Re: Re: Question for J. (or fungally interested bystanders)

[Guest guest]

On Sunday, October 9, 2005, at 11:29 AM, dumbaussie2000 wrote:

>

> Love the dosages for the antifungals. I think this is getting

> realistic about tackling infections properly. Actually that's the

> first I heard anyone say triple antifungal therapy anywhere. I

> actually don't know anyone that has recommended  8 million units of

> nystatin either. My best for the day was 25 million.loved that drug.

So Tony, if i remember correctly, Nystatin doesn't help you anymore?

How do I avoid this? By taking it with other drugs? By taking large

doses and then going on to something else? Or is it just inevitable

that I am going to go down the path that others have talked about where

something helps at first and then doesn't and the # of helpful drugs

gets smaller as one progresses?

- Kate

[Guest guest]

On Sunday, October 9, 2005, at 04:44 PM, wrote:

> I read it with a grain of Schardt

eh?

> For me tini is a big offender re amping up the yeast on my tongue,

> contra the hopes expressed at the end of the Brorson tini paper.

Ahah. I thought maybe it was the Ketek, but interesting to know that

Tini could be guilty as well.

> All thru my year of abx, I am seeing some really discommoding

> fungitudeinousness in the south polar latitudes anytime I wear pants

> or underwear which are not 100% cotton. I think most long underwear

> comprises synth fibers in part so I am gonna have to buy some all-

> cotton ones when it gets cold.

That's a good way of putting it. Unfortunately, I am already a cotton

person and can't make that an improvement. Well, assuming a couple of

percent lycra in the long underwear is okay....

> In all cases above, my microbe was self-ID'd as yeast by its scent of

> unbaked bread dough. I am assuming that is probably a good criterion.

That sounds reasonable. My ID is based on the fact that the irritation

goes away with over-the-counter yeast treatment. Unfortunately it comes

back as long as I am taking the abx.

- Kate

[Guest guest]

On Sunday, October 9, 2005, at 09:46 PM, dumbaussie2000 wrote re

NYSTATIN:

> The good thing was that it really didn't turn easily. I just

> monitored it's antibacterial properties and noticed that after using

> it initially and feeling great then stopping- thinking I did enough-

> my second round with the drug was positive, but after a long while

> without a gameplan it just doesn't cut it anymore. Although I will

> still notice benefits from it's ability in the sinus to keep

> pseudonomas at bay.

Sounds good. That's all a bonus then to using it for fungus then. I did

read Cranton, as suggested. He says Nystatin works simply by

coating the stomach, so it doesn't sound to me like that type of action

would stop being effective -- unless a fungal infection just got so big

that it overwhelmed it.

About the GAMEPLAN. Yah, I am trying to come up with one of those. So

far I like the Tini thing, although I'm not sure that using it

continuously like I am is the best way to use it. I also like what Barb

did with HCQ. I don't know if I can keep paying for Ketek, or whether

it's doing its job. I'll just have to see.

> Your mission should be focused on the head, sinus, getting it

> sterilised  whatever it takes.

Well, I'm one of those stubborn people that doesn't see any obvious

head symptoms and thinks I mainly have Lyme! Although I do suspect at

one point I accumulated something else because things deteriorated five

years into my undiagnosed, untreated illness (the condition my doc told

me probably would not get worse).

> So

> regardless of the drug make sure your doing enough of everything to

> keep this getting better and the drug and it's use won't be up in

> the air only scrapping the surface of the problem.

I'm definitely starting to see the merit of this approach.

- Kate

[Guest guest]

On Sunday, October 9, 2005, at 10:57 PM, wrote:

>

> > > I read it with a grain of Schardt

> >

> > eh?

>

> He of the fluconazole anti-Bb protocol. His findings make it harder

> to interpret whats dying in Crantons patients when they take combos

> which include fluc.

I knew about Schardt but didn't try to put his data together with

Cranton's in my head because it was beyond me. Well, I guess I just

didn't want to have to think that hard right now. Sometimes I get lazy

and want somebody else to give me the answer.

> I guess the question is, persisters or new infection? If its

> persisters, and they dont become resistant, they must be the non-

> mutant, Kim kinda persisters that ride out the drugs via

> torpor. Or perhaps mutants who are rapidly outcompeted by revertants

> when the drug is withdrawn (revertants are mutants that mutate back

> to the wild type.. and if a mutant cell replicates in 1 hours and a

> wild type in 57 mintues, it adds up to a big difference before too

> long).

>

> C. albicans is definitely ubiquitous so it prolly also is plenty easy

> to get reinfected.

Yah, I'm worried about mutants. Since it so thoroughly goes away with

local treatment though, I was thinking maybe it's just coming back

because it's elsewhere in my body too.

> Anyway you might want to dredge some colossal database like the

> lymenet archives to see whats worked long-term for someone/anyone.

I'll have to see if the search engine works for me now. It didn't in

the past but maybe they fixed it?

Thanks for the suggestions,

- Kate

[Guest guest]

I thought it sounded weird that it could just work by coating the

stomach. He ought to rewrite that sentence. I dunno why, I just assumed

that yeast resistance would turn out to be a problem. 's Law, you

know! Gee, that would be nice if it's not a problem, 'cause if one is

taking long-term abx, one can't just treat it and beat it.

- Kate

On Sunday, October 9, 2005, at 11:41 PM, wrote:

>

> > Having a specific action doesnt guaruntee that resistance occurs,

> but I would guess it probably does.

>

> I mean in the lab, at least. Maybe pubmed could tell you whether yeast

> resistance is a clinical problem (for people not semi-permanently on

> abx, anyway).

>> By that Cranton just means (I hope) that its affinity for the mucosa

>> helps get/stay concentrated where its needed. It does have a specific

>> molecular action against the yeast, which is membrane permeabilization

>> according to _Biochem. of Antimicrob. Action._

>>

>> > read Cranton, as suggested. He says Nystatin works simply by

>> > coating the stomach, so it doesn't sound to me like that type of

>> action

>> > would stop being effective

[Guest guest]

Okay, I had this bookmarked and forgot about it. Probably J. or

somebody posted it once and I actually was paying attention.

http://www.medscape.com/viewarticle/412677_5

Antifungal Resistance Among Candida Species

It talks about resistance to fluconazole, but doesn't talk about

non-systemics.

- Kate

On Monday, October 10, 2005, at 12:05 AM, Kate wrote:

> I dunno why, I just assumed that yeast resistance would turn out to be

> a problem. 's Law, you know! Gee, that would be nice if it's not

> a problem, 'cause if one is taking long-term abx, one can't just treat

> it and beat it.

>

> - Kate