Jill: 2 abstracts on fosmidomycin versus malaria, plus yr lnk led to triclosan

[Guest guest]

" jill1313 " <jenbooks13@h...> wrote:

> Thanx but I am confused...I talked of fosmidomycin...I didn't

> know about triclosan...

I read message #4630, replying to a post by you. In your post

was a clickable link to a paper of triclosan as an antimalarial

agent.

Perhaps you posted the wrong link to , by accident?

About fosmidomycin: two abstracts of fairly recent vintage below.

The first abstract, from last month, describes a derviative of

fosmidomycin that they say has improved antimalarial activity

(citing a mouse study).

The second abstract, from last November, cites some pretty

impressive clearance rates for fosmidomycin plus clindamycin in

pediatric patients in Gabon, Africa.

1: Arch Pharm (Weinheim). 2005 Jul;338(7):305-14.

Alkoxycarbonyloxyethyl ester prodrugs of FR900098 with improved in

vivo antimalarial activity.

Ortmann R, Wiesner J, Reichenberg A, Henschker D, Beck E, Jomaa H,

Schlitzer M.

Department fur Pharmazie, Ludwig-Maximilians-Universitat, Munchen,

Germany.

FR900098 represents a derivative of the new antimalarial drug

fosmidomycin with enhanced activity. The mechanism of action is the

inhibition of the 1-desoxy-D-xylulose 5-phosphate (DOXP)

reductoisomerase, an essential enzyme of the mevalonate independent

pathway of isoprenoid biosynthesis. Prodrugs with increased oral

activity in mice infected with the rodent malaria parasite

Plasmodium vinckei were obtained by masking the phosphonate moiety

of FR900098 as alkoxycarbonyloxyethyl esters.

PMID: 15996004 [PubMed - in process]

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2: J Infect Dis. 2004 Nov 1;190(9):1534-40. Epub 2004 Sep 21.

Related Articles, Links

Fosmidomycin-clindamycin for the treatment of Plasmodium falciparum

malaria.

Borrmann S, Issifou S, Esser G, Adegnika AA, Ramharter M, Matsiegui

PB, Oyakhirome S, Mawili-Mboumba DP, Missinou MA, Kun JF, Jomaa H,

Kremsner PG.

Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon,

Germany.

It has been demonstrated that fosmidomycin has good tolerability and

rapid onset of action, but late recrudescences preclude its use

alone; in vitro, clindamycin has been shown to act synergistically

with fosmidomycin against Plasmodium falciparum.

We conducted a study in pediatric outpatients with P. falciparum

malaria in Gabon to evaluate the efficacy and safety of an oral

combination of fosmidomycin-clindamycin of 30 mg/kg and 10 mg/kg of

body weight, respectively, every 12 h. Patients 7-14 years old were

recruited in cohorts of 10.

The first 10 patients were treated for 5 days. The duration of

treatment was then incrementally shortened in intervals of 1 day if

>85% of the patients in a cohort were cured by day 14. All dosing

regimens were well tolerated, and no serious adverse events

occurred. Asexual parasites and fever rapidly cleared in all

patients.

Cure ratios of 100% on day 14 were achieved with treatment durations

of 5 (10/10 patients), 4 (10/10 patients), 3 (10/10 patients), and 2

days (10/10 patients); 1 day of treatment led to a cure ratio of 50%

(5/10 patients). Fosmidomycin-clindamycin is safe and well

tolerated, and short-course regimens achieved high efficacy in

children with P. falciparum malaria. Fosmidomycin-clindamycin is a

promising novel treatment option for malaria.

Publication Types:

Clinical Trial

PMID: 15478056 [PubMed - indexed for MEDLINE]

> > > > > I hope you have time to read all this stuff on

plastids.

> > > > > Its way cool.

> > > > >

> > > > > http://www.ajtmh.org/cgi/content/full/68/3/334

> > > > >

> > > > > I'm pretty sure bab microti will have plastids.

> > > > > I'm going to email a couple babs experts and see what they

> > think.

> > > > > Don't see why this hasn't been tried in mep/zith failures.

> > > > >

> > > > > maybe you could use arthemos, and fosmidomycin. Maybe five

> > days

> > > of

> > > > > that would be okay, if I can't tolerate the larium-like

drug

> > in

> > > > > riamet. Or follow up with some fosmidoymycin. Who knows.

Got

> > to

> > > > think

> > > > > this out thoroughly. Its strange how SOME coinfected folk

> > cannot

> > > get

> > > > > rid of their babs.

[Guest guest]

I inadvertantly must've included that link as I never read up on

triclosan.

Yes , it IS impressive and what is so disheartening is they have

not been able to get funding.

I don't get it.

If you target the plastid, I have a feeling that could be very

effective.

There's some reason babesia recrudesces--not in Barb--but in many

lyme patients.

Maybe her tetracycline killed a gametocyte that babesia may have. Who

knows.

> > > > > > I hope you have time to read all this stuff on

> plastids.

> > > > > > Its way cool.

> > > > > >

> > > > > > http://www.ajtmh.org/cgi/content/full/68/3/334

> > > > > >

> > > > > > I'm pretty sure bab microti will have plastids.

> > > > > > I'm going to email a couple babs experts and see what

they

> > > think.

> > > > > > Don't see why this hasn't been tried in mep/zith failures.

> > > > > >

> > > > > > maybe you could use arthemos, and fosmidomycin. Maybe

five

> > > days

> > > > of

> > > > > > that would be okay, if I can't tolerate the larium-like

> drug

> > > in

> > > > > > riamet. Or follow up with some fosmidoymycin. Who knows.

> Got

> > > to

> > > > > think

> > > > > > this out thoroughly. Its strange how SOME coinfected folk

> > > cannot

> > > > get

> > > > > > rid of their babs.