Guest guest Posted October 16, 2005 Report Share Posted October 16, 2005 My criticism of this work would be that one should not use only healthy IgG as a control. Using IgG from another disease state would be better. Otherwise its rather convincing. ============================================================= Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease Anhalt, G J; Labib, R S; Voorhees, J J; Beals, T F; , L A Abstract We examined the role of circulating autoantibodies in the pathogenesis of pemphigus vulgaris by passively transferring IgG fractions from five patients with pemphigus vulgaris into neonatal Balb/c mice, in doses of 1.5 to 16 mg per gram of body weight per day. Cutaneous blisters and erosions with the histologic, ultrastructural, and immunofluorescence features of pemphigus occurred in 39 to 55 mice given intraperitoneal injections of IgG from patients with pemphigus and in none of 58 control mice given normal human IgG. IgG fractions with high titers of pemphigus antibodies were most effective in inducing disease, and this effect was dose dependent. Titers of circulating IgG in mouse serum closely correlated with the extent of disease induced (P less than 0.002). This study strongly supports the proposed role of pemphigus autoantibodies in the pathogenesis of pemphigus vulgaris in human beings and demonstrates that pemphigus can be passively transferred to laboratory animals. [Journal Article; In English; United States] Quote Link to comment Share on other sites More sharing options...
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