Re: gestational lyme borreliosis - could be useful for docs

[Guest guest]

Where are the murine studies proving or disproving sexual

transmission, gestational transmission or transmission during

lactation. Pretty simple and inexpensive to design and conduct.

There must be a political line somewhere that can't crossed. Dr. Ray

in CT must have data in his patient records that confirms all

of the above.

Tom Brown

> Anyone having trouble with doctors who buy the waterfowl line on

> congenital lyme ( " unproven " ) should look at Alan

> Mac's " gestational lyme borreliosis, " 1989.

>

> I dont have time to comb it right now, so I dont know whether it is

> proof - but I can see it has lots of immunofluorescence pics from

> deceased fetuses and newborns. It certainly appears to be conclusive

> at least as a proof of principle.

[Guest guest]

Harvey & Salvato reference such animal data - I dont know whether its

observational (veterinary) and/or controlled. Whichever it is I would

guess it was probably not fostered by NIH.

Those authors also quote the CDC as stating (I think?) that human-to-

human xmission of lyme disease does not occur.

Stricker has a study on sex xmission which is very indirect - in

dually-infected couples of which only one person has tickbite hx,

there are statistically significant differences in NK-cell counts,

and also I think disease severity, between the bitten and the

unbitten. THis is not in pubmed cause its a presentation at some

kinda ID conference. I read the presentation abstract.

> > Anyone having trouble with doctors who buy the waterfowl line on

> > congenital lyme ( " unproven " ) should look at Alan

> > Mac's " gestational lyme borreliosis, " 1989.

> >

> > I dont have time to comb it right now, so I dont know whether it

is

> > proof - but I can see it has lots of immunofluorescence pics from

> > deceased fetuses and newborns. It certainly appears to be

conclusive

> > at least as a proof of principle.

[Guest guest]

Designing a robust human study to investigate so called sexual transmission or

any

person-to-person transmission is actually quite difficult. The major problem

with

any studies to date and all anecdotal evidence on this subject suffers the same

confound that would be difficult to deal with in any new study, namely that

these co-

located people are equally exposed to tick transmission.

> > Anyone having trouble with doctors who buy the waterfowl line on

> > congenital lyme ( " unproven " ) should look at Alan

> > Mac's " gestational lyme borreliosis, " 1989.

> >

> > I dont have time to comb it right now, so I dont know whether it is

> > proof - but I can see it has lots of immunofluorescence pics from

> > deceased fetuses and newborns. It certainly appears to be conclusive

> > at least as a proof of principle.

[Guest guest]

Well, except for babies. I'm pretty sure my son wasn't bitten; he

wasn't crawling around outside at all for the first 9 months of his

life, and that's when the symptoms began.

- Kate

On Wednesday, August 24, 2005, at 10:20 AM, duramater27 wrote:

> Designing a robust human study to investigate so called sexual

> transmission or any

> person-to-person transmission is actually quite difficult.  The major

> problem with

> any studies to date and all anecdotal evidence on this subject suffers

> the same

> confound that would be difficult to deal with in any new study, namely

> that these co-

> located people are equally exposed to tick transmission.

[Guest guest]

Actually, that would still be a difficult study. Presumably your son lives with

adults

and any one/thing else going in/out of home in tick-living area can bring ticks

in...

same way that adults get infected by dogs or other adults inadvertently bringing

ticks

into the home. That's the whole point...

>

> > Designing a robust human study to investigate so called sexual

> > transmission or any

> > person-to-person transmission is actually quite difficult.  The major

> > problem with

> > any studies to date and all anecdotal evidence on this subject suffers

> > the same

> > confound that would be difficult to deal with in any new study, namely

> > that these co-

> > located people are equally exposed to tick transmission.