Re: anti-serotonin and pro-dopamine combo

[Guest guest]

How about tianeptine and a dopamine agonist? I believe tianeptine

increases dopamine activity in a round about way due to the

acceleration of serotonin reuptake. The opposite of what an SSRI

does.

I have no idea if this is a safe combo, and haven't heard of anyone

trying this.

Luther

>

> like for ex. serotonin antagonist with dopamine agonist? , has

anyone

> tried these combination? Anti-serotonin like antihitamine

> cyproheptadine, I didnt know but remeron is serotonin 5-HT2 and 5-

HT3

> antagonist.(http://www.newshe.com/articles/SSRIsLBand2.shtml). Ive

been

> reading around the web that serotonin antagonist can possibly help

> while on SSRI but I wonder it would help in our case. If raising

> serotonin supresses dopamine will it do the same thing vice versa?

well

> just a thought.

>

[Guest guest]

Funny you should say that, Luther. I just started tianeptine yesterday. Just cycled off one month of dostinex and will cycle on and off dostinex (or maybe requip) while on tianeptine. If I tolerate the tianeptine OK, I will stay on it for about 6 months. I will also keep my T up around 850-900 ng/dl.

I can't think of any obvious reason why this would be hazardous, but can't specifically recommend it, and anybody thinking of doing same should go through their doctor (and that goes for anything discussed on this board). My mood is up today and I'm starting to feel some drive and motivation coming back, but no effect on libido yet. But we'll see. Maybe I'll have my first manic episode, LOL.

I'm convinced this is a gene expresion problem and it must be reversible. There's nothing wrong with our hardware, it's purely a software problem.

Pray for me guys...

Vornan> >> > like for ex. serotonin antagonist with dopamine agonist? , has > anyone > > tried these combination? Anti-serotonin like antihitamine > > cyproheptadine, I didnt know but remeron is serotonin 5-HT2 and 5-> HT3 > > antagonist.(http://www.newshe.com/articles/SSRIsLBand2.shtml). Ive > been > > reading around the web that serotonin antagonist can possibly help > > while on SSRI but I wonder it would help in our case. If raising > > serotonin supresses dopamine will it do the same thing vice versa? > well > > just a thought.> >>

[Guest guest]

Sounds like a solid plan, I'll certainly be praying for you.

Did you or anyone else ever try Trivastal? It's probably pretty

similar to requip/mirapex, but I wonder if it would be any more pro-

sexual than those two. For all of you outside of the U.S. who can

more easily get the servier drugs, I think I would give tianeptine

and trivastal a shot. Too bad amineptine is over, I think with

tianeptine it would make a very intriguing combo, both sexually and

as antidepressants.

> > >

> > > like for ex. serotonin antagonist with dopamine agonist? , has

> > anyone

> > > tried these combination? Anti-serotonin like antihitamine

> > > cyproheptadine, I didnt know but remeron is serotonin 5-HT2 and

5-

> > HT3

> > > antagonist.(http://www.newshe.com/articles/SSRIsLBand2.shtml).

Ive

> > been

> > > reading around the web that serotonin antagonist can possibly

help

> > > while on SSRI but I wonder it would help in our case. If raising

> > > serotonin supresses dopamine will it do the same thing vice

versa?

> > well

> > > just a thought.

> > >

> >

>

[Guest guest]

Vornan, I really hope you finally feel a libido recovery. It's a brave

thing to try tianeptine with a dopamine agonist. I'll be right behind

you following your lead if something positive emerges.

You are in my prayers every night...all of you guys are.

Biker

>

>

> Funny you should say that, Luther. I just started tianeptine

yesterday.

>

> Pray for me guys...

>

> Vornan

[Guest guest]

I haven't tried trivastal, but it does sound interesting. It seems

like, with the exception of wellbutrin, there has been a campaign to

keep most pro-sexual drugs off the market.

> > > >

> > > > like for ex. serotonin antagonist with dopamine agonist? , has

> > > anyone

> > > > tried these combination? Anti-serotonin like antihitamine

> > > > cyproheptadine, I didnt know but remeron is serotonin 5-HT2

and

> 5-

> > > HT3

> > > > antagonist.

(http://www.newshe.com/articles/SSRIsLBand2.shtml).

> Ive

> > > been

> > > > reading around the web that serotonin antagonist can possibly

> help

> > > > while on SSRI but I wonder it would help in our case. If

raising

> > > > serotonin supresses dopamine will it do the same thing vice

> versa?

> > > well

> > > > just a thought.

> > > >

> > >

> >

>

[Guest guest]

Thanks, Biker. How are things going on the abilify? Any changes?

> >

> >

> > Funny you should say that, Luther. I just started tianeptine

> yesterday.

> >

> > Pray for me guys...

> >

> > Vornan

>

[Guest guest]

For me, Dostinex was very sedating whereas Tianeptine was more

stimulating, similar to WB. So maybe it will be a tolerable combo.

It's good to see your mood and drive have improved. I figure my

libido decreased gradually over a period of 3 years, so maybe once

the right treatment is found, my libido will gradually kick back in

over a period of time.

Good luck, we're all pulling for you

Luther

> > >

> > > like for ex. serotonin antagonist with dopamine agonist? , has

> > anyone

> > > tried these combination? Anti-serotonin like antihitamine

> > > cyproheptadine, I didnt know but remeron is serotonin 5-HT2

and 5-

> > HT3

> > > antagonist.(http://www.newshe.com/articles/SSRIsLBand2.shtml).

Ive

> > been

> > > reading around the web that serotonin antagonist can possibly

help

> > > while on SSRI but I wonder it would help in our case. If

raising

> > > serotonin supresses dopamine will it do the same thing vice

versa?

> > well

> > > just a thought.

> > >

> >

>

[Guest guest]

how was the experience for you with tianeptine ?

> > > >

> > > > like for ex. serotonin antagonist with dopamine agonist? ,

has

> > > anyone

> > > > tried these combination? Anti-serotonin like antihitamine

> > > > cyproheptadine, I didnt know but remeron is serotonin 5-HT2

> and 5-

> > > HT3

> > > > antagonist.

(http://www.newshe.com/articles/SSRIsLBand2.shtml).

> Ive

> > > been

> > > > reading around the web that serotonin antagonist can

possibly

> help

> > > > while on SSRI but I wonder it would help in our case. If

> raising

> > > > serotonin supresses dopamine will it do the same thing vice

> versa?

> > > well

> > > > just a thought.

> > > >

> > >

> >

>

[Guest guest]

I only tried it for a week or so. Generally made me very irritable.

I think one of the mistakes I've made is I tried other drugs too

soon after stopping Celexa. I think it's important to give the brain

a rest for a few months to see if you can recover naturally. I've

been off all drugs for about 10 months or so. Currently I'm drinking

lots of green tea, and taking a few supplements to try to clean my

body out some more.

At some point I will get back on a drug regimen, and give it another

shot.

Luther

> > > > >

> > > > > like for ex. serotonin antagonist with dopamine agonist? ,

> has

> > > > anyone

> > > > > tried these combination? Anti-serotonin like antihitamine

> > > > > cyproheptadine, I didnt know but remeron is serotonin 5-

HT2

> > and 5-

> > > > HT3

> > > > > antagonist.

> (http://www.newshe.com/articles/SSRIsLBand2.shtml).

> > Ive

> > > > been

> > > > > reading around the web that serotonin antagonist can

> possibly

> > help

> > > > > while on SSRI but I wonder it would help in our case. If

> > raising

> > > > > serotonin supresses dopamine will it do the same thing

vice

> > versa?

> > > > well

> > > > > just a thought.

> > > > >

> > > >

> > >

> >

>

[Guest guest]

Trivastal is supposedly like a better mirapex (less side-effects, more

effective). It also have an alpha2 antagonist property to it, which

would give a norepinephrine boost. It's something I might try in the

future if cabergoline doesn't pan out.

Cyproheptadine (periacitin) looks interesting too, but I wish it

didn't have anti-histamine properties. I looked, and the only pure

serotonin antagonist is quite pricey, and seems to only hit 5ht3.

>

> I haven't tried trivastal, but it does sound interesting. It seems

> like, with the exception of wellbutrin, there has been a campaign to

> keep most pro-sexual drugs off the market.

>

[Guest guest]

I've had some problems with Abilify. For the third night in a row I

woke up at 3 am. and could no longer sleep. I can't seem to

concentrate properly at work, it's like I was under a huge amount of

stress all the time.

Abilify has not helped me like I hoped it would. The only positive

thing about it was the fact that in the beginning it gave me energy. I

felt a need to do something meaningful all the time.

But now I just don't seem to tolerate the side-effets.

Biker

>

> Thanks, Biker. How are things going on the abilify? Any changes?

[Guest guest]

This looks intriguing to me especially now that selegiline is a

transdermal patch. 6 mg patch plus standard dose of tianeptine? Seems

like its worth shot, at the very least probably a very nice

antidepressant combination.

http://www.dr-bob.org/babble/20040412/msgs/336766.html

[Guest guest]

I wouldn't recommend it. The 6mg patch is the equivalent to 20mg oral

selegiline, which is very potent. So I would try that for a while

before deciding whether to add something else to the mix. The patch

raises serotonin by the way in addition to dopamine and norepinephrine.

Many of the folks at Dr. Bob are on all kinds of crazy combos. I know

of a couple that are on an MAOI along with an SSRI...a definite no no.

Luther

>

> This looks intriguing to me especially now that selegiline is a

> transdermal patch. 6 mg patch plus standard dose of tianeptine?

Seems

> like its worth shot, at the very least probably a very nice

> antidepressant combination.

>

> http://www.dr-bob.org/babble/20040412/msgs/336766.html

>