Guest guest Posted September 2, 2005 Report Share Posted September 2, 2005 Nelly I've spent some time looking for work showing non-helical Bb forms to be resistant, but havent been able to locate it. Theres that one by (I think) Aberer showing that more cysts etc formed in vitro in response to ceftriaxone (as opposed to non-B- lactam drugs), but that experiment was only 2 days long. I dont think it was made clear whether or not the ongoing presence of ceftriaxone would have prevented those variant forms from multiplying, or whether any forms would be able to multiply in the presence of tetracyclines, etc. The Jemsek Clinic treatment guidelines are referenced, yet they do not reference their statement that the non-helical forms have broad intrinsic resistance. Klempner famously showed that the presence of host cells protected Bb from eradication by high-dose ceftriaxone in vitro. But the mechanism for that was not investigated, and other workers found that protein- synth-inhibiting drugs did eradicate Bb from some sort of host cell culture. I looked for refs on this idea in some of the Brorson papers but cant recall whether I finished. Anyways I didnt find anything so far. So basically I havent seen anything showing that transformation into nonhelical forms averts bacteriostasis, ie allows ongoing reproduction in the presence of abx. If you or anyone can tip me off about any such experiment I'd head to the library extremely immediately. I havent got around to significant study on the sequestered anatomical sites problem yet, but hope to someday. > , > > Bb Cysts, blebs, granules? The Brorsons' studies etc Plenty to show that spiros do have mechanisms to ensure survival under " adverse circumstances " ie in the presence of most abx in-vitro. They can then be " reborn " from their mutated forms. > > In-vivo they also " flagelate " their way to sequestered sites very quickly and from there they can re-circulate and repopulate whenever they choose to. > > But of course that's only hearsay, since me, myself, personally have not got my own equipment in my backroom where I can play microbiologist and then scream at people that what " I don't see(or don't know enough about!) can't " possably " (sic) make you sick " . > > Nelly > > Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.