Guest guest Posted September 4, 2005 Report Share Posted September 4, 2005 Thanks , I suspect that if some parmaceutical company had found a way to patent the active component of garlic, allicin, we'd be hearing a lot more about its merits. It most probably would also have antibacterial, antiviral properties as well, given the fact that saturating yourself with garlic really knocks down colds. In fact garlic if eaten raw and in large enough quantities seems to get into the bloodstream fast, and as far as I know the allicin is active in the blood, so for less urgent situations oral garlic might do the trick. We certainly eat loads but we tend to lapse and not be fanatical about eating it raw. I am sure it helps if you can keep up a good regular two or three time daily dosage and it has to be RAW. I wonder if Rich VanK could comment on the glutathione aspect: "It has been suggested that the reason human cells are not poisoned by allicin derivatives is that they contain glutathione, a sulfur-containing amino acid that combines with the allicin derivative, thus preventing cell damage." Does IV Allitridium + IV glutathione seem like a good combo to prevent cell damage? Nelly [infections] IV Garlic, Anyone? Mycoses. 2005 Mar;48(2):95-100. An overview of the antifungal properties of allicin and its breakdown products--the possibility of a safe and effective antifungal prophylactic. SR.Mycology Unit, Women's and Children's Hospital, North Adelaide, SA, Australia. sdavis@...Reports about the safe and successful intravenous (i.v.) use of garlic derivatives in China against invasive fungal infections have been made, but little has been done to seriously investigate the in vivo use of these derivatives in the West. Laboratories have demonstrated impressive in vitro MICs using allitridium, one of these derivatives, against a range of medically important fungi. In addition, it has been demonstrated that allitridium shows in vitro synergy with amphotericin B, one of the main i.v. antifungal agents. Some of the breakdown products of allicin, the main parent antifungal compound in garlic, have been investigated for their general antimicrobial, anticancer and anticholesterol properties, and it appears that there is a common mode of action that underlies these activities. It appears that these small molecules have the ability to cross cell membranes and combine with sulfur-containing molecular groups in amino acids and proteins, thus interfering with cell metabolism. It has been suggested that the reason human cells are not poisoned by allicin derivatives is that they contain glutathione, a sulfur-containing amino acid that combines with the allicin derivative, thus preventing cell damage. In addition to their biochemical mechanism, these derivatives appear to stimulate cellular immunity, an important ability lacking in conventional antifungal chemotherapy. These derivatives appear to be safe, cheap, wide-spectrum and immunostimulatory, as well as possibly synergistic with conventional antifungal therapy, making them ideal candidates for investigation into their use as prophylactic antifungal agents.Publication Types: Review Review, Tutorial PMID: 15743425 [PubMed - indexed for MEDLINE] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 4, 2005 Report Share Posted September 4, 2005 Thanks for that , It maybe policy to combine or rotate garlic with other oils..here's some extracts & the link to more on the subject http://tinyurl.com/c9tsc Anticancer Res. 2002 Nov-Dec;22(6C):4179-81. Related Articles, Links Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen.Mahady GB, Pendland SL, Yun G, Lu ZZ.Department of Pharmacy Practice, College of Pharmacy, WHO Collaborating Centre for Traditional Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. mahady@...BACKGROUND: Curcumin, a polyphenolic chemical constituent derived from turmeric (Curcuma longa), has been shown to prevent gastric and colon cancers in rodents. Many mechanisms have been proposed for the chemopreventative effects, although the effect of curcumin on the growth of Helicobacter pylori has not been reported. H. pylori is a Group 1 carcinogen and is associated with the development of gastric and colon cancer. MATERIALS AND METHODS: A methanol extract of the dried powdered turmeric rhizome and curcumin were tested against 19 strains of H. pylori, including 5 cagA+ strains. RESULTS: Both the methanol extract and curcumin inhibited the growth of all strains of H. pylori in vitro with a minimum inhibitory concentration range of 6.25-50 micrograms/ml. CONCLUSION: These data demonstrate that curcumin inhibits the growth of H. pylori cagA+ strains in vitro, and this may be one of the mechanisms by which curcumin exerts its chemopreventative effects.PMID: 12553052 [PubMed - indexed for MEDLINE] Nat Prod. 1998 Apr;61(4):542-5. Related Articles, Links Novel bioactivities of Curcuma longa constituents.Roth GN, Chandra A, Nair MG.Department of Horticulture, Michigan State University, East Lansing 48823, USA.Bioassay-directed fractionation of ethyl acetate extract from Curcuma longa Linn. rhizomes yielded three curcuminoids, which displayed topoisomerase I and II enzyme inhibition activity. Curcumin III (3) was the most active curcuminoid, inhibiting topoisomerase at 25 micrograms mL-1. Curcumin I (1) and curcumin II (2) inhibited the topoisomerases at 50 micrograms mL-1. Fractionation of the volatile oil from the rhizomes afforded ar-turmerone (4), which displayed mosquitocidal activity with an LD100 of 50 micrograms mL-1 on Aedes aegyptii larvae. Bioassay-directed fractionation of hexane extract from the turmeric leaves yielded labda-8(17),12-diene-15,16 dial (5) with antifungal activity against Candida albicans at 1 micrograms mL-1 and inhibited the growth of Candida kruseii and Candida parapsilosis at 25 micrograms mL-1. In addition, 5 displayed 100% mosquitocidal activity on A. aegyptii larvae at 10 micrograms mL-1.PMID: 9584408 [PubMed - indexed for MEDLINE] Planta Med. 2004 Jun;70(6):572-5. Related Articles, Links Chemical composition and antifungal activity of the essential oil of Thymbra capitata.Salgueiro LR, Pinto E, Goncalves MJ, Pina-Vaz C, Cavaleiro C, Rodrigues AG, Palmeira A, Tavares C, Costa-de-Oliveira S, ez-de-Oliveira J.Lab. de Farmacognosia, Faculdade de Farmacia/CEF, Universidade de Coimbra, P-3000 Coimbra, Portugal. ligia@...The composition and the antifungal activity of the essential oil of Thymbra capitata on Candida, Aspergillus and dermatophyte strains were studied. Twenty-two samples of the essential oils from the aerial parts of the plant were obtained by hydrodistillation and analysed by GC and GC-MS. All samples are of the carvacrol type, with a high content of carvacrol (60.0 - 65.8 %) and its biogenetic precursors, gamma-terpinene (8.2 - 9.5 %) and p-cymene (6.0 - 7.5 %). The minimal inhibitory concentration (MIC) and the minimal lethal concentration (MLC) were used to evaluate the antifungal activity against Candida (7 clinical isolates and 3 ATCC type strains), Aspergillus (5 clinical isolates, 2 CECT and 2 ATCC type strains) and 5 dermatophyte clinical strains. To clarify its mechanism of action on Candida strains, the inhibition of germ tube and a flow cytometry assay with propidium iodide (PI) were used. The oil exhibited antifungal activity for all the tested strains, particularly for dermatophytes, with MIC values ranging from 0.08 to 0.32 microL/mL. Regarding Candida, concentrations lower than the MIC values prevented germ tube formation. After a short incubation time the cells incorporated quickly PI, meaning that the fungicidal effect is mainly due to direct lesion of the membrane.PMID: 15229809 [PubMed - indexed for MEDLINE] -----Original Message-----From: infections [mailto:infections ]On Behalf Of SchaafsmaSent: 04 September 2005 11:59infections Subject: [infections] IV Garlic, Anyone?Mycoses. 2005 Mar;48(2):95-100. An overview of the antifungal properties of allicin and its breakdown products--the possibility of a safe and effective antifungal prophylactic. SR.Mycology Unit, Women's and Children's Hospital, North Adelaide, SA, Australia. sdavis@...Reports about the safe and successful intravenous (i.v.) use of garlic derivatives in China against invasive fungal infections have been made, but little has been done to seriously investigate the in vivo use of these derivatives in the West. Laboratories have demonstrated impressive in vitro MICs using allitridium, one of these derivatives, against a range of medically important fungi. In addition, it has been demonstrated that allitridium shows in vitro synergy with amphotericin B, one of the main i.v. antifungal agents. Some of the breakdown products of allicin, the main parent antifungal compound in garlic, have been investigated for their general antimicrobial, anticancer and anticholesterol properties, and it appears that there is a common mode of action that underlies these activities. It appears that these small molecules have the ability to cross cell membranes and combine with sulfur-containing molecular groups in amino acids and proteins, thus interfering with cell metabolism. It has been suggested that the reason human cells are not poisoned by allicin derivatives is that they contain glutathione, a sulfur-containing amino acid that combines with the allicin derivative, thus preventing cell damage. In addition to their biochemical mechanism, these derivatives appear to stimulate cellular immunity, an important ability lacking in conventional antifungal chemotherapy. These derivatives appear to be safe, cheap, wide-spectrum and immunostimulatory, as well as possibly synergistic with conventional antifungal therapy, making them ideal candidates for investigation into their use as prophylactic antifungal agents.Publication Types: Review Review, Tutorial PMID: 15743425 [PubMed - indexed for MEDLINE] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 4, 2005 Report Share Posted September 4, 2005 Yes. Have been looking into this for a while. How deeply I cannot say, but let's say, yes. However, in terms of IV allicin--you'd have to find a source you could absolutely trust in terms of sterility. You could kill yourself if the allicin was not sterile--or garlic oil--or whatever it is you want to use. Some AIDS patients did this back whenever, might've been the 80's or so. (didn't die). So if you want to come up with that source, more power to you . For instance this was used by the Chinese, but would YOU travel to China and trust someone there whose language you didn't even speak, to infuse you with garlic oil? And the Weizzman institute uses it intravenously in some experiments, so are we going to show up at their doors in Israel and ask that they infuse us? I think there may be better ways. I've familiarized myself with almost all the scientific literature but I did that a while back so I'm not sure I had this one. > Mycoses. 2005 Mar;48(2):95-100. > > > An overview of the antifungal properties of allicin and its > breakdown products--the possibility of a safe and effective > antifungal prophylactic. > > SR. > > Mycology Unit, Women's and Children's Hospital, North Adelaide, SA, > Australia. sdavis@e... > > Reports about the safe and successful intravenous (i.v.) use of > garlic derivatives in China against invasive fungal infections have > been made, but little has been done to seriously investigate the in > vivo use of these derivatives in the West. Laboratories have > demonstrated impressive in vitro MICs using allitridium, one of > these derivatives, against a range of medically important fungi. In > addition, it has been demonstrated that allitridium shows in vitro > synergy with amphotericin B, one of the main i.v. antifungal agents. > Some of the breakdown products of allicin, the main parent > antifungal compound in garlic, have been investigated for their > general antimicrobial, anticancer and anticholesterol properties, > and it appears that there is a common mode of action that underlies > these activities. It appears that these small molecules have the > ability to cross cell membranes and combine with sulfur-containing > molecular groups in amino acids and proteins, thus interfering with > cell metabolism. It has been suggested that the reason human cells > are not poisoned by allicin derivatives is that they contain > glutathione, a sulfur-containing amino acid that combines with the > allicin derivative, thus preventing cell damage. In addition to > their biochemical mechanism, these derivatives appear to stimulate > cellular immunity, an important ability lacking in conventional > antifungal chemotherapy. These derivatives appear to be safe, cheap, > wide-spectrum and immunostimulatory, as well as possibly synergistic > with conventional antifungal therapy, making them ideal candidates > for investigation into their use as prophylactic antifungal agents. > > Publication Types: > Review > Review, Tutorial > > PMID: 15743425 [PubMed - indexed for MEDLINE] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 4, 2005 Report Share Posted September 4, 2005 Nelly, you're right about that (how patent it?) Problem with oral garlic, which is fine and good, is you almost immediately break it down into its sulfur metabolites, some of which are somewhat antibacterial, and most CERTAINLY help with cholesterol and other stuff, so its very healthy for you, BUT is not going to tackle tickborne infections esp. since too much causes gastritis, but mostly because our digestive acids/enzymes break it down quickly. Yes, the glutathione is the reason why, supposedly, itsnot toxic to cells although allicin can be somewhat toxic to red blood cells in sufficient quantities. > Thanks , I suspect that if some parmaceutical company had found a way to patent the active component of garlic, allicin, we'd be hearing a lot more about its merits. > > It most probably would also have antibacterial, antiviral properties as well, given the fact that saturating yourself with garlic really knocks down colds. In fact garlic if eaten raw and in large enough quantities seems to get into the bloodstream fast, and as far as I know the allicin is active in the blood, so for less urgent situations oral garlic might do the trick. > > We certainly eat loads but we tend to lapse and not be fanatical about eating it raw. I am sure it helps if you can keep up a good regular two or three time daily dosage and it has to be RAW. > > I wonder if Rich VanK could comment on the glutathione aspect: > > " It has been suggested that the reason human cells > are not poisoned by allicin derivatives is that they contain > glutathione, a sulfur-containing amino acid that combines with the > allicin derivative, thus preventing cell damage. " > > Does IV Allitridium + IV glutathione seem like a good combo to prevent cell damage? > > Nelly > [infections] IV Garlic, Anyone? > > > Mycoses. 2005 Mar;48(2):95-100. > > > An overview of the antifungal properties of allicin and its > breakdown products--the possibility of a safe and effective > antifungal prophylactic. > > SR. > > Mycology Unit, Women's and Children's Hospital, North Adelaide, SA, > Australia. sdavis@e... > > Reports about the safe and successful intravenous (i.v.) use of > garlic derivatives in China against invasive fungal infections have > been made, but little has been done to seriously investigate the in > vivo use of these derivatives in the West. Laboratories have > demonstrated impressive in vitro MICs using allitridium, one of > these derivatives, against a range of medically important fungi. In > addition, it has been demonstrated that allitridium shows in vitro > synergy with amphotericin B, one of the main i.v. antifungal agents. > Some of the breakdown products of allicin, the main parent > antifungal compound in garlic, have been investigated for their > general antimicrobial, anticancer and anticholesterol properties, > and it appears that there is a common mode of action that underlies > these activities. It appears that these small molecules have the > ability to cross cell membranes and combine with sulfur- containing > molecular groups in amino acids and proteins, thus interfering with > cell metabolism. It has been suggested that the reason human cells > are not poisoned by allicin derivatives is that they contain > glutathione, a sulfur-containing amino acid that combines with the > allicin derivative, thus preventing cell damage. In addition to > their biochemical mechanism, these derivatives appear to stimulate > cellular immunity, an important ability lacking in conventional > antifungal chemotherapy. These derivatives appear to be safe, cheap, > wide-spectrum and immunostimulatory, as well as possibly synergistic > with conventional antifungal therapy, making them ideal candidates > for investigation into their use as prophylactic antifungal agents. > > Publication Types: > Review > Review, Tutorial > > PMID: 15743425 [PubMed - indexed for MEDLINE] > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 4, 2005 Report Share Posted September 4, 2005 Curcumin has estrogenic compounds...for me that would be bad and cause candida flareups! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 5, 2005 Report Share Posted September 5, 2005 I found tumeric has a couple of species of bacteria growing in it possably providing the zing (enzymes) to give it's unique flavour, so the end result could be a switching on of the immune system due to the bacterial threat, also possably the enzymes are creating a less environmentally pleasent place for pathogens to reside.I also find it acts similarly to bacterial stains it has very small molecules that normal bacterial stains use to get in and stain bacteria- also nullyfying there growth waves. > Thanks for that , It maybe policy to combine or rotate garlic with > other oils..here's some extracts & the link to more on the subject > > http://tinyurl.com/c9tsc > > Anticancer Res. 2002 Nov-Dec;22(6C):4179-81. > Related Articles, Links > > > > Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter > pylori, a group 1 carcinogen. > > Mahady GB, Pendland SL, Yun G, Lu ZZ. > > Department of Pharmacy Practice, College of Pharmacy, WHO Collaborating > Centre for Traditional Medicine, University of Illinois at Chicago, Chicago, > IL 60612, USA. mahady@u... > > BACKGROUND: Curcumin, a polyphenolic chemical constituent derived from > turmeric (Curcuma longa), has been shown to prevent gastric and colon > cancers in rodents. Many mechanisms have been proposed for the > chemopreventative effects, although the effect of curcumin on the growth of > Helicobacter pylori has not been reported. H. pylori is a Group 1 carcinogen > and is associated with the development of gastric and colon cancer. > MATERIALS AND METHODS: A methanol extract of the dried powdered turmeric > rhizome and curcumin were tested against 19 strains of H. pylori, including > 5 cagA+ strains. RESULTS: Both the methanol extract and curcumin inhibited > the growth of all strains of H. pylori in vitro with a minimum inhibitory > concentration range of 6.25-50 micrograms/ml. CONCLUSION: These data > demonstrate that curcumin inhibits the growth of H. pylori cagA+ strains in > vitro, and this may be one of the mechanisms by which curcumin exerts its > chemopreventative effects. > > PMID: 12553052 [PubMed - indexed for MEDLINE] > > > > > > Nat Prod. 1998 Apr;61(4):542-5. > Related Articles, Links > > > > Novel bioactivities of Curcuma longa constituents. > > Roth GN, Chandra A, Nair MG. > > Department of Horticulture, Michigan State University, East Lansing 48823, > USA. > > Bioassay-directed fractionation of ethyl acetate extract from Curcuma longa > Linn. rhizomes yielded three curcuminoids, which displayed topoisomerase I > and II enzyme inhibition activity. Curcumin III (3) was the most active > curcuminoid, inhibiting topoisomerase at 25 micrograms mL-1. Curcumin I (1) > and curcumin II (2) inhibited the topoisomerases at 50 micrograms mL-1. > Fractionation of the volatile oil from the rhizomes afforded ar- turmerone > (4), which displayed mosquitocidal activity with an LD100 of 50 micrograms > mL-1 on Aedes aegyptii larvae. Bioassay-directed fractionation of hexane > extract from the turmeric leaves yielded labda-8(17),12-diene- 15,16 dial (5) > with antifungal activity against Candida albicans at 1 micrograms mL-1 and > inhibited the growth of Candida kruseii and Candida parapsilosis at 25 > micrograms mL-1. In addition, 5 displayed 100% mosquitocidal activity on A. > aegyptii larvae at 10 micrograms mL-1. > > PMID: 9584408 [PubMed - indexed for MEDLINE] > > > > > > > > Planta Med. 2004 Jun;70(6):572-5. > Related Articles, Links > > > > Chemical composition and antifungal activity of the essential oil of Thymbra > capitata. > > Salgueiro LR, Pinto E, Goncalves MJ, Pina-Vaz C, Cavaleiro C, Rodrigues AG, > Palmeira A, Tavares C, Costa-de-Oliveira S, ez-de-Oliveira J. > > Lab. de Farmacognosia, Faculdade de Farmacia/CEF, Universidade de Coimbra, > P-3000 Coimbra, Portugal. ligia@f... > > The composition and the antifungal activity of the essential oil of Thymbra > capitata on Candida, Aspergillus and dermatophyte strains were studied. > Twenty-two samples of the essential oils from the aerial parts of the plant > were obtained by hydrodistillation and analysed by GC and GC-MS. All samples > are of the carvacrol type, with a high content of carvacrol (60.0 - 65.8 %) > and its biogenetic precursors, gamma-terpinene (8.2 - 9.5 %) and p- cymene > (6.0 - 7.5 %). The minimal inhibitory concentration (MIC) and the minimal > lethal concentration (MLC) were used to evaluate the antifungal activity > against Candida (7 clinical isolates and 3 ATCC type strains), Aspergillus > (5 clinical isolates, 2 CECT and 2 ATCC type strains) and 5 dermatophyte > clinical strains. To clarify its mechanism of action on Candida strains, the > inhibition of germ tube and a flow cytometry assay with propidium iodide > (PI) were used. The oil exhibited antifungal activity for all the tested > strains, particularly for dermatophytes, with MIC values ranging from 0.08 > to 0.32 microL/mL. Regarding Candida, concentrations lower than the MIC > values prevented germ tube formation. After a short incubation time the > cells incorporated quickly PI, meaning that the fungicidal effect is mainly > due to direct lesion of the membrane. > > PMID: 15229809 [PubMed - indexed for MEDLINE] > > > > [infections] IV Garlic, Anyone? > > > Mycoses. 2005 Mar;48(2):95-100. > > > An overview of the antifungal properties of allicin and its > breakdown products--the possibility of a safe and effective > antifungal prophylactic. > > SR. > > Mycology Unit, Women's and Children's Hospital, North Adelaide, SA, > Australia. sdavis@e... > > Reports about the safe and successful intravenous (i.v.) use of > garlic derivatives in China against invasive fungal infections have > been made, but little has been done to seriously investigate the in > vivo use of these derivatives in the West. Laboratories have > demonstrated impressive in vitro MICs using allitridium, one of > these derivatives, against a range of medically important fungi. In > addition, it has been demonstrated that allitridium shows in vitro > synergy with amphotericin B, one of the main i.v. antifungal agents. > Some of the breakdown products of allicin, the main parent > antifungal compound in garlic, have been investigated for their > general antimicrobial, anticancer and anticholesterol properties, > and it appears that there is a common mode of action that underlies > these activities. It appears that these small molecules have the > ability to cross cell membranes and combine with sulfur- containing > molecular groups in amino acids and proteins, thus interfering with > cell metabolism. It has been suggested that the reason human cells > are not poisoned by allicin derivatives is that they contain > glutathione, a sulfur-containing amino acid that combines with the > allicin derivative, thus preventing cell damage. In addition to > their biochemical mechanism, these derivatives appear to stimulate > cellular immunity, an important ability lacking in conventional > antifungal chemotherapy. These derivatives appear to be safe, cheap, > wide-spectrum and immunostimulatory, as well as possibly synergistic > with conventional antifungal therapy, making them ideal candidates > for investigation into their use as prophylactic antifungal agents. > > Publication Types: > Review > Review, Tutorial > > PMID: 15743425 [PubMed - indexed for MEDLINE] > > > > > > Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.