Membrane Damaging Toxins from Coagulase-Negative Staphylococcus Areus

[Guest guest]

Journal of Chronic Fatigue Syndrome:

Multidisciplinary Innovations in Research, Theory, and Clinical

Practice Volume: 12 Issue: 3

ISSN: 1057-3321 Pub Date: 10/5/2005

Page Range: 25 - 43

Membrane Damaging Toxins from Coagulase-Negative Staphylococcus Are

Associated with Self-Reported Temporomandibular Disorder (TMD) in

Patients with Chronic Fatigue Syndrome

• Lee N. Metcalf BSc, Bioanalytical Research Group, Department

of Biological Sciences, University of New Castle, Callaghan, NSW

2308, Australia

• Neil R. McGregor MDSc PhD, Jaw and Oro-facial Pain Research

Unit, Centre for Oral Health Research, Bio21 Molecular Science and

Biotechnology Institute, University of Sydney, University of

Melbourne, Parkville, VIC, 3012, Australia, binrm@...

• K. PhD, Bioanalytical Research Group,

Department of Biological Sciences, University of Newcastle,

Callaghan, NSW 2308, Australia

Abstract:

Aim: To assess whether there is any association between membrane

damaging toxin production by Staphylococcus spp. and self-reported

TMD symptom expression in a group of patients selected to have CFS.

Methods: Thirty-three defined Chronic Fatigue Syndrome (CFS) patients

and 33 ageand sex-matched controls were assessed to evaluate the

relationship between carriage of membrane damaging toxin producing

staphylococcus, CFS and temporomandibular dysfunction (TMD) symptoms.

Results: The CFS patients had an increased prevalence of face pain

(Odds Ratio = 21.0, 95% CL 4.2-106, P < .001) and temporomandibular

joint (TMJ) clicking/locking (OR = 5.7, 95% CL 1.423.5, P < .007),

and the coagulase-negative staphylococcus maximum% B*-toxin

haemolysis per patient.

Both multivariate and univariate analyses revealed an association

between the membrane damaging o*-toxin producing CoNS (MDT-CoNS)

species per subject and face pain prevalence and intensity within

both the CFS patients and the control subjects. No association was

found between CoNS toxin production and TMJ clicking/locking.

Importantly, áand B*-toxin production by CoNS was associated with

patient reporting of arthritis. Conclusions: These data confirm the

original observations of the association between MDTCoNS and facial

muscle pain (Butt et al, 1998; McGregor et al, 2003). These data also

suggest that MDT-CoNS associated facial muscle pain expression

represents a distinct clinical entity, which has an increased

prevalence in CFS patients

[Guest guest]

Peg,

Was your osteomyelitis successfully cultured? Did it turn out to be

coag. neg. staph epidermidis, coag neg. staph [areus {?}]? What other

bacteria were found? Thanks.

>

> Journal of Chronic Fatigue Syndrome:

> Multidisciplinary Innovations in Research, Theory, and Clinical

> Practice Volume: 12 Issue: 3

> ISSN: 1057-3321 Pub Date: 10/5/2005

> Page Range: 25 - 43

> Membrane Damaging Toxins from Coagulase-Negative Staphylococcus Are

> Associated with Self-Reported Temporomandibular Disorder (TMD) in

> Patients with Chronic Fatigue Syndrome

> • Lee N. Metcalf BSc, Bioanalytical Research Group, Department

> of Biological Sciences, University of New Castle, Callaghan, NSW

> 2308, Australia

> • Neil R. McGregor MDSc PhD, Jaw and Oro-facial Pain Research

> Unit, Centre for Oral Health Research, Bio21 Molecular Science and

> Biotechnology Institute, University of Sydney, University of

> Melbourne, Parkville, VIC, 3012, Australia, binrm@b...

> • K. PhD, Bioanalytical Research Group,

> Department of Biological Sciences, University of Newcastle,

> Callaghan, NSW 2308, Australia

> Abstract:

>

> Aim: To assess whether there is any association between membrane

> damaging toxin production by Staphylococcus spp. and self-reported

> TMD symptom expression in a group of patients selected to have CFS.

> Methods: Thirty-three defined Chronic Fatigue Syndrome (CFS)

patients

> and 33 ageand sex-matched controls were assessed to evaluate the

> relationship between carriage of membrane damaging toxin producing

> staphylococcus, CFS and temporomandibular dysfunction (TMD)

symptoms.

> Results: The CFS patients had an increased prevalence of face pain

> (Odds Ratio = 21.0, 95% CL 4.2-106, P < .001) and temporomandibular

> joint (TMJ) clicking/locking (OR = 5.7, 95% CL 1.423.5, P < .007),

> and the coagulase-negative staphylococcus maximum% B*-toxin

> haemolysis per patient.

> Both multivariate and univariate analyses revealed an association

> between the membrane damaging o*-toxin producing CoNS (MDT-CoNS)

> species per subject and face pain prevalence and intensity within

> both the CFS patients and the control subjects. No association was

> found between CoNS toxin production and TMJ clicking/locking.

> Importantly, áand B*-toxin production by CoNS was associated with

> patient reporting of arthritis. Conclusions: These data confirm the

> original observations of the association between MDTCoNS and facial

> muscle pain (Butt et al, 1998; McGregor et al, 2003). These data

also

> suggest that MDT-CoNS associated facial muscle pain expression

> represents a distinct clinical entity, which has an increased

> prevalence in CFS patients

>