Re: effective doses in rodents versus humans

[Guest guest]

The problem is that there is no consistent ratio one can use - the

differences in rodent and human metabolism are not consistent from

one chemical to another.

You can get a little closer by looking at serum concentrations, if

the authors of the study are kind enough to provide them. Sometimes

a study will even tell you what dose (in mg/kg) is required to

achieve the same serum concentration in humans - but the validity of

this number will be only as solid as the assumptions underlying it.

S.

> ,

>

> Yes, I remarked on this when I was trying to work out dosages for

something or other and I was told that rodents did require higher

doses per weight. Too lazy to check it out but that was defintely

the answer I got

>

> Look at the full-text version of " the hamster study " that Jill and

I are closely looking at at the moment re Babesia treatment and tell

me what you think of the doses used, they seem HUGE (for not very

good results, in fact, eradication of babesias being measured by

surpassaging into healthy hamsters)

>

> http://aac.asm.org/cgi/reprint/41/1/91.pdf

>

> Nelly

> [infections] assorted

>

>

> This one would seem to support strongly the conclusion that the

> distribution/form/mechanics of even *acute* Bb infections are

very

> different in humans than in gerbils.

>

> THat would obviously be of high importance.