apoptosis, bacteria, phagocytes

[Guest guest]

I think it may contain some logical lapses (didnt actually nail em

down), but this paper has loads of info on pro-apoptosis by bacteria.

This strengthens the hypothesis that the reason NFkappaB signalling

has evolved to be antiapoptotic is that its impossible to keep our

apoptosis signalling machinery completely secure from direct

activation by proteins crafted by phagocytosis-avoiding extracellular

pathogens.

SOmething new: its notable that epithelial cells are also of

importance here. Causing apoptosis of nearby phagocytes allows

pathogens to avert phagocytosis, but causing apoptosis of nearby

epithelial cells could be equally crucial, by interrupting the

phsyical epithelial barrier, facilitating invasion of the tissue

beyond.

===================================================

Microbes Infect. 2003 Oct;5(12):1149-58. Related Articles, Links

Fascination with bacteria-triggered cell death: the significance of

Fas-mediated apoptosis during bacterial infection in vivo.

Menaker RJ, NL.

Research Institute, Rm. 8409, Hospital for Sick Children, 555

University Avenue, Toronto, Ont., Canada M5G 1X8.

Increasing evidence indicates that bacterial pathogens have developed

mechanisms to modulate the apoptotic signaling cascade of host cells

and thereby cause disease. The Fas death receptor pathway is one of

the most extensively investigated apoptotic signaling pathways. In

this review we discuss the role of Fas signaling during the interplay

between bacterial pathogens and the host in vivo.

Publication Types:

Review

Review, Tutorial

PMID: 14554257 [PubMed - indexed for MEDLINE]