interesting one (free full text) re pathogenesis of lupus

[Guest guest]

http://www.jmii.org/content/abstracts/v34n4p265.php

THis is obviously 5 billion times more relevant than some screwed up

mutant mouse that starts spewing antinuclear antibodies as soon as you

look it in the eye.

THis certainly seems to suggest that pathogenic autoreactivity exists

in some of these mothers, tho it may not be inconceivable that the

effects could be microbe-mediated - a baby might have a better hand of

cards than the mother and might be able to clear a microbe once

transplacental influx ceased? I dont know if the rate of

transplacental microbial migration is large enough to support this

model. And the paper claims the association with the particular

maternal autoAb is strong.

Its interesting that most mothers with SLE have babies without

neonatal lupus syndrome, and that the majority of NLS babies have

clinically well mothers.