Targeting of Endothelial Activation in Cerebral Malaria

[Guest guest]

Anybody know what LMP-420 is?

Nelly

http://medicine.plosjournals.org/perlserv/?request=get-document & doi=10.1371/journal.pmed.0020315

Targeting of Endothelial Activation in Cerebral Malaria

DOI: 10.1371/journal.pmed.0020315

Published: August 23, 2005

"(...)The results provide evidence for a dual inhibitory effect of LMP-420 on both TNF and LT in an in vitro model of cerebral malaria pathogenesis, when added either before or simultaneously with both cytokines, they said. LMP-420 also abolished the cytoadherence of ICAM-1-specific P. falciparum–parasitized red blood cells on these endothelial cells. Identical but weaker effects were observed when LMP-420 was added with LT. LMP-420 also caused a dramatic reduction of HBEC-5i vesiculation induced by TNF or LT stimulation.(...)"