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Dobyns PMG Research

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Hi All

I received an e-mail from Patti Mills yesterday regarding my interest in

having in the research. She was very nice about it but told me they

did not need samples from because she most likely does not share the

genetic changes present in other children with PMG that they will be

studying. has some features that are atypical of other PMG kids,

meaning her advanced growth and the size and shape of her head and the fact

that she is seizure free and other things.

Patti stated that " Regarding our future efforts to learn more about PMG, our

first step will be to look for genes and gene changes that are likely to be

responsible for the typical presentations of PMG. As we gain a better

understanding of these genes, we are likely to develop hypotheses about

variations in these genes or in related genes that might explain more varied

clinical presentations, such as 's. For this reason, we don't have

an immediate need for samples from . "

( - born 7/14/98 w/PMG)

Northern California

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