Re: : cytokine supression by pathogens

[Guest guest]

But if these data are correct (which is faaaaar from clear) one would

want to find out if the excess IL-10 signalling were preventing

clearance of the bug. And if so one would want to modulate the immune

system in roughly the opposite direction that benicar and HCQ do.

IL-10 stimulation does seem to play a big role in Mtb's preventing

its phagocyte home from committing apoptosis, at least according to

one paper. It doesnt look like Mtb actively stimulates IL-10 by

excreting a factor to interact with the host, rather its very lipids

seem to do the job. I dont think the host receptor thru which this

occurs has been identified.

> >

> > Interestlingly, I just read a paper where the cytokine profiles

> > in Malaria were mapped between people who had hepatic impairment

> and

> > those that didn't in Korea. Everything was equal between the 2

> > groups EXCEPT cytokine profiles.

> > SEE REFERENCE " Serum cytokine profiles in patients with p. Vivax

> > malaria: a comparisom between those that presented with and

without

> > hepatic dysfunction " Ruyal Society of Tropical Medicine and

Hygiene

> > (2003).

> >

> >

> > Repost of #4763 see below:

> >

> > HCQ's been around - what 50 years or something- and they're just

> > finding out it's modulating mechanism... and for some it works

> like

> > a miracle , and for others Zip.

> >

> > Benicar's been around for just a few years, and while we don't

> know

> > what all it's mechanism are - it's safe to say we do know that

it's

> > doing more than just controlling bp.

> >

> > Barb

> >

[Guest guest]

:

The interaction is more complicated than just listing the chemicals

that are pro and anti- inflammatory.

Take a look at this site, and the quote below

http://www.copewithcytokines.de/cope.cgi?007884

QUOTE

The net effect of an inflammatory response is determined by the

balance between pro-inflammatory and anti-inflammatory cytokines . It

should be noted that the common and clear-cut classification of

cytokines as either pro anti-inflammatory or pro-inflammatory may be

misleading. The type, duration, and also the extent of cellular

activities induced by one particular cytokine can be influenced

considerably by the nature of the target cells, the micro-environment

of a cell, depending, for example, on the growth and activation state

of the cells, the type of neighboring cells, cytokine concentrations,

the presence of other cytokines , and even on the temporal sequence

of several cytokines acting on the same cell. END QUOTE

> > >

> > > Interestlingly, I just read a paper where the cytokine profiles

> > > in Malaria were mapped between people who had hepatic

impairment

> > and

> > > those that didn't in Korea. Everything was equal between the 2

> > > groups EXCEPT cytokine profiles.

> > > SEE REFERENCE " Serum cytokine profiles in patients with p.

Vivax

> > > malaria: a comparisom between those that presented with and

> without

> > > hepatic dysfunction " Ruyal Society of Tropical Medicine and

> Hygiene

> > > (2003).

> > >

> > >

> > > Repost of #4763 see below:

> > >

> > > HCQ's been around - what 50 years or something- and they're just

> > > finding out it's modulating mechanism... and for some it works

> > like

> > > a miracle , and for others Zip.

> > >

> > > Benicar's been around for just a few years, and while we

don't

> > know

> > > what all it's mechanism are - it's safe to say we do know that

> it's

> > > doing more than just controlling bp.

> > >

> > > Barb

> > >