Guest guest Posted September 26, 2005 Report Share Posted September 26, 2005 More on immune defence , substitute stealth pathogen cells for cancer cells ... Professor Toy of Cancer Research said: "There's a lot of promising early research suggesting that it may be possible to adapt the body's immune defence system to recognise cancer cells and destroy them. "The real challenge in immunotherapy is to generate T cells able to identify cancer cells and kill them and not be deceived into ignoring them as acceptable versions of normal cells." -----Original Message-----From: infections [mailto:infections ]On Behalf Of JaepSent: 26 September 2005 18:25infections Subject: [infections] Very good news This is exiting news, an immune boost of mega proportions using standard drugs, To my mind it this could be designed just for stealth infections ...Knock back the infection with ABx's ..Control inflammation, boost the IS ..Could be the answer Sept. 23, 2005 -- An important family of anti-HIV drugs may boost the immune systems of people not infected with the AIDS virus.The drugs, called protease inhibitors, are specifically designed to attack a major HIV enzyme. But accumulating evidence suggests that they do much more. The drugs apparently increase production of T cells, a crucial component of the immune system.T cells -- produced in the thymus -- are the kind of cell that HIV loves to infect. T cell numbers increase in people treated with AIDS drugs. That, nearly everyone thought, is because lowering the amount of HIV in the body allows a rebound in T cells.Now there's evidence that protease inhibitors may do more than fight HIV. Mayo Clinic immunologists McKean, PhD, and Badley, MD, led a team that looked at what happens to T cells when people who don't have HIV take AIDS drugs.The researchers looked at seven adult health care workers who took the drugs because they'd had possible exposure to HIV. None of the health care workers became infected.But five of the seven had a huge increase -- up to 1,000-fold -- in brand-new T cells. This seemed to be due to Viracept, a protease inhibitor they took in combination with a different kind of AIDS drug called Combivir. Neither of the two drugs that make up Combivir is thought to directly increase T cells."We think the protease inhibitors are responsible for these naive T cells," McKean tells WebMD. "There is no evidence the other antiviral drugs have any effect on the thymus."Cancer VaccineWhat makes this finding exciting is that the new T cells did not turn around and attack the body. In mouse experiments the new cells appeared ready to fight disease. That could be a big help for elderly patients as people make fewer and fewer new T cells as they age."The ability of [AIDS drugs] to boost T-cell numbers may allow patients who normally don't respond to vaccines -- such as those with chronic disease, or the elderly -- to mount an effective immune response," Badley says in a news release.Perhaps the most exciting part of the new findings is that AIDS drugs could provide an army of new T cells to fight cancer. McKean says cancer vaccines tend to fail because tumors suppress antitumor immune responses."If we can use [AIDS drugs] to increase the number of newly produced T cells in cancer patients, we can potentially improve the likelihood of getting a cancer vaccine to work," he says.McKean and colleagues report their findings in the current issue of the journal AIDS. http://my.webmd.com/content/Article/112/110428.htm?z=1728_00000_1000_tn_04 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 26, 2005 Report Share Posted September 26, 2005 These things are great, sound great get our attention, unfortunately often ther 10 years away.Then the ten years expires and somehow they didn't cut it. tony > More on immune defence , substitute stealth pathogen cells for cancer cells > ... > Professor Toy of Cancer Research said: " There's a lot of promising > early research suggesting that it may be possible to adapt the body's immune > defence system to recognise cancer cells and destroy them. > > " The real challenge in immunotherapy is to generate T cells able to identify > cancer cells and kill them and not be deceived into ignoring them as > acceptable versions of normal cells. " > > > > > > > > > > [infections] Very good news > > > This is exiting news, an immune boost of mega proportions using standard > drugs, To my mind it this could be designed just for stealth infections > ...Knock back the infection with ABx's ..Control inflammation, boost the IS > ..Could be the answer > > Sept. 23, 2005 -- An important family of anti-HIV drugs may boost the > immune systems of people not infected with the AIDS virus. > > The drugs, called protease inhibitors, are specifically designed to attack > a major HIV enzyme. But accumulating evidence suggests that they do much > more. The drugs apparently increase production of T cells, a crucial > component of the immune system. > > T cells -- produced in the thymus -- are the kind of cell that HIV loves > to infect. T cell numbers increase in people treated with AIDS drugs. That, > nearly everyone thought, is because lowering the amount of HIV in the body > allows a rebound in T cells. > > Now there's evidence that protease inhibitors may do more than fight HIV. > Mayo Clinic immunologists McKean, PhD, and Badley, MD, led a > team that looked at what happens to T cells when people who don't have HIV > take AIDS drugs. > > The researchers looked at seven adult health care workers who took the > drugs because they'd had possible exposure to HIV. None of the health care > workers became infected. > > But five of the seven had a huge increase -- up to 1,000-fold -- in > brand-new T cells. This seemed to be due to Viracept, a protease inhibitor > they took in combination with a different kind of AIDS drug called Combivir. > Neither of the two drugs that make up Combivir is thought to directly > increase T cells. > > " We think the protease inhibitors are responsible for these naive T > cells, " McKean tells WebMD. " There is no evidence the other antiviral drugs > have any effect on the thymus. " > > Cancer Vaccine > > What makes this finding exciting is that the new T cells did not turn > around and attack the body. In mouse experiments the new cells appeared > ready to fight disease. That could be a big help for elderly patients as > people make fewer and fewer new T cells as they age. > > " The ability of [AIDS drugs] to boost T-cell numbers may allow patients > who normally don't respond to vaccines -- such as those with chronic > disease, or the elderly -- to mount an effective immune response, " Badley > says in a news release. > > Perhaps the most exciting part of the new findings is that AIDS drugs > could provide an army of new T cells to fight cancer. McKean says cancer > vaccines tend to fail because tumors suppress antitumor immune responses. > > " If we can use [AIDS drugs] to increase the number of newly produced T > cells in cancer patients, we can potentially improve the likelihood of > getting a cancer vaccine to work, " he says. > > McKean and colleagues report their findings in the current issue of the > journal AIDS. > > > > > > http://my.webmd.com/content/Article/112/110428.htm? z=1728_00000_1000_tn_ > 04 > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 26, 2005 Report Share Posted September 26, 2005 Look on the bright side Tony, The drugs are avialable NOW ...http://news.bbc.co.uk/1/hi/health/4274430.stm [infections] Very good news> > > This is exiting news, an immune boost of mega proportions using standard> drugs, To my mind it this could be designed just for stealth infections> ...Knock back the infection with ABx's ..Control inflammation, boost the IS> ..Could be the answer> > Sept. 23, 2005 -- An important family of anti-HIV drugs may boost the> immune systems of people not infected with the AIDS virus.> > The drugs, called protease inhibitors, are specifically designed to attack> a major HIV enzyme. But accumulating evidence suggests that they do much> more. The drugs apparently increase production of T cells, a crucial> component of the immune system.> > T cells -- produced in the thymus -- are the kind of cell that HIV loves> to infect. T cell numbers increase in people treated with AIDS drugs. That,> nearly everyone thought, is because lowering the amount of HIV in the body> allows a rebound in T cells.> > Now there's evidence that protease inhibitors may do more than fight HIV.> Mayo Clinic immunologists McKean, PhD, and Badley, MD, led a> team that looked at what happens to T cells when people who don't have HIV> take AIDS drugs.> > The researchers looked at seven adult health care workers who took the> drugs because they'd had possible exposure to HIV. None of the health care> workers became infected.> > But five of the seven had a huge increase -- up to 1,000-fold -- in> brand-new T cells. This seemed to be due to Viracept, a protease inhibitor> they took in combination with a different kind of AIDS drug called Combivir.> Neither of the two drugs that make up Combivir is thought to directly> increase T cells.> > "We think the protease inhibitors are responsible for these naive T> cells," McKean tells WebMD. "There is no evidence the other antiviral drugs> have any effect on the thymus."> > Cancer Vaccine> > What makes this finding exciting is that the new T cells did not turn> around and attack the body. In mouse experiments the new cells appeared> ready to fight disease. That could be a big help for elderly patients as> people make fewer and fewer new T cells as they age.> > "The ability of [AIDS drugs] to boost T-cell numbers may allow patients> who normally don't respond to vaccines -- such as those with chronic> disease, or the elderly -- to mount an effective immune response," Badley> says in a news release.> > Perhaps the most exciting part of the new findings is that AIDS drugs> could provide an army of new T cells to fight cancer. McKean says cancer> vaccines tend to fail because tumors suppress antitumor immune responses.> > "If we can use [AIDS drugs] to increase the number of newly produced T> cells in cancer patients, we can potentially improve the likelihood of> getting a cancer vaccine to work," he says.> > McKean and colleagues report their findings in the current issue of the> journal AIDS.> > > > > > http://my.webmd.com/content/Article/112/110428.htm?z=1728_00000_1000_tn_> 04> > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 26, 2005 Report Share Posted September 26, 2005 I like it, don't get me wrong, it's just the medical system has been giving us newsbites for years and nothing seems to change.Also what's the chance cheney and co will make this available anytime soon to there patients. Again overall I'm a big fan of many drugs, because they all target many of our problems. > > More on immune defence , substitute stealth pathogen cells for > cancer cells > > ... > > Professor Toy of Cancer Research said: " There's a lot of > promising > > early research suggesting that it may be possible to adapt the > body's immune > > defence system to recognise cancer cells and destroy them. > > > > " The real challenge in immunotherapy is to generate T cells able > to identify > > cancer cells and kill them and not be deceived into ignoring them > as > > acceptable versions of normal cells. " > > > > > > > > > > > > > > > > > > > > [infections] Very good news > > > > > > This is exiting news, an immune boost of mega proportions > using standard > > drugs, To my mind it this could be designed just for stealth > infections > > ...Knock back the infection with ABx's ..Control inflammation, > boost the IS > > ..Could be the answer > > > > Sept. 23, 2005 -- An important family of anti-HIV drugs may > boost the > > immune systems of people not infected with the AIDS virus. > > > > The drugs, called protease inhibitors, are specifically designed > to attack > > a major HIV enzyme. But accumulating evidence suggests that they > do much > > more. The drugs apparently increase production of T cells, a > crucial > > component of the immune system. > > > > T cells -- produced in the thymus -- are the kind of cell that > HIV loves > > to infect. T cell numbers increase in people treated with AIDS > drugs. That, > > nearly everyone thought, is because lowering the amount of HIV in > the body > > allows a rebound in T cells. > > > > Now there's evidence that protease inhibitors may do more than > fight HIV. > > Mayo Clinic immunologists McKean, PhD, and Badley, > MD, led a > > team that looked at what happens to T cells when people who don't > have HIV > > take AIDS drugs. > > > > The researchers looked at seven adult health care workers who > took the > > drugs because they'd had possible exposure to HIV. None of the > health care > > workers became infected. > > > > But five of the seven had a huge increase -- up to 1,000- fold -- > in > > brand-new T cells. This seemed to be due to Viracept, a protease > inhibitor > > they took in combination with a different kind of AIDS drug called > Combivir. > > Neither of the two drugs that make up Combivir is thought to > directly > > increase T cells. > > > > " We think the protease inhibitors are responsible for these > naive T > > cells, " McKean tells WebMD. " There is no evidence the other > antiviral drugs > > have any effect on the thymus. " > > > > Cancer Vaccine > > > > What makes this finding exciting is that the new T cells did not > turn > > around and attack the body. In mouse experiments the new cells > appeared > > ready to fight disease. That could be a big help for elderly > patients as > > people make fewer and fewer new T cells as they age. > > > > " The ability of [AIDS drugs] to boost T-cell numbers may allow > patients > > who normally don't respond to vaccines -- such as those with > chronic > > disease, or the elderly -- to mount an effective immune response, " > Badley > > says in a news release. > > > > Perhaps the most exciting part of the new findings is that AIDS > drugs > > could provide an army of new T cells to fight cancer. McKean says > cancer > > vaccines tend to fail because tumors suppress antitumor immune > responses. > > > > " If we can use [AIDS drugs] to increase the number of newly > produced T > > cells in cancer patients, we can potentially improve the > likelihood of > > getting a cancer vaccine to work, " he says. > > > > McKean and colleagues report their findings in the current issue > of the > > journal AIDS. > > > > > > > > > > > > http://my.webmd.com/content/Article/112/110428.htm? > z=1728_00000_1000_tn_ > > 04 > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 27, 2005 Report Share Posted September 27, 2005 It's a chance we didn't have before, The fact that many feel an improvement when hosting a "guest" infection does fuel the argument for some sort of an immune modulator to overcome the anergy we display . I thought perhaps Interleukin-6 (IL-6) would suit , but the chances of obtaining that are slim to say the least. This maybe the answer, Also we need to know how restore Lactic acid bacteria in the gut [infections] Very good news> >> >> > This is exiting news, an immune boost of mega proportions> using standard> > drugs, To my mind it this could be designed just for stealth> infections> > ...Knock back the infection with ABx's ..Control inflammation,> boost the IS> > ..Could be the answer> >> > Sept. 23, 2005 -- An important family of anti-HIV drugs may> boost the> > immune systems of people not infected with the AIDS virus.> >> > The drugs, called protease inhibitors, are specifically designed> to attack> > a major HIV enzyme. But accumulating evidence suggests that they> do much> > more. The drugs apparently increase production of T cells, a> crucial> > component of the immune system.> >> > T cells -- produced in the thymus -- are the kind of cell that> HIV loves> > to infect. T cell numbers increase in people treated with AIDS> drugs. That,> > nearly everyone thought, is because lowering the amount of HIV in> the body> > allows a rebound in T cells.> >> > Now there's evidence that protease inhibitors may do more than> fight HIV.> > Mayo Clinic immunologists McKean, PhD, and Badley,> MD, led a> > team that looked at what happens to T cells when people who don't> have HIV> > take AIDS drugs.> >> > The researchers looked at seven adult health care workers who> took the> > drugs because they'd had possible exposure to HIV. None of the> health care> > workers became infected.> >> > But five of the seven had a huge increase -- up to 1,000-fold --> in> > brand-new T cells. This seemed to be due to Viracept, a protease> inhibitor> > they took in combination with a different kind of AIDS drug called> Combivir.> > Neither of the two drugs that make up Combivir is thought to> directly> > increase T cells.> >> > "We think the protease inhibitors are responsible for these> naive T> > cells," McKean tells WebMD. "There is no evidence the other> antiviral drugs> > have any effect on the thymus."> >> > Cancer Vaccine> >> > What makes this finding exciting is that the new T cells did not> turn> > around and attack the body. In mouse experiments the new cells> appeared> > ready to fight disease. That could be a big help for elderly> patients as> > people make fewer and fewer new T cells as they age.> >> > "The ability of [AIDS drugs] to boost T-cell numbers may allow> patients> > who normally don't respond to vaccines -- such as those with> chronic> > disease, or the elderly -- to mount an effective immune response,"> Badley> > says in a news release.> >> > Perhaps the most exciting part of the new findings is that AIDS> drugs> > could provide an army of new T cells to fight cancer. McKean says> cancer> > vaccines tend to fail because tumors suppress antitumor immune> responses.> >> > "If we can use [AIDS drugs] to increase the number of newly> produced T> > cells in cancer patients, we can potentially improve the> likelihood of> > getting a cancer vaccine to work," he says.> >> > McKean and colleagues report their findings in the current issue> of the> > journal AIDS.> >> >> >> >> >> > http://my.webmd.com/content/Article/112/110428.htm?> z=1728_00000_1000_tn_> > 04> >> >> >> > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 27, 2005 Report Share Posted September 27, 2005 These drugs are not to be taken lightly. I don't view this in such a sanguine way. Immune modulation can cause problems--as you may have noticed with remicaid, and the new drug tysabri that was pulled (for MS patients) because some got PML and in a few cases it was fatal. That also occurs with all other immunomodulators. I would rather kill the infection than tamper with nature, unless the infection is seriously fatal (as per AIDS). Not that this isn't an interesting direction but I completely agree w/ Tony its way down the line before we know how to use them and what their downsides are. > > > More on immune defence , substitute stealth pathogen cells for > > cancer cells > > > ... > > > Professor Toy of Cancer Research said: " There's a lot of > > promising > > > early research suggesting that it may be possible to adapt the > > body's immune > > > defence system to recognise cancer cells and destroy them. > > > > > > " The real challenge in immunotherapy is to generate T cells > able > > to identify > > > cancer cells and kill them and not be deceived into ignoring > them > > as > > > acceptable versions of normal cells. " > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > [infections] Very good news > > > > > > > > > This is exiting news, an immune boost of mega proportions > > using standard > > > drugs, To my mind it this could be designed just for stealth > > infections > > > ...Knock back the infection with ABx's ..Control inflammation, > > boost the IS > > > ..Could be the answer > > > > > > Sept. 23, 2005 -- An important family of anti-HIV drugs may > > boost the > > > immune systems of people not infected with the AIDS virus. > > > > > > The drugs, called protease inhibitors, are specifically > designed > > to attack > > > a major HIV enzyme. But accumulating evidence suggests that > they > > do much > > > more. The drugs apparently increase production of T cells, a > > crucial > > > component of the immune system. > > > > > > T cells -- produced in the thymus -- are the kind of cell > that > > HIV loves > > > to infect. T cell numbers increase in people treated with AIDS > > drugs. That, > > > nearly everyone thought, is because lowering the amount of HIV > in > > the body > > > allows a rebound in T cells. > > > > > > Now there's evidence that protease inhibitors may do more > than > > fight HIV. > > > Mayo Clinic immunologists McKean, PhD, and Badley, > > MD, led a > > > team that looked at what happens to T cells when people who > don't > > have HIV > > > take AIDS drugs. > > > > > > The researchers looked at seven adult health care workers who > > took the > > > drugs because they'd had possible exposure to HIV. None of the > > health care > > > workers became infected. > > > > > > But five of the seven had a huge increase -- up to 1,000- > fold -- > > in > > > brand-new T cells. This seemed to be due to Viracept, a > protease > > inhibitor > > > they took in combination with a different kind of AIDS drug > called > > Combivir. > > > Neither of the two drugs that make up Combivir is thought to > > directly > > > increase T cells. > > > > > > " We think the protease inhibitors are responsible for these > > naive T > > > cells, " McKean tells WebMD. " There is no evidence the other > > antiviral drugs > > > have any effect on the thymus. " > > > > > > Cancer Vaccine > > > > > > What makes this finding exciting is that the new T cells did > not > > turn > > > around and attack the body. In mouse experiments the new cells > > appeared > > > ready to fight disease. That could be a big help for elderly > > patients as > > > people make fewer and fewer new T cells as they age. > > > > > > " The ability of [AIDS drugs] to boost T-cell numbers may > allow > > patients > > > who normally don't respond to vaccines -- such as those with > > chronic > > > disease, or the elderly -- to mount an effective immune > response, " > > Badley > > > says in a news release. > > > > > > Perhaps the most exciting part of the new findings is that > AIDS > > drugs > > > could provide an army of new T cells to fight cancer. McKean > says > > cancer > > > vaccines tend to fail because tumors suppress antitumor immune > > responses. > > > > > > " If we can use [AIDS drugs] to increase the number of newly > > produced T > > > cells in cancer patients, we can potentially improve the > > likelihood of > > > getting a cancer vaccine to work, " he says. > > > > > > McKean and colleagues report their findings in the current > issue > > of the > > > journal AIDS. > > > > > > > > > > > > > > > > > > http://my.webmd.com/content/Article/112/110428.htm? > > z=1728_00000_1000_tn_ > > > 04 > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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