Re: MDR inhibitors applied in mice

[Guest guest]

, the second of those abstracts points to something hopeful, the

success in experiments at using compounds that inhibit efflux pumps

and increase the effectiveness of antibiotics that bugs use efflux

pumps to spit back out.

Any follow up on that, indicating that there are available substances

that perform just this function and are safe for human consumption

would of course be very welcome.

Cheers,

> Heres are 2 interesting meeting abstracts, basically pure data, from

> ICAAC, the Am Soc Microb conference on therapy.

>

> http://www.asm.org/memonly/abstracts/AbstractView.asp?AbstractID=415

>

> http://www.asm.org/memonly/abstracts/AbstractView.asp?

AbstractID=69690

[Guest guest]

The spectrum of most known MDR pump inhibitors (not many have been

examined) appears to be moderate. That is, it seems alot of them

inhibit multiple MDR pumps, but not all.

Alot of organisms have multiple MDR pumps, each with a very broad

but unique spectrum of substrates; therefore a potential problem is

one MDR efficiently extruding an inhibitor you deployed to clog

another pump. But experiment clearly shows that this complication is

not always fatal to the goal of MDR inhibition.

I am not seeing much yet on mammal toxicity of any of these

compounds being assayed.

Research/development in this area does not seem to be gaining much

momentum, tho it is getting significant scholarly attention. There

appears to be more than one plant species and even some antibiotic-

producing microorganisms employing the antimicrobial/antiMDR combo

strategy to protect themselves from bacteria, so nature may be a

good place to look for antiMDR compounds. Good thing we humans are

making room for cheap beef etc by casually shouldering various

biological species into the void. Unfortunately the next Penicillium

notatum could be restricted to a 10-square-mile range as many

rainforest organisms are/were. Whoops, hope that wasnt one of the

really important ones.

There were some firms like Microcide working on this... I think

Microcide has been re-named/re-born which is not necessarily a very

good sign... I dont think they have found much.

The chances of efflux being pivotal to the refractoriness of our

infections of interest is still mostly a matter of pure

logic/theory. I did find out from Tasha at eurolyme that Bb may have

a LPS functional analog, which is a boon to this area of

speculation, especially as the substance appears to be immunogenic,

thus providing motivation for its downregulation.

They could use some stronger efflux pumps right now in New Orleans,

much of which is below sea level. Looks like theres a hefty chance

the entire city will flood with extreme destruction.

> > Heres are 2 interesting meeting abstracts, basically pure data,

from

> > ICAAC, the Am Soc Microb conference on therapy.

> >

> > http://www.asm.org/memonly/abstracts/AbstractView.asp?

AbstractID=415

> >

> > http://www.asm.org/memonly/abstracts/AbstractView.asp?

> AbstractID=69690