Whipple bacillus perfectly abx-sensitive in culture

[Guest guest]

Didnt even know this lil piece of crap had been cultured; I think

thats rather recent.

Havent read this full text but it is definitely quite sensitive to

clinical concentrations of a number of drugs.

THerapy of the human infection is usually multi-year and I have some

vague info regarding a significant number of incomplete cures (tho no

hard data). Therefore this looks like another probable multi-drug

vitro/vivo sensitivity paradox. Collect em all.

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The active compounds in axenic medium were doxycycline, macrolide

compounds, penicillin G, streptomycin, rifampicin, chloramphenicol,

thiamphenicol, teicoplanin, vancomycin, amoxicillin, gentamicin,

aztreonam, levofloxacin and ceftriaxone, with MICs in the range 0.06-

1 mg/L. Cefalothin was less active, with MICs in the range 2-4 mg/L.

We found that co-trimoxazole was active with MICs in the range 0.5-1

mg/L, and sulfamethoxazole alone was active with MICs in the range

0.5-1 mg/L.

PMID: 15650004