Re: Re: Cpn, Serology, Tini, etc

[Guest guest]

im skinny and my cholesterol is high!

On 21 Aug 2005, at 06:19, penny wrote:

> Interesting about the cholesterol/endotoxin relationship. My last

> lab reports are now showing much worse cholesterol levels. The new

> development being a bad hdl/ldl ratio since both are now high. The

> recommendation is to consider treatment. Perhaps my cholesterol has

> increased to deal with an increase in endotoxin production (caused

> by a higher rate of bacterial death?).

>

> I don't know. All I know is I feel much better. :-)

>

> penny

>

>

>

> > Penny-

> > Cpn serology is useful... depending. If you have

> > elevated IGM way out of proportion, or IGA indicating

> > an acute infection, or both IGA and IGM it is

> > significant. But general blood titers only show up in

> > an acute infection, or if you are sampling the tissue

> > infected (e.g. cerebrospinal fluid in to pick it up in

> > MS). Serology does not a diagnosis make, although it

> > may be one of the evidentiary sources for a diagnosis.

> > See the quote below for more.

> >

> > I have tried charcoal, and the Entreclenz-- truly the

> > only way to deliver the high dose of charcoal! But the

> > Vit C Flush works better for me. Currently I'm on doxy

> > + zith and tini pulses (500mg x 2) 5 days every three

> > weeks. I'm adding in amoxy slowly (a significant kick

> > from it).

> > What's improved since I've been on this (since Nov

> > 04)? Significantly less inflammation and pain, lower

> > cholesterol and better ratio (apparently you use

> > cholesterol to bind Cpn endotoxin see

> > http://www.jlr.org/cgi/content/full/44/12/2339?

> maxtoshow= & HITS=10 & hits=10 & RESULTFORMAT= & author1=Kitchens & andorexactf

> ulltext=and & searchid=1124594832631_596 & stored_search= & FIRSTINDEX=0 & re

> sourcetype=1 & journalcode=jlr),

> > CRP is normal (was elevated into high risk) less

> > fatigue, less back pain. I'd say a 40% improvement in

> > these symptoms. Brain fog has not yet changed.

> >

> > Kate-

> > What dose of Tini are you using? When I switched to it

> > my doc was clueless about dosage, so at

> > Wheldon's suggestion I've been taking 500mg twice a

> > day during the pulses. I'd be curious if I should go a

> > bit higher.

> >

> > The reason Flagyl is pulsed is that in Cpn the regular

> > abx which you take continuously prevent replication

> > and create a " stringent " response in the bacterium,

> > driving it into it's non-replicating intracellular

> > form where it can be killed by an anaerobic agent like

> > Flagyl. You pulse it, because Flagyl is often not well

> > tolerated and in longer courses can have problematic

> > side effects (like peripheral neuropathy). So shorter

> > courses on a regular basis is often better tolerated

> > and less likely to cause side effects. I've seen

> > Lyme's doc's do this also, usually longer pulses of

> > 7-10 days at the end of each month. But I don't think

> > the regular abx are understood to drive Lyme's into

> > cystic phase, or at least not in anything I've seen.

> >

> > From:

> > http://herkules.oulu.fi/isbn9514269853/html/x467.html

> > 2.2.8.2. Serology

> > So far, serology has been the most frequently used

> > method for diagnosing C. pneumoniae infections. The

> > best serological evidence of acute infection is a

> > four-fold rise in IgG or IgA antibody titer between

> > paired sera taken several weeks apart. A positive IgM

> > antibody titre is also considered a marker of a

> > current or recent infection. In primary infection, IgM

> > antibodies are produced about 3 weeks after the onset

> > of the illness, whereas IgG and IgA antibodies may not

> > appear until 6–8 weeks after onset. In reinfection, on

> > the other hand, IgM antibodies appear only at low

> > titers, if at all. IgG and IgA titers rise quickly,

> > within 1 or 2 weeks, and may reach very high levels.

> > IgM titre usually begins to fall within 2 months and

> > disappears within 4–6 months. IgA antibodies also have

> > a short half-life, whereas IgG antibodies persist in

> > the body and may be detectable for more than 3 years.

> > Especially older patients, who have probably had

> > multiple C. pneumoniae infections, may have

> > persistently high IgG titers. (Reviewed in Kuo et al.

> > 1995)

> > Serology is an inadequate indicator of chronic

> > infection (Saikku 1999). It does not indicate the

> > locality of the possible chronic process, and the high

> > frequency of C. pneumoniae antibodies in people makes

> > it difficult to prove an association with a specific

> > disease. In spite of these problems, continuously

> > elevated antibody titers have been considered a

> > reliable marker of chronic infection (reviewed by

> > Saikku 1999). Persistent production of IgA antibodies,

> > compared to long-lasting IgG antibodies, seems to be a

> > better marker in chronic infections (Saikku et al.

> > 1992, Laurila et al. 1997a, Laurila et al. 1997b).

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