Possible new compound for treatment of cerebral malaria

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Public release date: 22-Aug-2005

Contact: Ocampopress@...415-624-1224Public Library of Science

Possible new compound for treatment of cerebral malaria

In a paper published online in PLoS Medicine researchers from Marseille describe the effects of a new compound that may be a future treatment for patients with cerebral malaria. The compound LMP-420 inhibits two of the molecules produced in the brain when affected by cerebral malaria. Cerebral malaria is a complication that can occur in malaria caused by the parasite Plasmodium falciparum. In cerebral malaria, the parasites infect the red blood cells that accumulate within the very small capillaries that flow through the tissues of the brain. Even when treated, cerebral malaria has a fatality rate of 15% or more. Using an in vitro model of cerebral malaria, the researchers, led by Grau, found that LMP-420 potently reduced the activation of endothelial cells (cells that line the small blood vessels), how well malaria-infected red blood cells stuck to these endothelial cells, and the release of micro particles from the same cells¡Xthree major features of cerebral malaria. The authors caution that the experimental in vitro results do not necessarily predict potential efficacy in either animal models or humans, especially since in their model the LMP-420 had to be given before the disease process was established. Nevertheless, this avenue of research is a promising one to explore further.

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Citation: Wassmer SC, Cianciolo GJ, Combes V, Grau GE (2005) Inhibition of endothelial activation: A new way to treat cerebral malaria? PLoS Med 2(9): e245. CONTACT:Professor s Grau,CNRS UMR 602027, bd. MoulinMarseille, France F-13385+33-(0)491-32-46-48+33-(0)491-38-77-72 (fax)georges.grau@...

[Guest guest]

Nelly, Can you tell from this study, or do you already know, how

cerebral malaria actually causes death?

penny

> Public release date: 22-Aug-2005

>

> Contact: Ocampo

> press@p...

> 415-624-1224

> Public Library of Science

>

> Possible new compound for treatment of cerebral malaria

>

>

> In a paper published online in PLoS Medicine researchers from

Marseille describe the effects of a new compound that may be a

future treatment for patients with cerebral malaria. The compound

LMP-420 inhibits two of the molecules produced in the brain when

affected by cerebral malaria.

>

> Cerebral malaria is a complication that can occur in malaria

caused by the parasite Plasmodium falciparum. In cerebral malaria,

the parasites infect the red blood cells that accumulate within the

very small capillaries that flow through the tissues of the brain.

Even when treated, cerebral malaria has a fatality rate of 15% or

more.

>

> Using an in vitro model of cerebral malaria, the researchers, led

by Grau, found that LMP-420 potently reduced the activation

of endothelial cells (cells that line the small blood vessels), how

well malaria-infected red blood cells stuck to these endothelial

cells, and the release of micro particles from the same cells¡Xthree

major features of cerebral malaria.

>

> The authors caution that the experimental in vitro results do not

necessarily predict potential efficacy in either animal models or

humans, especially since in their model the LMP-420 had to be given

before the disease process was established. Nevertheless, this

avenue of research is a promising one to explore further.

>

>

> ###

> Citation: Wassmer SC, Cianciolo GJ, Combes V, Grau GE (2005)

Inhibition of endothelial activation: A new way to treat cerebral

malaria? PLoS Med 2(9): e245.

>

> CONTACT:

> Professor s Grau,

> CNRS UMR 6020

> 27, bd. Moulin

> Marseille, France F-13385

> +33-(0)491-32-46-48

> +33-(0)491-38-77-72 (fax)

> georges.grau@m...