S. aureus resistance to CAMP

[Guest guest]

S. aureus kicks ass at resisting CAMP. Deletion mutants clarify how

this resistance takes place - something I'm curous about for many

reasons.

Not all CAMP have been tested against all relevant S. aureus deletion

mutants. However, data exist on the following CAMP resistance

mechanisms in S. aureus. Note that the strength/weakness of the effects

may not hold for other CAMP and other situations which have not yet

been experimented with.

- placement of positive charges in the cell wall (weak)

- placement of positive charges in the membrane (strong)

- efflux of CAMP (weak; stronger in Neisseria)

Some of these findings have been corroborated using a model close to

nature - the deletion mutants are attenuated in experimental mouse

infection.