Re: Inflammation ( was chlamydia, ReA - )

[Guest guest]

:

It's probably the interaction between the host and the bacteria.

I've been reading about the hosts adaptation to the constant presence

of a pathogen. It's suspected that immune complexes (the antibody

and the antigen bound together) stay bound so the anitbody is never

freed - and are responsiple for alot of the infammation - i.e. the

complex fuels the inflammation swtich.

In Lyme anyway, attempts to find a difference (in immune complex

formation or not) and tie it to tissue type has failed.

There are some interesting European papers on asymptomatic high

IgG Lyme titered forrestry workers. SO it's sort of relevant that

one can have a high IgG titer and feel fine. I assume it's because

the immune system is keeping the population in check.

I'll have to see if estimated bacterial load can correlate to high or

low IgG titer for Lyme.. it must be in those 'forrestry worker'

papers.. I bet the researched pulled enough blood from them to study

for years.

Barb

> > Chlamydia pneumonia is not sexually transmitted. You

> > probably know that but I just wanted to clarify that

> > we are talking about two different things. I am

> > guessing they make two different antibiodies.

> > Marie

>

> That same paper (see upthread) notes that Cpn as well as C.

> trachomatis has been associated with arthritis, by some of the same

> investigative techniques. It also explores the possibility of

> transmission of Cpn by other means than respiratory fluids, such as

> blood transfusion. I dont recall whether it addressed sex (I am

home

> now away from the full text).

>

> (Unrelatedly), the one thing I'm not satisfied with yet regarding

> this disease model is the establishment of a clear difference from

> healthy controls. It seems some control synovia are positive for

both

> of these chlamydial species by PCR, but clearly if the healthies

have

> 800x fewer organisms, that would explain why they are not ill. I

> havent found *quantitative* case v control data yet.

>

> If some healthies have loads similar to those of sickies, then that

> will be another mind-wrencher right along the lines of the rare

> LYMErix vaccine-induced illnesses. We know very little about

> asymptomatic infections (which seem to be present in all humans and

> mice, if not all mammals), or what may govern toleration of them.