Re: Scha- HCQ as an immune modulator

[Guest guest]

Interestlingly, I just read a paper where the cytokine profiles

in Malaria were mapped between people who had hepatic impairment and

those that didn't in Korea. Everything was equal between the 2

groups EXCEPT cytokine profiles.

SEE REFERENCE " Serum cytokine profiles in patients with p. Vivax

malaria: a comparisom between those that presented with and without

hepatic dysfunction " Ruyal Society of Tropical Medicine and Hygiene

(2003).

Repost of #4763 see below:

HCQ's been around - what 50 years or something- and they're just

finding out it's modulating mechanism... and for some it works like

a miracle , and for others Zip.

Benicar's been around for just a few years, and while we don't know

what all it's mechanism are - it's safe to say we do know that it's

doing more than just controlling bp.

Barb

> :

>

> Here are a few abstracts about HCQ as an immune modulator -

> selectively supressing pro inflammatory cytokines.

> And like all effective drugs- it can have side effects- I've added

> one abstract at the end re muscle weakness.

>

>

> SELECTIVE cytokine regulation by HCQ

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

> cmd=Retrieve & db=PubMed & list_uids=8336306 & dopt=Abstract

>

>

> HCQ as a microglia modulator

> http://www.immuno2004.org/onlineabstracts/2322.html

>

> HCQ side-effects (muscle weakness).

> http://www3.interscience.wiley.com/cgi-

bin/abstract/110433649/ABSTRACT

>

>

>

> wrote in part:

> Barb Peck's done a masterful job of documenting the value of HCQ in

> alkalizing the cell compartment to maximize both antibiotic and

> antifungal drug action against bugs, but it also has an immune mod

> effect which I don't entirely understand. i think it might be an

> interesting one to look at.

[Guest guest]

Thaks, Barb. I meant to thank you earlier for the previous posts,

the references were fascinating, particularly the microglia

modulation.

It seems like there's a pretty strong suppression of TNF-alpha in

body and brain both, which under many circumstances could be

desirable. I'm gonna look at this again later and see if I can find

anything more - if I come acros something that adds to what you've

shared here, I'll pass it on.

> > :

> >

> > Here are a few abstracts about HCQ as an immune modulator -

> > selectively supressing pro inflammatory cytokines.

> > And like all effective drugs- it can have side effects- I've

added

> > one abstract at the end re muscle weakness.

> >

> >

> > SELECTIVE cytokine regulation by HCQ

> > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

> > cmd=Retrieve & db=PubMed & list_uids=8336306 & dopt=Abstract

> >

> >

> > HCQ as a microglia modulator

> > http://www.immuno2004.org/onlineabstracts/2322.html

> >

> > HCQ side-effects (muscle weakness).

> > http://www3.interscience.wiley.com/cgi-

> bin/abstract/110433649/ABSTRACT

> >

> >

> >

> > wrote in part:

> > Barb Peck's done a masterful job of documenting the value of HCQ

in

> > alkalizing the cell compartment to maximize both antibiotic and

> > antifungal drug action against bugs, but it also has an immune

mod

> > effect which I don't entirely understand. i think it might be an

> > interesting one to look at.