Re: Ampligen & Tamiflu/now Glycyrrhizin

[Guest guest]

Glycyrrhizin- I had to look up the spelling too.

SO apparently the USA has nothing to say on this.

The Germans have always been way ahead on derivatives of

natural products.

Barb

J Med Chem. 2005 Feb 24;48(4):1256-9

Antiviral activity of glycyrrhizic acid derivatives against SARS-

coronavirus.

Hoever G, Baltina L, is M, Kondratenko R, Baltina L, Tolstikov

GA, Doerr HW, Cinatl J Jr.

Institute of Medical Virology, Johann Wolfgang Goethe University

furt, -Ehrlich-Strasse 40, 60596 furt, Germany.

Glycyrrhizin (GL) was shown to inhibit SARS-coronavirus (SARS-CoV)

replication in vitro. Here the anti-SARS-CoV activity of 15 GL

derivatives was tested. The introduction of 2-acetamido-beta-d-

glucopyranosylamine into the glycoside chain of GL resulted in 10-

fold increased anti-SARS-CoV activity compared to GL. Amides of GL

and conjugates of GL with two amino acid residues and a free 30-COOH

function presented up to 70-fold increased activity against SARS-CoV

but also increased cytotoxicity resulting in decreased selectivity

index.

PMID: 15715493 [PubMed - indexed for MEDLI

> > >

> > > Spokane, Washington

> > >

> > > " A local laboratory is teaming up with a bio-pharmaceutical

> company

> > to

> > > create a drug that could boost a person's immune system against

> the

> > > avian flu.

> > >

> > > " Hollister-Stier laboratories and the partner company are

> currently

> > in

> > > the early stages of drug production. Hollister-Stier would

> > manufacture

> > > the drug, Ampligen, pending FDA approval.

> > >

> > > " Ampligen is originally designed to relieve symptoms of chronic

> > fatigue

> > > syndrome, but recent research indicates pairing it with Tamiflu

> > makes a

> > > more effective defense against avian flu. Tamiflu is the only

> known

> > > anti-virul drug proven to stop avian flu. "

> > >

> > > http://www.kxly.com/common/getStory.asp?id=45436

> > >

> > > Sue ,

> > > Upstate New York

> > >

> >

>