in tuberculosis

treatmenmts is PAS para amino salicylic acid(sp)..This is delivered

at 12 plus grams a day in TB so I alway's felt we need as many

tricks as possable in our therapy.I find it may be capable of

possably killing the inflammation while the drugs do there killing.

>

> FYI

>

> Aspirin Tames Staph Bug's Aggressiveness

> Tue Jul 22, 4:24 PM ET Add Health - Reuters to My

>

>

> By Will Boggs, MD

>

> NEW YORK (Reuters Health) - Salicylic acid -- the active

ingredient

> of aspirin -- blocks genes in Staphylococcus aureus that make this

> nasty microbe so virulent. If this lab result translates into real-

> world infections, maybe fewer antibiotics will be needed to treat

> it.

>

> A team of scientists, including Dr. Ambrose L. Cheung from

Dartmouth

> Medical School in Hanover, New Hampshire, and Dr. Arnold Bayer

from

> Harbor-UCLA Medical Center in Torrance, California, looked at what

> salicylic acid did to Staph aureus in lab experiments.

>

>

> They found that salicylic acid, at levels that could safely be

> reached in blood, substantially reduced the ability of the microbe

> to attach to components in blood. Consequently, the extent of

blood

> destruction was reduced. Salicylic acid also turned off genes in

the

> microbe that produce a characteristic toxin.

>

>

> According to the researchers' report in the Journal of Clinical

> Investigation, they then studied the effect of salicylic acid on

> rabbits infected with Staph aureus.

>

>

> The dose of salicylic acid had to be just right, Dr. Cheung told

> Reuters Health, " With too low a dose being ineffective, while too

> high a dose caused a paradoxical loss of effectiveness. "

>

>

> It now seems possible to blunt a common infectious agent " without

> actually inhibiting the overall growth of the organism or killing

> it, " Dr. Cheung said. " Such 'smart targeting' offers a novel

> approach to antimicrobial therapy as an adjunct to conventional

> antibiotic agents. "

>

>

> In a journal editorial, Dr. Mathias Herrmann from University of

> Saarland in Homburg/Saar, Germany, calls the research an " exciting

> new prospect for a widely used and established drug. "

>

>

> SOURCE: Journal of Clinical Investigation, July 2003.

>

[Guest guest]

Another possibility is huge doses of ascorbic acid, not for the

vitamin c but for the ascorbate which is a free radical mop, thus

dampening hte inflammatory/cytokine/free radical production that is

either a consequence of, or necessary to perpetuate, the infection.

> >

> > FYI

> >

> > Aspirin Tames Staph Bug's Aggressiveness

> > Tue Jul 22, 4:24 PM ET Add Health - Reuters to My

> >

> >

> > By Will Boggs, MD

> >

> > NEW YORK (Reuters Health) - Salicylic acid -- the active

> ingredient

> > of aspirin -- blocks genes in Staphylococcus aureus that make

this

> > nasty microbe so virulent. If this lab result translates into

real-

> > world infections, maybe fewer antibiotics will be needed to treat

> > it.

> >

> > A team of scientists, including Dr. Ambrose L. Cheung from

> Dartmouth

> > Medical School in Hanover, New Hampshire, and Dr. Arnold Bayer

> from

> > Harbor-UCLA Medical Center in Torrance, California, looked at

what

> > salicylic acid did to Staph aureus in lab experiments.

> >

> >

> > They found that salicylic acid, at levels that could safely be

> > reached in blood, substantially reduced the ability of the

microbe

> > to attach to components in blood. Consequently, the extent of

> blood

> > destruction was reduced. Salicylic acid also turned off genes in

> the

> > microbe that produce a characteristic toxin.

> >

> >

> > According to the researchers' report in the Journal of Clinical

> > Investigation, they then studied the effect of salicylic acid on

> > rabbits infected with Staph aureus.

> >

> >

> > The dose of salicylic acid had to be just right, Dr. Cheung told

> > Reuters Health, " With too low a dose being ineffective, while too

> > high a dose caused a paradoxical loss of effectiveness. "

> >

> >

> > It now seems possible to blunt a common infectious agent " without

> > actually inhibiting the overall growth of the organism or killing

> > it, " Dr. Cheung said. " Such 'smart targeting' offers a novel

> > approach to antimicrobial therapy as an adjunct to conventional

> > antibiotic agents. "

> >

> >

> > In a journal editorial, Dr. Mathias Herrmann from University of

> > Saarland in Homburg/Saar, Germany, calls the research

an " exciting

> > new prospect for a widely used and established drug. "

> >

> >

> > SOURCE: Journal of Clinical Investigation, July 2003.

> >

>